| Full name: unc-51 like autophagy activating kinase 2 | Alias Symbol: KIAA0623|Unc51.2|ATG1B | ||
| Type: protein-coding gene | Cytoband: 17p11.2 | ||
| Entrez ID: 9706 | HGNC ID: HGNC:13480 | Ensembl Gene: ENSG00000083290 | OMIM ID: 608650 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
ULK2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04211 | Longevity regulating pathway - mammal |
Expression of ULK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ULK2 | 9706 | 204062_s_at | -0.1492 | 0.8337 | |
| GSE20347 | ULK2 | 9706 | 204062_s_at | 0.2727 | 0.1224 | |
| GSE23400 | ULK2 | 9706 | 204062_s_at | 0.1246 | 0.1068 | |
| GSE26886 | ULK2 | 9706 | 215154_at | 0.0996 | 0.3813 | |
| GSE29001 | ULK2 | 9706 | 204063_s_at | 0.2135 | 0.5113 | |
| GSE38129 | ULK2 | 9706 | 204062_s_at | 0.1694 | 0.3695 | |
| GSE45670 | ULK2 | 9706 | 204062_s_at | -0.0745 | 0.8307 | |
| GSE53622 | ULK2 | 9706 | 2486 | 0.0531 | 0.5054 | |
| GSE53624 | ULK2 | 9706 | 2486 | -0.0705 | 0.3486 | |
| GSE63941 | ULK2 | 9706 | 204062_s_at | -2.2597 | 0.0323 | |
| GSE77861 | ULK2 | 9706 | 204062_s_at | 0.1896 | 0.5529 | |
| GSE97050 | ULK2 | 9706 | A_23_P55107 | -0.3745 | 0.2540 | |
| SRP007169 | ULK2 | 9706 | RNAseq | 0.4305 | 0.4170 | |
| SRP008496 | ULK2 | 9706 | RNAseq | 1.0967 | 0.0261 | |
| SRP064894 | ULK2 | 9706 | RNAseq | 0.7512 | 0.0058 | |
| SRP133303 | ULK2 | 9706 | RNAseq | 0.1190 | 0.5854 | |
| SRP159526 | ULK2 | 9706 | RNAseq | 0.4676 | 0.1664 | |
| SRP193095 | ULK2 | 9706 | RNAseq | 0.1885 | 0.1252 | |
| SRP219564 | ULK2 | 9706 | RNAseq | 0.1534 | 0.7687 | |
| TCGA | ULK2 | 9706 | RNAseq | -0.1436 | 0.0326 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by ULK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ULK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ULK2 | 9706 | 3 | 3 | 24 | |
| GSE20123 | ULK2 | 9706 | 3 | 4 | 23 | |
| GSE43470 | ULK2 | 9706 | 1 | 5 | 37 | |
| GSE46452 | ULK2 | 9706 | 34 | 1 | 24 | |
| GSE47630 | ULK2 | 9706 | 7 | 1 | 32 | |
| GSE54993 | ULK2 | 9706 | 3 | 3 | 64 | |
| GSE54994 | ULK2 | 9706 | 7 | 6 | 40 | |
| GSE60625 | ULK2 | 9706 | 4 | 0 | 7 | |
| GSE74703 | ULK2 | 9706 | 1 | 2 | 33 | |
| GSE74704 | ULK2 | 9706 | 2 | 1 | 17 | |
| TCGA | ULK2 | 9706 | 18 | 24 | 54 |
Total number of gains: 83; Total number of losses: 50; Total Number of normals: 355.
Somatic mutations of ULK2:
Generating mutation plots.
Highly correlated genes for ULK2:
Showing top 20/97 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ULK2 | CDHR3 | 0.783818 | 3 | 0 | 3 |
| ULK2 | SHISA3 | 0.70471 | 3 | 0 | 3 |
| ULK2 | PLA2G12B | 0.691162 | 3 | 0 | 3 |
| ULK2 | OR2T27 | 0.690883 | 3 | 0 | 3 |
| ULK2 | DCDC1 | 0.684271 | 3 | 0 | 3 |
| ULK2 | TOX2 | 0.668684 | 4 | 0 | 3 |
| ULK2 | BBC3 | 0.664999 | 3 | 0 | 3 |
| ULK2 | OR2T1 | 0.662082 | 3 | 0 | 3 |
| ULK2 | SHISA6 | 0.645859 | 3 | 0 | 3 |
| ULK2 | TTC21A | 0.641865 | 3 | 0 | 3 |
| ULK2 | TMEM174 | 0.629102 | 5 | 0 | 5 |
| ULK2 | TOR1AIP1 | 0.626995 | 5 | 0 | 4 |
| ULK2 | YY2 | 0.624863 | 3 | 0 | 3 |
| ULK2 | SEC62 | 0.623785 | 4 | 0 | 3 |
| ULK2 | RNF216 | 0.620251 | 4 | 0 | 3 |
| ULK2 | CBLN3 | 0.620088 | 3 | 0 | 3 |
| ULK2 | GYPE | 0.619412 | 4 | 0 | 4 |
| ULK2 | CHST10 | 0.610756 | 5 | 0 | 5 |
| ULK2 | RPRM | 0.610546 | 4 | 0 | 3 |
| ULK2 | TMEM229A | 0.609883 | 3 | 0 | 3 |
For details and further investigation, click here
