| Full name: death domain associated protein | Alias Symbol: DAP6 | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 1616 | HGNC ID: HGNC:2681 | Ensembl Gene: ENSG00000204209 | OMIM ID: 603186 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
DAXX involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04210 | Apoptosis | |
| hsa05014 | Amyotrophic lateral sclerosis (ALS) |
Expression of DAXX:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DAXX | 1616 | 201763_s_at | 0.8885 | 0.0353 | |
| GSE20347 | DAXX | 1616 | 201763_s_at | 0.2957 | 0.0193 | |
| GSE23400 | DAXX | 1616 | 216038_x_at | 0.0352 | 0.3468 | |
| GSE26886 | DAXX | 1616 | 201763_s_at | 0.0597 | 0.7608 | |
| GSE29001 | DAXX | 1616 | 216038_x_at | -0.0171 | 0.9041 | |
| GSE38129 | DAXX | 1616 | 201763_s_at | 0.4377 | 0.0000 | |
| GSE45670 | DAXX | 1616 | 201763_s_at | 0.3002 | 0.0203 | |
| GSE53622 | DAXX | 1616 | 2844 | 0.4210 | 0.0000 | |
| GSE53624 | DAXX | 1616 | 29575 | 0.4801 | 0.0000 | |
| GSE63941 | DAXX | 1616 | 201763_s_at | 0.8327 | 0.0072 | |
| GSE77861 | DAXX | 1616 | 201763_s_at | 0.1587 | 0.3039 | |
| GSE97050 | DAXX | 1616 | A_23_P122579 | 0.2877 | 0.1849 | |
| SRP007169 | DAXX | 1616 | RNAseq | 1.4869 | 0.0033 | |
| SRP008496 | DAXX | 1616 | RNAseq | 1.6792 | 0.0001 | |
| SRP064894 | DAXX | 1616 | RNAseq | 0.6843 | 0.0001 | |
| SRP133303 | DAXX | 1616 | RNAseq | 0.3067 | 0.0475 | |
| SRP159526 | DAXX | 1616 | RNAseq | 0.2699 | 0.1189 | |
| SRP193095 | DAXX | 1616 | RNAseq | 0.3191 | 0.0001 | |
| SRP219564 | DAXX | 1616 | RNAseq | 0.1335 | 0.4938 | |
| TCGA | DAXX | 1616 | RNAseq | 0.1484 | 0.0021 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by DAXX expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DAXX:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DAXX | 1616 | 5 | 0 | 25 | |
| GSE20123 | DAXX | 1616 | 5 | 0 | 25 | |
| GSE43470 | DAXX | 1616 | 4 | 1 | 38 | |
| GSE46452 | DAXX | 1616 | 2 | 9 | 48 | |
| GSE47630 | DAXX | 1616 | 8 | 4 | 28 | |
| GSE54993 | DAXX | 1616 | 3 | 1 | 66 | |
| GSE54994 | DAXX | 1616 | 11 | 4 | 38 | |
| GSE60625 | DAXX | 1616 | 1 | 0 | 10 | |
| GSE74703 | DAXX | 1616 | 4 | 0 | 32 | |
| GSE74704 | DAXX | 1616 | 2 | 0 | 18 | |
| TCGA | DAXX | 1616 | 15 | 16 | 65 |
Total number of gains: 60; Total number of losses: 35; Total Number of normals: 393.
Somatic mutations of DAXX:
Generating mutation plots.
Highly correlated genes for DAXX:
Showing top 20/728 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DAXX | TMPO-AS1 | 0.715109 | 3 | 0 | 3 |
| DAXX | MCM3 | 0.68232 | 8 | 0 | 7 |
| DAXX | TXNRD2 | 0.678179 | 4 | 0 | 3 |
| DAXX | MRPL14 | 0.670903 | 6 | 0 | 5 |
| DAXX | NUP62 | 0.669652 | 7 | 0 | 7 |
| DAXX | XPO5 | 0.668624 | 7 | 0 | 6 |
| DAXX | NRM | 0.662617 | 7 | 0 | 5 |
| DAXX | TMEM177 | 0.659063 | 7 | 0 | 6 |
| DAXX | UBE2C | 0.658246 | 8 | 0 | 7 |
| DAXX | MCM5 | 0.653607 | 7 | 0 | 5 |
| DAXX | ABCF1 | 0.651553 | 8 | 0 | 6 |
| DAXX | SRRT | 0.648749 | 6 | 0 | 5 |
| DAXX | TNFAIP8L1 | 0.646702 | 4 | 0 | 4 |
| DAXX | TRIM27 | 0.646676 | 7 | 0 | 5 |
| DAXX | BCAT2 | 0.64592 | 5 | 0 | 4 |
| DAXX | UBE2T | 0.644867 | 7 | 0 | 6 |
| DAXX | GMNN | 0.642896 | 9 | 0 | 8 |
| DAXX | NUP155 | 0.642671 | 7 | 0 | 5 |
| DAXX | LEMD2 | 0.642329 | 5 | 0 | 4 |
| DAXX | C1orf112 | 0.638284 | 7 | 0 | 7 |
For details and further investigation, click here
