IL1A

 

Full name: interleukin 1 alpha Alias Symbol: IL1F1|IL-1A|IL1-ALPHA
Type: protein-coding gene Cytoband: 2q14.1
Entrez ID: 3552 HGNC ID: HGNC:5991 Ensembl Gene: ENSG00000115008 OMIM ID: 147760
Drug and gene relationship at DGIdb

 

IL1A involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04380Osteoclast differentiation
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05133Pertussis
hsa05152Tuberculosis

 

Expression of IL1A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IL1A 3552 210118_s_at 0.5791 0.8687
GSE20347 IL1A 3552 210118_s_at -1.3406 0.0085
GSE23400 IL1A 3552 210118_s_at -0.7408 0.0005
GSE26886 IL1A 3552 210118_s_at -2.4757 0.0010
GSE29001 IL1A 3552 208200_at 0.2241 0.6051
GSE38129 IL1A 3552 210118_s_at -0.7323 0.1636
GSE45670 IL1A 3552 210118_s_at 0.4242 0.5898
GSE53622 IL1A 3552 12234 -0.2613 0.5282
GSE53624 IL1A 3552 12234 -1.5217 0.0000
GSE63941 IL1A 3552 210118_s_at 2.8867 0.1169
GSE77861 IL1A 3552 210118_s_at 0.1832 0.8755
GSE97050 IL1A 3552 A_23_P72096 0.7020 0.5901
SRP007169 IL1A 3552 RNAseq -4.9691 0.0000
SRP008496 IL1A 3552 RNAseq -3.9888 0.0000
SRP064894 IL1A 3552 RNAseq -1.5244 0.0050
SRP133303 IL1A 3552 RNAseq 0.3025 0.6064
SRP159526 IL1A 3552 RNAseq -3.4862 0.0000
SRP193095 IL1A 3552 RNAseq 0.4824 0.3693
SRP219564 IL1A 3552 RNAseq -0.6899 0.6189
TCGA IL1A 3552 RNAseq 1.9079 0.0000

Upregulated datasets: 1; Downregulated datasets: 7.  

 

Survival by IL1A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IL1A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IL1A 3552 6 2 22
GSE20123 IL1A 3552 6 2 22
GSE43470 IL1A 3552 3 1 39
GSE46452 IL1A 3552 1 4 54
GSE47630 IL1A 3552 7 0 33
GSE54993 IL1A 3552 0 6 64
GSE54994 IL1A 3552 10 0 43
GSE60625 IL1A 3552 0 3 8
GSE74703 IL1A 3552 3 1 32
GSE74704 IL1A 3552 3 2 15
TCGA IL1A 3552 31 6 59

Total number of gains: 70; Total number of losses: 27; Total Number of normals: 391.  

 

Somatic mutations of IL1A:

 

Generating mutation plots.

 

Highly correlated genes for IL1A:

 

Showing top 20/318 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IL1AARNTL20.704487909
IL1AS100A160.698643404
IL1AUPP10.69366711010
IL1AFAM83C0.665662403
IL1AUSP430.665595606
IL1AGNA150.6588621109
IL1AVTA10.654409303
IL1AZBED20.6486011009
IL1ARNASE70.644403706
IL1ADMKN0.641732605
IL1ASH3RF20.641567707
IL1ANABP10.640055907
IL1ALPAR50.636798503
IL1AIL20RB0.630467705
IL1AAREG0.6292061008
IL1AKRT6C0.626839403
IL1AEPHA20.62506810010
IL1ASH3GL10.624179707
IL1ALALBA0.615755303
IL1AC16orf870.609334403

For details and further investigation, click here