| Full name: interleukin 36 receptor antagonist | Alias Symbol: FIL1|FIL1(DELTA)|FIL1D|IL1HY1|IL1RP3|IL1L1|IL-1F5|IL36RA|MGC29840 | ||
| Type: protein-coding gene | Cytoband: 2q14.1 | ||
| Entrez ID: 26525 | HGNC ID: HGNC:15561 | Ensembl Gene: ENSG00000136695 | OMIM ID: 605507 |
| Drug and gene relationship at DGIdb | |||
Expression of IL36RN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL36RN | 26525 | 222223_s_at | -0.0471 | 0.9875 | |
| GSE20347 | IL36RN | 26525 | 222223_s_at | -1.2890 | 0.0002 | |
| GSE23400 | IL36RN | 26525 | 222223_s_at | -0.4246 | 0.0004 | |
| GSE26886 | IL36RN | 26525 | 222223_s_at | -3.0061 | 0.0000 | |
| GSE29001 | IL36RN | 26525 | 222223_s_at | -1.5888 | 0.0057 | |
| GSE38129 | IL36RN | 26525 | 222223_s_at | -0.9276 | 0.0228 | |
| GSE45670 | IL36RN | 26525 | 222223_s_at | 1.0479 | 0.0087 | |
| GSE53622 | IL36RN | 26525 | 121482 | -0.7693 | 0.0413 | |
| GSE53624 | IL36RN | 26525 | 121482 | -1.6850 | 0.0000 | |
| GSE63941 | IL36RN | 26525 | 222223_s_at | 0.7465 | 0.3080 | |
| GSE77861 | IL36RN | 26525 | 222223_s_at | 0.0245 | 0.9706 | |
| SRP007169 | IL36RN | 26525 | RNAseq | -3.4222 | 0.0000 | |
| SRP008496 | IL36RN | 26525 | RNAseq | -2.8830 | 0.0000 | |
| SRP064894 | IL36RN | 26525 | RNAseq | -1.5939 | 0.0130 | |
| SRP133303 | IL36RN | 26525 | RNAseq | -0.7642 | 0.3851 | |
| SRP159526 | IL36RN | 26525 | RNAseq | -1.7072 | 0.1401 | |
| SRP219564 | IL36RN | 26525 | RNAseq | -4.3314 | 0.0002 |
Upregulated datasets: 1; Downregulated datasets: 8.
Survival by IL36RN expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of IL36RN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL36RN | 26525 | 7 | 2 | 21 | |
| GSE20123 | IL36RN | 26525 | 7 | 2 | 21 | |
| GSE43470 | IL36RN | 26525 | 3 | 1 | 39 | |
| GSE46452 | IL36RN | 26525 | 1 | 4 | 54 | |
| GSE47630 | IL36RN | 26525 | 7 | 0 | 33 | |
| GSE54993 | IL36RN | 26525 | 0 | 6 | 64 | |
| GSE54994 | IL36RN | 26525 | 10 | 0 | 43 | |
| GSE60625 | IL36RN | 26525 | 0 | 3 | 8 | |
| GSE74703 | IL36RN | 26525 | 3 | 1 | 32 | |
| GSE74704 | IL36RN | 26525 | 3 | 2 | 15 | |
| TCGA | IL36RN | 26525 | 31 | 6 | 59 |
Total number of gains: 72; Total number of losses: 27; Total Number of normals: 389.
Somatic mutations of IL36RN:
Generating mutation plots.
Highly correlated genes for IL36RN:
Showing top 20/751 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL36RN | TGM1 | 0.798562 | 8 | 0 | 8 |
| IL36RN | SDR9C7 | 0.797797 | 5 | 0 | 5 |
| IL36RN | TMPRSS11D | 0.775052 | 8 | 0 | 8 |
| IL36RN | TMEM45B | 0.77049 | 5 | 0 | 5 |
| IL36RN | KLK7 | 0.755461 | 9 | 0 | 9 |
| IL36RN | SPRR1B | 0.743213 | 10 | 0 | 10 |
| IL36RN | IL22RA1 | 0.740776 | 7 | 0 | 7 |
| IL36RN | LCE3D | 0.740558 | 5 | 0 | 5 |
| IL36RN | IL20RB | 0.733289 | 4 | 0 | 4 |
| IL36RN | IVL | 0.728548 | 9 | 0 | 9 |
| IL36RN | PI3 | 0.726365 | 10 | 0 | 10 |
| IL36RN | TMEM40 | 0.724409 | 8 | 0 | 8 |
| IL36RN | CRCT1 | 0.724338 | 8 | 0 | 8 |
| IL36RN | S100A12 | 0.724097 | 10 | 0 | 9 |
| IL36RN | KRT80 | 0.723316 | 6 | 0 | 5 |
| IL36RN | LYPD3 | 0.721305 | 8 | 0 | 8 |
| IL36RN | KLK10 | 0.721206 | 8 | 0 | 8 |
| IL36RN | PRSS3 | 0.715752 | 8 | 0 | 7 |
| IL36RN | GRHL3 | 0.715033 | 4 | 0 | 3 |
| IL36RN | TMEM154 | 0.708766 | 4 | 0 | 4 |
For details and further investigation, click here
