| Full name: hydroxysteroid 17-beta dehydrogenase 4 | Alias Symbol: MFE-2|DBP|SDR8C1 | ||
| Type: protein-coding gene | Cytoband: 5q23.1 | ||
| Entrez ID: 3295 | HGNC ID: HGNC:5213 | Ensembl Gene: ENSG00000133835 | OMIM ID: 601860 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of HSD17B4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSD17B4 | 3295 | 201413_at | -0.6239 | 0.2418 | |
| GSE20347 | HSD17B4 | 3295 | 201413_at | -1.2593 | 0.0000 | |
| GSE23400 | HSD17B4 | 3295 | 201413_at | -0.7801 | 0.0000 | |
| GSE26886 | HSD17B4 | 3295 | 201413_at | -1.2493 | 0.0000 | |
| GSE29001 | HSD17B4 | 3295 | 201413_at | -0.8348 | 0.0001 | |
| GSE38129 | HSD17B4 | 3295 | 201413_at | -0.9909 | 0.0000 | |
| GSE45670 | HSD17B4 | 3295 | 201413_at | -0.4858 | 0.0047 | |
| GSE53622 | HSD17B4 | 3295 | 29883 | -0.8199 | 0.0000 | |
| GSE53624 | HSD17B4 | 3295 | 29883 | -0.9845 | 0.0000 | |
| GSE63941 | HSD17B4 | 3295 | 201413_at | -0.7080 | 0.0699 | |
| GSE77861 | HSD17B4 | 3295 | 201413_at | -1.3581 | 0.0007 | |
| GSE97050 | HSD17B4 | 3295 | A_23_P92954 | -0.0410 | 0.8851 | |
| SRP007169 | HSD17B4 | 3295 | RNAseq | -1.5137 | 0.0000 | |
| SRP008496 | HSD17B4 | 3295 | RNAseq | -1.4081 | 0.0000 | |
| SRP064894 | HSD17B4 | 3295 | RNAseq | -0.5359 | 0.0051 | |
| SRP133303 | HSD17B4 | 3295 | RNAseq | -0.6747 | 0.0013 | |
| SRP159526 | HSD17B4 | 3295 | RNAseq | -0.9492 | 0.0063 | |
| SRP193095 | HSD17B4 | 3295 | RNAseq | -1.1498 | 0.0000 | |
| SRP219564 | HSD17B4 | 3295 | RNAseq | -0.9149 | 0.0158 | |
| TCGA | HSD17B4 | 3295 | RNAseq | -0.1965 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by HSD17B4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSD17B4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSD17B4 | 3295 | 1 | 13 | 16 | |
| GSE20123 | HSD17B4 | 3295 | 1 | 13 | 16 | |
| GSE43470 | HSD17B4 | 3295 | 5 | 6 | 32 | |
| GSE46452 | HSD17B4 | 3295 | 0 | 27 | 32 | |
| GSE47630 | HSD17B4 | 3295 | 0 | 21 | 19 | |
| GSE54993 | HSD17B4 | 3295 | 9 | 1 | 60 | |
| GSE54994 | HSD17B4 | 3295 | 2 | 14 | 37 | |
| GSE60625 | HSD17B4 | 3295 | 0 | 0 | 11 | |
| GSE74703 | HSD17B4 | 3295 | 3 | 5 | 28 | |
| GSE74704 | HSD17B4 | 3295 | 1 | 7 | 12 | |
| TCGA | HSD17B4 | 3295 | 1 | 43 | 52 |
Total number of gains: 23; Total number of losses: 150; Total Number of normals: 315.
Somatic mutations of HSD17B4:
Generating mutation plots.
Highly correlated genes for HSD17B4:
Showing top 20/1600 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSD17B4 | SLC16A6 | 0.842505 | 11 | 0 | 11 |
| HSD17B4 | HPGD | 0.81211 | 10 | 0 | 10 |
| HSD17B4 | NAGK | 0.799284 | 11 | 0 | 11 |
| HSD17B4 | VSIG10L | 0.797552 | 6 | 0 | 6 |
| HSD17B4 | SMIM14 | 0.79246 | 6 | 0 | 6 |
| HSD17B4 | SFTA2 | 0.789331 | 4 | 0 | 4 |
| HSD17B4 | TP53I3 | 0.789009 | 11 | 0 | 11 |
| HSD17B4 | GPD1L | 0.787642 | 10 | 0 | 10 |
| HSD17B4 | RMND5B | 0.786553 | 11 | 0 | 11 |
| HSD17B4 | CCDC6 | 0.78543 | 10 | 0 | 10 |
| HSD17B4 | ENDOU | 0.784623 | 11 | 0 | 11 |
| HSD17B4 | CLINT1 | 0.784462 | 11 | 0 | 11 |
| HSD17B4 | CXCR2 | 0.784314 | 11 | 0 | 10 |
| HSD17B4 | BLNK | 0.779545 | 11 | 0 | 11 |
| HSD17B4 | SASH1 | 0.779389 | 11 | 0 | 11 |
| HSD17B4 | CLCA4 | 0.778849 | 10 | 0 | 10 |
| HSD17B4 | PRSS27 | 0.776696 | 6 | 0 | 6 |
| HSD17B4 | CYP2J2 | 0.776636 | 10 | 0 | 10 |
| HSD17B4 | SLURP1 | 0.776449 | 10 | 0 | 10 |
| HSD17B4 | ACAA1 | 0.775318 | 10 | 0 | 9 |
For details and further investigation, click here
