| Full name: amphiregulin | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4q13.3 | ||
| Entrez ID: 374 | HGNC ID: HGNC:651 | Ensembl Gene: ENSG00000109321 | OMIM ID: 104640 |
| Drug and gene relationship at DGIdb | |||
AREG involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04012 | ErbB signaling pathway | |
| hsa04390 | Hippo signaling pathway |
Expression of AREG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AREG | 374 | 205239_at | -1.3961 | 0.5355 | |
| GSE20347 | AREG | 374 | 205239_at | -1.9932 | 0.0002 | |
| GSE23400 | AREG | 374 | 205239_at | -1.1211 | 0.0000 | |
| GSE26886 | AREG | 374 | 205239_at | -1.2392 | 0.1325 | |
| GSE29001 | AREG | 374 | 205239_at | -2.0655 | 0.0056 | |
| GSE38129 | AREG | 374 | 205239_at | -1.1296 | 0.0136 | |
| GSE45670 | AREG | 374 | 205239_at | -0.0737 | 0.9074 | |
| GSE53622 | AREG | 374 | 137334 | -0.7935 | 0.0015 | |
| GSE53624 | AREG | 374 | 137334 | -1.0474 | 0.0000 | |
| GSE63941 | AREG | 374 | 205239_at | 0.5835 | 0.7567 | |
| GSE77861 | AREG | 374 | 205239_at | -0.5788 | 0.3385 | |
| GSE97050 | AREG | 374 | A_33_P3419190 | 0.2773 | 0.6699 | |
| SRP007169 | AREG | 374 | RNAseq | -1.5681 | 0.0014 | |
| SRP008496 | AREG | 374 | RNAseq | -1.2671 | 0.0047 | |
| SRP064894 | AREG | 374 | RNAseq | 0.1415 | 0.7441 | |
| SRP133303 | AREG | 374 | RNAseq | 1.1562 | 0.0124 | |
| SRP159526 | AREG | 374 | RNAseq | -0.8336 | 0.0637 | |
| SRP193095 | AREG | 374 | RNAseq | -0.1195 | 0.7082 | |
| SRP219564 | AREG | 374 | RNAseq | -1.0974 | 0.2415 | |
| TCGA | AREG | 374 | RNAseq | 0.1350 | 0.5850 |
Upregulated datasets: 1; Downregulated datasets: 7.
Survival by AREG expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AREG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AREG | 374 | 2 | 9 | 19 | |
| GSE20123 | AREG | 374 | 2 | 9 | 19 | |
| GSE43470 | AREG | 374 | 0 | 13 | 30 | |
| GSE46452 | AREG | 374 | 3 | 34 | 22 | |
| GSE47630 | AREG | 374 | 1 | 19 | 20 | |
| GSE54993 | AREG | 374 | 7 | 0 | 63 | |
| GSE54994 | AREG | 374 | 1 | 9 | 43 | |
| GSE60625 | AREG | 374 | 0 | 0 | 11 | |
| GSE74703 | AREG | 374 | 0 | 11 | 25 | |
| GSE74704 | AREG | 374 | 2 | 5 | 13 | |
| TCGA | AREG | 374 | 19 | 28 | 49 |
Total number of gains: 37; Total number of losses: 137; Total Number of normals: 314.
Somatic mutations of AREG:
Generating mutation plots.
Highly correlated genes for AREG:
Showing top 20/468 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AREG | SNX14 | 0.781537 | 3 | 0 | 3 |
| AREG | EREG | 0.718822 | 10 | 0 | 10 |
| AREG | UPP1 | 0.68137 | 9 | 0 | 9 |
| AREG | ZNF346 | 0.659955 | 3 | 0 | 3 |
| AREG | STAU2 | 0.657255 | 3 | 0 | 3 |
| AREG | CCNYL1 | 0.651695 | 3 | 0 | 3 |
| AREG | TUBB2A | 0.651391 | 10 | 0 | 10 |
| AREG | PHLDA1 | 0.650623 | 12 | 0 | 9 |
| AREG | RBKS | 0.647219 | 5 | 0 | 3 |
| AREG | ZNF101 | 0.646003 | 3 | 0 | 3 |
| AREG | MPI | 0.64415 | 4 | 0 | 3 |
| AREG | KCNK6 | 0.643981 | 5 | 0 | 5 |
| AREG | DNAJA2 | 0.642295 | 6 | 0 | 4 |
| AREG | RSL24D1 | 0.641209 | 3 | 0 | 3 |
| AREG | RAD50 | 0.64101 | 4 | 0 | 3 |
| AREG | S100A10 | 0.640688 | 10 | 0 | 9 |
| AREG | DLL1 | 0.640214 | 4 | 0 | 4 |
| AREG | OSBPL10 | 0.640019 | 9 | 0 | 8 |
| AREG | BCAS2 | 0.639867 | 3 | 0 | 3 |
| AREG | CAMK2D | 0.636177 | 7 | 0 | 5 |
For details and further investigation, click here
