| Full name: carboxypeptidase D | Alias Symbol: GP180 | ||
| Type: protein-coding gene | Cytoband: 17q11.2 | ||
| Entrez ID: 1362 | HGNC ID: HGNC:2301 | Ensembl Gene: ENSG00000108582 | OMIM ID: 603102 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CPD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CPD | 1362 | 201941_at | 0.3376 | 0.5783 | |
| GSE20347 | CPD | 1362 | 201941_at | -0.1187 | 0.6179 | |
| GSE23400 | CPD | 1362 | 201941_at | 0.4533 | 0.0000 | |
| GSE26886 | CPD | 1362 | 201941_at | 0.4045 | 0.2274 | |
| GSE29001 | CPD | 1362 | 201943_s_at | 0.2240 | 0.5456 | |
| GSE38129 | CPD | 1362 | 201941_at | 0.1448 | 0.4135 | |
| GSE45670 | CPD | 1362 | 201941_at | -0.0947 | 0.5951 | |
| GSE53622 | CPD | 1362 | 76461 | 0.4059 | 0.0001 | |
| GSE53624 | CPD | 1362 | 65101 | 0.0202 | 0.8443 | |
| GSE63941 | CPD | 1362 | 201941_at | -1.2118 | 0.0985 | |
| GSE77861 | CPD | 1362 | 201941_at | 0.5632 | 0.2165 | |
| GSE97050 | CPD | 1362 | A_24_P53282 | 0.4173 | 0.2589 | |
| SRP007169 | CPD | 1362 | RNAseq | 0.9945 | 0.0050 | |
| SRP008496 | CPD | 1362 | RNAseq | 1.0666 | 0.0000 | |
| SRP064894 | CPD | 1362 | RNAseq | 0.7178 | 0.0055 | |
| SRP133303 | CPD | 1362 | RNAseq | 0.3154 | 0.1286 | |
| SRP159526 | CPD | 1362 | RNAseq | 0.6879 | 0.0054 | |
| SRP193095 | CPD | 1362 | RNAseq | -0.1287 | 0.6074 | |
| SRP219564 | CPD | 1362 | RNAseq | 1.0705 | 0.0000 | |
| TCGA | CPD | 1362 | RNAseq | -0.1515 | 0.0060 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by CPD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CPD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CPD | 1362 | 7 | 2 | 21 | |
| GSE20123 | CPD | 1362 | 8 | 2 | 20 | |
| GSE43470 | CPD | 1362 | 0 | 1 | 42 | |
| GSE46452 | CPD | 1362 | 33 | 1 | 25 | |
| GSE47630 | CPD | 1362 | 7 | 1 | 32 | |
| GSE54993 | CPD | 1362 | 2 | 3 | 65 | |
| GSE54994 | CPD | 1362 | 7 | 6 | 40 | |
| GSE60625 | CPD | 1362 | 4 | 0 | 7 | |
| GSE74703 | CPD | 1362 | 0 | 1 | 35 | |
| GSE74704 | CPD | 1362 | 5 | 2 | 13 | |
| TCGA | CPD | 1362 | 20 | 10 | 66 |
Total number of gains: 93; Total number of losses: 29; Total Number of normals: 366.
Somatic mutations of CPD:
Generating mutation plots.
Highly correlated genes for CPD:
Showing top 20/78 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CPD | CAPRIN2 | 0.671933 | 3 | 0 | 3 |
| CPD | ZNF18 | 0.639125 | 3 | 0 | 3 |
| CPD | GPN1 | 0.611937 | 3 | 0 | 3 |
| CPD | TYRP1 | 0.608548 | 5 | 0 | 3 |
| CPD | NHLRC3 | 0.60183 | 5 | 0 | 3 |
| CPD | HPS3 | 0.597034 | 4 | 0 | 3 |
| CPD | LEF1 | 0.57216 | 4 | 0 | 4 |
| CPD | NOL4L | 0.571089 | 4 | 0 | 3 |
| CPD | RAB20 | 0.567039 | 5 | 0 | 3 |
| CPD | SLFN11 | 0.565258 | 5 | 0 | 4 |
| CPD | SGTB | 0.563837 | 3 | 0 | 3 |
| CPD | MMP2 | 0.559486 | 4 | 0 | 3 |
| CPD | TMA16 | 0.559316 | 4 | 0 | 3 |
| CPD | AGT | 0.556727 | 6 | 0 | 4 |
| CPD | L3MBTL3 | 0.556314 | 6 | 0 | 5 |
| CPD | STEAP2 | 0.55585 | 7 | 0 | 4 |
| CPD | RILPL2 | 0.55492 | 6 | 0 | 3 |
| CPD | TTC39C | 0.553751 | 4 | 0 | 3 |
| CPD | FARP1 | 0.552496 | 5 | 0 | 3 |
| CPD | MIS12 | 0.551168 | 5 | 0 | 3 |
For details and further investigation, click here
