TYK2

 

Full name: tyrosine kinase 2 Alias Symbol: JTK1
Type: protein-coding gene Cytoband: 19p13.2
Entrez ID: 7297 HGNC ID: HGNC:12440 Ensembl Gene: ENSG00000105397 OMIM ID: 176941
Drug and gene relationship at DGIdb

 

TYK2 involved pathways:

KEGG pathway Description View
hsa04380Osteoclast differentiation
hsa04630Jak-STAT signaling pathway
hsa05145Toxoplasmosis
hsa05160Hepatitis C
hsa05162Measles
hsa05164Influenza A
hsa05168Herpes simplex infection
hsa05169Epstein-Barr virus infection

 

Expression of TYK2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TYK2 7297 205546_s_at 0.6610 0.1030
GSE20347 TYK2 7297 205546_s_at 0.4698 0.0017
GSE23400 TYK2 7297 205546_s_at 0.5521 0.0000
GSE26886 TYK2 7297 205546_s_at 0.7828 0.0001
GSE29001 TYK2 7297 205546_s_at 0.6020 0.0254
GSE38129 TYK2 7297 205546_s_at 0.4328 0.0002
GSE45670 TYK2 7297 205546_s_at 0.3823 0.0053
GSE53622 TYK2 7297 44375 0.5146 0.0000
GSE53624 TYK2 7297 44375 0.7437 0.0000
GSE63941 TYK2 7297 205546_s_at -0.1495 0.6223
GSE77861 TYK2 7297 205546_s_at 0.6454 0.0008
GSE97050 TYK2 7297 A_23_P141917 0.4651 0.2622
SRP007169 TYK2 7297 RNAseq 0.6171 0.1050
SRP008496 TYK2 7297 RNAseq 0.7035 0.0019
SRP064894 TYK2 7297 RNAseq 0.8943 0.0000
SRP133303 TYK2 7297 RNAseq 0.3266 0.0163
SRP159526 TYK2 7297 RNAseq 0.5675 0.1537
SRP193095 TYK2 7297 RNAseq 0.6076 0.0000
SRP219564 TYK2 7297 RNAseq 1.0320 0.0048
TCGA TYK2 7297 RNAseq 0.0440 0.3422

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by TYK2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TYK2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TYK2 7297 4 3 23
GSE20123 TYK2 7297 3 1 26
GSE43470 TYK2 7297 3 6 34
GSE46452 TYK2 7297 47 1 11
GSE47630 TYK2 7297 4 7 29
GSE54993 TYK2 7297 16 3 51
GSE54994 TYK2 7297 7 13 33
GSE60625 TYK2 7297 9 0 2
GSE74703 TYK2 7297 3 4 29
GSE74704 TYK2 7297 0 1 19
TCGA TYK2 7297 14 15 67

Total number of gains: 110; Total number of losses: 54; Total Number of normals: 324.  

 

Somatic mutations of TYK2:

 

Generating mutation plots.

 

Highly correlated genes for TYK2:

 

Showing top 20/1610 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TYK2ZNF6280.739132404
TYK2IKBIP0.731911403
TYK2SSBP40.730477505
TYK2ZBED40.730112303
TYK2DNMT10.72917212011
TYK2KLHL130.726975303
TYK2RAD23A0.722446909
TYK2PLXNA10.72075512011
TYK2C21orf580.716685403
TYK2MED150.713837605
TYK2SRRT0.71125111011
TYK2CRTC20.709143606
TYK2TMTC40.70736403
TYK2ZNF5810.706995303
TYK2PA2G40.703674303
TYK2EME10.702168404
TYK2ILF30.7012512011
TYK2TRMT10.69929611011
TYK2ALKBH60.698893504
TYK2WDR810.698879504

For details and further investigation, click here