| Full name: tyrosinase related protein 1 | Alias Symbol: GP75|CATB|TRP|b-PROTEIN|OCA3 | ||
| Type: protein-coding gene | Cytoband: 9p23 | ||
| Entrez ID: 7306 | HGNC ID: HGNC:12450 | Ensembl Gene: ENSG00000107165 | OMIM ID: 115501 |
| Drug and gene relationship at DGIdb | |||
TYRP1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04916 | Melanogenesis |
Expression of TYRP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TYRP1 | 7306 | 205694_at | -0.0326 | 0.9881 | |
| GSE20347 | TYRP1 | 7306 | 205694_at | 0.0796 | 0.8071 | |
| GSE23400 | TYRP1 | 7306 | 205694_at | 0.0585 | 0.5019 | |
| GSE26886 | TYRP1 | 7306 | 205694_at | 1.6623 | 0.0162 | |
| GSE29001 | TYRP1 | 7306 | 205694_at | -0.3058 | 0.6361 | |
| GSE38129 | TYRP1 | 7306 | 205694_at | 0.0810 | 0.8566 | |
| GSE45670 | TYRP1 | 7306 | 205694_at | -1.4207 | 0.0032 | |
| GSE53622 | TYRP1 | 7306 | 49910 | -0.5529 | 0.0636 | |
| GSE53624 | TYRP1 | 7306 | 49910 | -0.7910 | 0.0026 | |
| GSE63941 | TYRP1 | 7306 | 205694_at | -2.0204 | 0.0655 | |
| GSE77861 | TYRP1 | 7306 | 205694_at | 0.2917 | 0.2030 | |
| GSE97050 | TYRP1 | 7306 | A_23_P94403 | 0.2256 | 0.4601 | |
| SRP064894 | TYRP1 | 7306 | RNAseq | 0.1779 | 0.7221 | |
| SRP159526 | TYRP1 | 7306 | RNAseq | -0.1796 | 0.8094 | |
| SRP219564 | TYRP1 | 7306 | RNAseq | 0.9585 | 0.3496 | |
| TCGA | TYRP1 | 7306 | RNAseq | -0.3665 | 0.2445 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by TYRP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TYRP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TYRP1 | 7306 | 2 | 14 | 14 | |
| GSE20123 | TYRP1 | 7306 | 2 | 14 | 14 | |
| GSE43470 | TYRP1 | 7306 | 4 | 11 | 28 | |
| GSE46452 | TYRP1 | 7306 | 2 | 23 | 34 | |
| GSE47630 | TYRP1 | 7306 | 4 | 26 | 10 | |
| GSE54993 | TYRP1 | 7306 | 6 | 3 | 61 | |
| GSE54994 | TYRP1 | 7306 | 10 | 16 | 27 | |
| GSE60625 | TYRP1 | 7306 | 0 | 0 | 11 | |
| GSE74703 | TYRP1 | 7306 | 4 | 8 | 24 | |
| GSE74704 | TYRP1 | 7306 | 0 | 10 | 10 | |
| TCGA | TYRP1 | 7306 | 14 | 50 | 32 |
Total number of gains: 48; Total number of losses: 175; Total Number of normals: 265.
Somatic mutations of TYRP1:
Generating mutation plots.
Highly correlated genes for TYRP1:
Showing top 20/194 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TYRP1 | EBF1 | 0.663599 | 4 | 0 | 4 |
| TYRP1 | LAYN | 0.652711 | 3 | 0 | 3 |
| TYRP1 | EVA1A | 0.651354 | 3 | 0 | 3 |
| TYRP1 | ACKR1 | 0.644354 | 4 | 0 | 3 |
| TYRP1 | MEST | 0.639512 | 3 | 0 | 3 |
| TYRP1 | OSR2 | 0.637967 | 3 | 0 | 3 |
| TYRP1 | RSPO3 | 0.634348 | 7 | 0 | 6 |
| TYRP1 | SMOC2 | 0.6308 | 6 | 0 | 4 |
| TYRP1 | PHF14 | 0.625378 | 3 | 0 | 3 |
| TYRP1 | LRRN4CL | 0.622984 | 5 | 0 | 5 |
| TYRP1 | CNN1 | 0.621817 | 7 | 0 | 6 |
| TYRP1 | NEXN | 0.61763 | 6 | 0 | 6 |
| TYRP1 | ECSCR | 0.6176 | 4 | 0 | 3 |
| TYRP1 | SERTAD4-AS1 | 0.613391 | 4 | 0 | 4 |
| TYRP1 | KLHL22 | 0.612204 | 3 | 0 | 3 |
| TYRP1 | CPD | 0.608548 | 5 | 0 | 3 |
| TYRP1 | C3orf70 | 0.607254 | 6 | 0 | 4 |
| TYRP1 | C11orf96 | 0.605754 | 3 | 0 | 3 |
| TYRP1 | PABPC5 | 0.605643 | 4 | 0 | 4 |
| TYRP1 | LINC00597 | 0.605285 | 3 | 0 | 3 |
For details and further investigation, click here
