UPP1

 

Full name: uridine phosphorylase 1 Alias Symbol: UPASE|UPP|UDRPASE
Type: protein-coding gene Cytoband: 7p12.3
Entrez ID: 7378 HGNC ID: HGNC:12576 Ensembl Gene: ENSG00000183696 OMIM ID: 191730
Drug and gene relationship at DGIdb

 

Expression of UPP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 UPP1 7378 203234_at -0.3800 0.8203
GSE20347 UPP1 7378 203234_at -1.1667 0.0060
GSE23400 UPP1 7378 203234_at -0.9618 0.0000
GSE26886 UPP1 7378 203234_at -1.9670 0.0001
GSE29001 UPP1 7378 203234_at -1.3528 0.0296
GSE38129 UPP1 7378 203234_at -0.5995 0.1459
GSE45670 UPP1 7378 203234_at 0.1079 0.8187
GSE53622 UPP1 7378 5118 -0.6066 0.0148
GSE53624 UPP1 7378 5118 -0.9427 0.0000
GSE63941 UPP1 7378 203234_at 0.5998 0.4772
GSE77861 UPP1 7378 203234_at -0.6578 0.2316
GSE97050 UPP1 7378 A_23_P147805 0.4111 0.6850
SRP007169 UPP1 7378 RNAseq -3.5461 0.0000
SRP008496 UPP1 7378 RNAseq -3.1986 0.0000
SRP064894 UPP1 7378 RNAseq -0.9269 0.0016
SRP133303 UPP1 7378 RNAseq -0.5498 0.1093
SRP159526 UPP1 7378 RNAseq -1.3540 0.0061
SRP193095 UPP1 7378 RNAseq -1.5508 0.0000
SRP219564 UPP1 7378 RNAseq -0.2102 0.7643
TCGA UPP1 7378 RNAseq 0.5975 0.0001

Upregulated datasets: 0; Downregulated datasets: 7.  

 

Survival by UPP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of UPP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 UPP1 7378 13 0 17
GSE20123 UPP1 7378 12 0 18
GSE43470 UPP1 7378 4 0 39
GSE46452 UPP1 7378 11 1 47
GSE47630 UPP1 7378 8 1 31
GSE54993 UPP1 7378 0 8 62
GSE54994 UPP1 7378 16 3 34
GSE60625 UPP1 7378 0 0 11
GSE74703 UPP1 7378 4 0 32
GSE74704 UPP1 7378 6 0 14
TCGA UPP1 7378 51 8 37

Total number of gains: 125; Total number of losses: 21; Total Number of normals: 342.  

 

Somatic mutations of UPP1:

 

Generating mutation plots.

 

Highly correlated genes for UPP1:

 

Showing top 20/674 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
UPP1DNASE1L10.737043404
UPP1RNASE70.734077808
UPP1S100A100.72737712010
UPP1IFI27L10.724547303
UPP1CDA0.72392511010
UPP1GNA150.72120612011
UPP1ZBED20.70946312010
UPP1SLC10A60.709095303
UPP1KRT6C0.7028403
UPP1METRNL0.700345605
UPP1IL1A0.69366711010
UPP1RHOD0.69023513012
UPP1BTBD110.688686606
UPP1GJB20.686846605
UPP1SBSN0.683682808
UPP1KRT750.682935404
UPP1KCNK60.68269606
UPP1AREG0.68137909
UPP1IL36RN0.6800361009
UPP1ARNTL20.67959311010

For details and further investigation, click here