KMT2D

 

Full name: lysine methyltransferase 2D Alias Symbol: ALR|MLL4|CAGL114
Type: protein-coding gene Cytoband: 12q13.12
Entrez ID: 8085 HGNC ID: HGNC:7133 Ensembl Gene: ENSG00000167548 OMIM ID: 602113
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 26/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of KMT2D:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 KMT2D 8085 227527_at 0.2745 0.6363
GSE20347 KMT2D 8085 216845_x_at -0.0926 0.3395
GSE26886 KMT2D 8085 227527_at 0.1157 0.6977
GSE38129 KMT2D 8085 216845_x_at -0.0881 0.3336
GSE45670 KMT2D 8085 227527_at -0.1178 0.3876
GSE53622 KMT2D 8085 14186 -1.9112 0.0000
GSE53624 KMT2D 8085 14186 -3.1788 0.0000
GSE63941 KMT2D 8085 227527_at -0.0913 0.8335
GSE77861 KMT2D 8085 216845_x_at -0.1614 0.2573
SRP007169 KMT2D 8085 RNAseq 0.9310 0.0070
SRP008496 KMT2D 8085 RNAseq 0.6043 0.0031
SRP064894 KMT2D 8085 RNAseq -0.1337 0.6724
SRP133303 KMT2D 8085 RNAseq -0.0114 0.9397
SRP159526 KMT2D 8085 RNAseq 0.1717 0.5095
SRP193095 KMT2D 8085 RNAseq 0.2333 0.1298
SRP219564 KMT2D 8085 RNAseq -0.2043 0.5330

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by KMT2D expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of KMT2D:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 KMT2D 8085 6 1 23
GSE20123 KMT2D 8085 6 1 23
GSE43470 KMT2D 8085 4 1 38
GSE46452 KMT2D 8085 8 1 50
GSE47630 KMT2D 8085 11 2 27
GSE54993 KMT2D 8085 0 5 65
GSE54994 KMT2D 8085 4 1 48
GSE60625 KMT2D 8085 0 0 11
GSE74703 KMT2D 8085 4 1 31
GSE74704 KMT2D 8085 4 1 15
TCGA KMT2D 8085 16 15 65

Total number of gains: 63; Total number of losses: 29; Total Number of normals: 396.  

 

Somatic mutations of KMT2D:

 

Generating mutation plots.

 

Highly correlated genes for KMT2D:

 

Showing top 20/354 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
KMT2DDEGS20.814915303
KMT2DMORN30.791486303
KMT2DPLEKHN10.781908303
KMT2DS100A140.767762303
KMT2DTMEM9B0.765523303
KMT2DSERPINB60.763031303
KMT2DETHE10.762639303
KMT2DRNF1410.759976303
KMT2DNANOS20.747533303
KMT2DTOLLIP0.747262303
KMT2DCSTL10.746904303
KMT2DHIC20.744656404
KMT2DTECPR10.743175303
KMT2DC1orf1160.741181303
KMT2DASPG0.731911303
KMT2DSCNN1B0.730772303
KMT2DABHD50.729563303
KMT2DACER10.72809303
KMT2DNAGK0.726859303
KMT2DBNIPL0.724786303

For details and further investigation, click here