| Full name: NADH:ubiquinone oxidoreductase subunit A2 | Alias Symbol: B8 | ||
| Type: protein-coding gene | Cytoband: 5q31.3 | ||
| Entrez ID: 4695 | HGNC ID: HGNC:7685 | Ensembl Gene: ENSG00000131495 | OMIM ID: 602137 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NDUFA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NDUFA2 | 4695 | 209224_s_at | -0.0887 | 0.7134 | |
| GSE20347 | NDUFA2 | 4695 | 209224_s_at | -0.3237 | 0.0445 | |
| GSE23400 | NDUFA2 | 4695 | 209224_s_at | -0.1860 | 0.0383 | |
| GSE26886 | NDUFA2 | 4695 | 209224_s_at | 0.4155 | 0.0225 | |
| GSE29001 | NDUFA2 | 4695 | 209224_s_at | -0.7543 | 0.0522 | |
| GSE38129 | NDUFA2 | 4695 | 209224_s_at | -0.2790 | 0.0237 | |
| GSE45670 | NDUFA2 | 4695 | 209224_s_at | -0.2157 | 0.0951 | |
| GSE53622 | NDUFA2 | 4695 | 82738 | -0.4342 | 0.0000 | |
| GSE53624 | NDUFA2 | 4695 | 82738 | -0.2933 | 0.0000 | |
| GSE63941 | NDUFA2 | 4695 | 209224_s_at | 0.2516 | 0.5547 | |
| GSE77861 | NDUFA2 | 4695 | 209224_s_at | -0.5229 | 0.0140 | |
| GSE97050 | NDUFA2 | 4695 | A_23_P257795 | -0.2388 | 0.3035 | |
| SRP007169 | NDUFA2 | 4695 | RNAseq | -1.7225 | 0.0000 | |
| SRP008496 | NDUFA2 | 4695 | RNAseq | -1.6373 | 0.0000 | |
| SRP064894 | NDUFA2 | 4695 | RNAseq | -0.1019 | 0.7579 | |
| SRP133303 | NDUFA2 | 4695 | RNAseq | 0.0849 | 0.7618 | |
| SRP159526 | NDUFA2 | 4695 | RNAseq | -0.3196 | 0.3788 | |
| SRP193095 | NDUFA2 | 4695 | RNAseq | -0.9054 | 0.0000 | |
| SRP219564 | NDUFA2 | 4695 | RNAseq | -0.1593 | 0.6230 | |
| TCGA | NDUFA2 | 4695 | RNAseq | -0.1166 | 0.0473 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by NDUFA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NDUFA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NDUFA2 | 4695 | 3 | 11 | 16 | |
| GSE20123 | NDUFA2 | 4695 | 4 | 11 | 15 | |
| GSE43470 | NDUFA2 | 4695 | 2 | 10 | 31 | |
| GSE46452 | NDUFA2 | 4695 | 0 | 27 | 32 | |
| GSE47630 | NDUFA2 | 4695 | 0 | 20 | 20 | |
| GSE54993 | NDUFA2 | 4695 | 9 | 1 | 60 | |
| GSE54994 | NDUFA2 | 4695 | 2 | 14 | 37 | |
| GSE60625 | NDUFA2 | 4695 | 0 | 0 | 11 | |
| GSE74703 | NDUFA2 | 4695 | 2 | 7 | 27 | |
| GSE74704 | NDUFA2 | 4695 | 3 | 5 | 12 | |
| TCGA | NDUFA2 | 4695 | 4 | 37 | 55 |
Total number of gains: 29; Total number of losses: 143; Total Number of normals: 316.
Somatic mutations of NDUFA2:
Generating mutation plots.
Highly correlated genes for NDUFA2:
Showing top 20/441 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NDUFA2 | ZNF436 | 0.765744 | 3 | 0 | 3 |
| NDUFA2 | FKBP8 | 0.759077 | 3 | 0 | 3 |
| NDUFA2 | TMEM38A | 0.749212 | 3 | 0 | 3 |
| NDUFA2 | FBXO10 | 0.730929 | 3 | 0 | 3 |
| NDUFA2 | GNGT2 | 0.725045 | 3 | 0 | 3 |
| NDUFA2 | SETMAR | 0.719786 | 4 | 0 | 4 |
| NDUFA2 | YBEY | 0.717581 | 3 | 0 | 3 |
| NDUFA2 | KLHL3 | 0.712865 | 3 | 0 | 3 |
| NDUFA2 | TOM1L1 | 0.712686 | 3 | 0 | 3 |
| NDUFA2 | NPRL2 | 0.712644 | 4 | 0 | 4 |
| NDUFA2 | KIAA0355 | 0.711396 | 3 | 0 | 3 |
| NDUFA2 | TMEM220 | 0.704949 | 3 | 0 | 3 |
| NDUFA2 | FAM98C | 0.70347 | 4 | 0 | 3 |
| NDUFA2 | HES4 | 0.70174 | 3 | 0 | 3 |
| NDUFA2 | LEPROT | 0.701371 | 3 | 0 | 3 |
| NDUFA2 | ACTR3C | 0.696918 | 3 | 0 | 3 |
| NDUFA2 | CDNF | 0.69028 | 4 | 0 | 3 |
| NDUFA2 | DVL1 | 0.689864 | 4 | 0 | 3 |
| NDUFA2 | CYLD | 0.689348 | 3 | 0 | 3 |
| NDUFA2 | NDUFA13 | 0.687281 | 7 | 0 | 5 |
For details and further investigation, click here
