| Full name: gap junction protein beta 2 | Alias Symbol: CX26|NSRD1 | ||
| Type: protein-coding gene | Cytoband: 13q12.11 | ||
| Entrez ID: 2706 | HGNC ID: HGNC:4284 | Ensembl Gene: ENSG00000165474 | OMIM ID: 121011 |
| Drug and gene relationship at DGIdb | |||
Expression of GJB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GJB2 | 2706 | 223278_at | -1.3073 | 0.4961 | |
| GSE26886 | GJB2 | 2706 | 223278_at | -2.4737 | 0.0001 | |
| GSE45670 | GJB2 | 2706 | 223278_at | 0.1222 | 0.5521 | |
| GSE63941 | GJB2 | 2706 | 223278_at | 3.4466 | 0.0293 | |
| GSE77861 | GJB2 | 2706 | 223278_at | -0.8999 | 0.1521 | |
| GSE97050 | GJB2 | 2706 | A_23_P204947 | 0.2973 | 0.8069 | |
| SRP007169 | GJB2 | 2706 | RNAseq | -3.4046 | 0.0000 | |
| SRP008496 | GJB2 | 2706 | RNAseq | -2.0282 | 0.0012 | |
| SRP064894 | GJB2 | 2706 | RNAseq | -0.9911 | 0.0618 | |
| SRP133303 | GJB2 | 2706 | RNAseq | -1.3421 | 0.0021 | |
| SRP159526 | GJB2 | 2706 | RNAseq | -3.1933 | 0.0001 | |
| SRP193095 | GJB2 | 2706 | RNAseq | -1.2920 | 0.0070 | |
| SRP219564 | GJB2 | 2706 | RNAseq | -3.0067 | 0.0164 | |
| TCGA | GJB2 | 2706 | RNAseq | 0.8915 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 7.
Survival by GJB2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GJB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GJB2 | 2706 | 1 | 16 | 13 | |
| GSE20123 | GJB2 | 2706 | 1 | 15 | 14 | |
| GSE43470 | GJB2 | 2706 | 1 | 13 | 29 | |
| GSE46452 | GJB2 | 2706 | 0 | 33 | 26 | |
| GSE47630 | GJB2 | 2706 | 3 | 26 | 11 | |
| GSE54993 | GJB2 | 2706 | 11 | 2 | 57 | |
| GSE54994 | GJB2 | 2706 | 1 | 13 | 39 | |
| GSE60625 | GJB2 | 2706 | 0 | 3 | 8 | |
| GSE74703 | GJB2 | 2706 | 1 | 10 | 25 | |
| GSE74704 | GJB2 | 2706 | 0 | 13 | 7 | |
| TCGA | GJB2 | 2706 | 7 | 42 | 47 |
Total number of gains: 26; Total number of losses: 186; Total Number of normals: 276.
Somatic mutations of GJB2:
Generating mutation plots.
Highly correlated genes for GJB2:
Showing top 20/482 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GJB2 | NAMPT | 0.834314 | 3 | 0 | 3 |
| GJB2 | GJB6 | 0.832094 | 7 | 0 | 7 |
| GJB2 | SERINC5 | 0.811041 | 3 | 0 | 3 |
| GJB2 | SBSN | 0.776743 | 6 | 0 | 6 |
| GJB2 | DSC2 | 0.770243 | 7 | 0 | 7 |
| GJB2 | KRT6B | 0.746284 | 7 | 0 | 6 |
| GJB2 | GNA15 | 0.743698 | 7 | 0 | 7 |
| GJB2 | PPIC | 0.741601 | 4 | 0 | 4 |
| GJB2 | BTBD11 | 0.741172 | 5 | 0 | 5 |
| GJB2 | KCNK6 | 0.740506 | 5 | 0 | 5 |
| GJB2 | S100A9 | 0.733451 | 7 | 0 | 6 |
| GJB2 | ARNTL2 | 0.730311 | 4 | 0 | 3 |
| GJB2 | OSBPL10 | 0.729315 | 4 | 0 | 3 |
| GJB2 | IL20RB | 0.728833 | 6 | 0 | 6 |
| GJB2 | IL18 | 0.725697 | 4 | 0 | 4 |
| GJB2 | HPSE | 0.721264 | 4 | 0 | 4 |
| GJB2 | S100A8 | 0.718226 | 7 | 0 | 7 |
| GJB2 | CEACAM7 | 0.716578 | 4 | 0 | 3 |
| GJB2 | CWH43 | 0.713878 | 4 | 0 | 4 |
| GJB2 | LYPD3 | 0.710327 | 7 | 0 | 6 |
For details and further investigation, click here
