| Full name: mesoderm specific transcript | Alias Symbol: PEG1 | ||
| Type: protein-coding gene | Cytoband: 7q32.2 | ||
| Entrez ID: 4232 | HGNC ID: HGNC:7028 | Ensembl Gene: ENSG00000106484 | OMIM ID: 601029 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MEST:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MEST | 4232 | 202016_at | 1.8122 | 0.0117 | |
| GSE20347 | MEST | 4232 | 202016_at | 2.3384 | 0.0000 | |
| GSE23400 | MEST | 4232 | 202016_at | 1.6827 | 0.0000 | |
| GSE26886 | MEST | 4232 | 202016_at | 1.6044 | 0.0060 | |
| GSE29001 | MEST | 4232 | 202016_at | 1.4726 | 0.0036 | |
| GSE38129 | MEST | 4232 | 202016_at | 2.4275 | 0.0000 | |
| GSE45670 | MEST | 4232 | 202016_at | 1.8390 | 0.0001 | |
| GSE53622 | MEST | 4232 | 20571 | 2.2103 | 0.0000 | |
| GSE53624 | MEST | 4232 | 20571 | 2.1199 | 0.0000 | |
| GSE63941 | MEST | 4232 | 202016_at | -0.4528 | 0.8675 | |
| GSE77861 | MEST | 4232 | 202016_at | 2.4710 | 0.0005 | |
| GSE97050 | MEST | 4232 | A_23_P156970 | 0.9984 | 0.2148 | |
| SRP007169 | MEST | 4232 | RNAseq | 2.8811 | 0.0000 | |
| SRP008496 | MEST | 4232 | RNAseq | 2.4570 | 0.0000 | |
| SRP064894 | MEST | 4232 | RNAseq | 2.1208 | 0.0000 | |
| SRP133303 | MEST | 4232 | RNAseq | 1.2975 | 0.0000 | |
| SRP159526 | MEST | 4232 | RNAseq | 2.9803 | 0.0000 | |
| SRP193095 | MEST | 4232 | RNAseq | 1.3829 | 0.0000 | |
| SRP219564 | MEST | 4232 | RNAseq | 2.3026 | 0.0002 | |
| TCGA | MEST | 4232 | RNAseq | 0.7088 | 0.0000 |
Upregulated datasets: 17; Downregulated datasets: 0.
Survival by MEST expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MEST:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MEST | 4232 | 8 | 1 | 21 | |
| GSE20123 | MEST | 4232 | 8 | 1 | 21 | |
| GSE43470 | MEST | 4232 | 2 | 3 | 38 | |
| GSE46452 | MEST | 4232 | 7 | 2 | 50 | |
| GSE47630 | MEST | 4232 | 7 | 4 | 29 | |
| GSE54993 | MEST | 4232 | 3 | 5 | 62 | |
| GSE54994 | MEST | 4232 | 7 | 7 | 39 | |
| GSE60625 | MEST | 4232 | 0 | 0 | 11 | |
| GSE74703 | MEST | 4232 | 2 | 3 | 31 | |
| GSE74704 | MEST | 4232 | 4 | 1 | 15 | |
| TCGA | MEST | 4232 | 28 | 21 | 47 |
Total number of gains: 76; Total number of losses: 48; Total Number of normals: 364.
Somatic mutations of MEST:
Generating mutation plots.
Highly correlated genes for MEST:
Showing top 20/1848 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MEST | CDCA5 | 0.823628 | 5 | 0 | 5 |
| MEST | PNPT1 | 0.802724 | 6 | 0 | 6 |
| MEST | ECT2 | 0.79546 | 11 | 0 | 10 |
| MEST | RUVBL1 | 0.795042 | 10 | 0 | 10 |
| MEST | TIMELESS | 0.788129 | 11 | 0 | 11 |
| MEST | UBE2T | 0.781779 | 7 | 0 | 7 |
| MEST | CKS1B | 0.779927 | 11 | 0 | 10 |
| MEST | RFC4 | 0.777635 | 11 | 0 | 10 |
| MEST | MCM2 | 0.769627 | 11 | 0 | 10 |
| MEST | CENPF | 0.767937 | 11 | 0 | 11 |
| MEST | CMSS1 | 0.759479 | 6 | 0 | 6 |
| MEST | TPX2 | 0.757725 | 11 | 0 | 11 |
| MEST | TNFAIP8L1 | 0.756394 | 4 | 0 | 4 |
| MEST | XPO1 | 0.753422 | 9 | 0 | 9 |
| MEST | HOXC9 | 0.751183 | 4 | 0 | 4 |
| MEST | BID | 0.75103 | 11 | 0 | 11 |
| MEST | KNTC1 | 0.749048 | 10 | 0 | 9 |
| MEST | CENPN | 0.746675 | 10 | 0 | 10 |
| MEST | TOP2A | 0.746168 | 11 | 0 | 11 |
| MEST | UHRF1 | 0.74539 | 7 | 0 | 6 |
For details and further investigation, click here
