POLRMT

 

Full name: RNA polymerase mitochondrial Alias Symbol: h-mtRPOL|APOLMT|MTRNAP|MTRPOL
Type: protein-coding gene Cytoband: 19p13.3
Entrez ID: 5442 HGNC ID: HGNC:9200 Ensembl Gene: ENSG00000099821 OMIM ID: 601778
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 84/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of POLRMT:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 POLRMT 5442 203782_s_at 0.5470 0.3212
GSE20347 POLRMT 5442 203782_s_at 0.0477 0.7992
GSE23400 POLRMT 5442 203782_s_at 0.1268 0.0791
GSE26886 POLRMT 5442 203782_s_at 0.6061 0.0001
GSE29001 POLRMT 5442 203782_s_at -0.1250 0.6706
GSE38129 POLRMT 5442 203782_s_at 0.0872 0.5146
GSE45670 POLRMT 5442 203782_s_at 0.2709 0.0941
GSE53622 POLRMT 5442 5740 -0.0565 0.5340
GSE53624 POLRMT 5442 5740 0.1562 0.0083
GSE63941 POLRMT 5442 203782_s_at 0.7343 0.0982
GSE77861 POLRMT 5442 203782_s_at 0.6623 0.0142
GSE97050 POLRMT 5442 A_23_P131096 0.1077 0.6516
SRP007169 POLRMT 5442 RNAseq -0.7442 0.0637
SRP008496 POLRMT 5442 RNAseq -0.4678 0.0455
SRP064894 POLRMT 5442 RNAseq 0.4922 0.0344
SRP133303 POLRMT 5442 RNAseq -0.2176 0.2013
SRP159526 POLRMT 5442 RNAseq 0.3563 0.0437
SRP193095 POLRMT 5442 RNAseq 0.1975 0.0658
SRP219564 POLRMT 5442 RNAseq 0.2690 0.2670
TCGA POLRMT 5442 RNAseq 0.0560 0.3135

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by POLRMT expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of POLRMT:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 POLRMT 5442 4 6 20
GSE20123 POLRMT 5442 4 5 21
GSE43470 POLRMT 5442 1 10 32
GSE46452 POLRMT 5442 47 1 11
GSE47630 POLRMT 5442 5 7 28
GSE54993 POLRMT 5442 13 4 53
GSE54994 POLRMT 5442 8 15 30
GSE60625 POLRMT 5442 9 0 2
GSE74703 POLRMT 5442 1 7 28
GSE74704 POLRMT 5442 3 3 14
TCGA POLRMT 5442 8 25 63

Total number of gains: 103; Total number of losses: 83; Total Number of normals: 302.  

 

Somatic mutations of POLRMT:

 

Generating mutation plots.

 

Highly correlated genes for POLRMT:

 

Showing top 20/1129 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
POLRMTNTPCR0.80921303
POLRMTZBED10.801168303
POLRMTRNFT20.787212404
POLRMTPATZ10.785932303
POLRMTHEATR60.778979303
POLRMTXPNPEP10.767301303
POLRMTLRP120.767073303
POLRMTATIC0.758489303
POLRMTB3GALT60.755274303
POLRMTSEL1L30.753317303
POLRMTPLEKHJ10.753137303
POLRMTRNF20.752117303
POLRMTGRIN2D0.751662303
POLRMTCHCHD60.744291505
POLRMTUBL50.742775404
POLRMTSRI0.742748303
POLRMTSLC39A130.741832303
POLRMTZNF7640.74085303
POLRMTABCB60.740317303
POLRMTPFN20.739163303

For details and further investigation, click here