| Full name: amyloid beta precursor like protein 2 | Alias Symbol: APPH | ||
| Type: protein-coding gene | Cytoband: 11q24.3 | ||
| Entrez ID: 334 | HGNC ID: HGNC:598 | Ensembl Gene: ENSG00000084234 | OMIM ID: 104776 |
| Drug and gene relationship at DGIdb | |||
Expression of APLP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APLP2 | 334 | 208248_x_at | 0.0619 | 0.9204 | |
| GSE20347 | APLP2 | 334 | 208248_x_at | -0.1832 | 0.1810 | |
| GSE23400 | APLP2 | 334 | 208704_x_at | -0.0156 | 0.8716 | |
| GSE26886 | APLP2 | 334 | 208704_x_at | -0.7884 | 0.0161 | |
| GSE29001 | APLP2 | 334 | 208248_x_at | -0.0940 | 0.7652 | |
| GSE38129 | APLP2 | 334 | 208248_x_at | -0.2394 | 0.1520 | |
| GSE45670 | APLP2 | 334 | 208248_x_at | -0.1405 | 0.6292 | |
| GSE53622 | APLP2 | 334 | 22931 | 0.0655 | 0.3777 | |
| GSE53624 | APLP2 | 334 | 22931 | 0.1200 | 0.1198 | |
| GSE63941 | APLP2 | 334 | 208702_x_at | 0.5757 | 0.1962 | |
| GSE77861 | APLP2 | 334 | 208704_x_at | 0.6161 | 0.0445 | |
| GSE97050 | APLP2 | 334 | A_23_P202939 | -0.3069 | 0.3356 | |
| SRP007169 | APLP2 | 334 | RNAseq | 0.2999 | 0.5339 | |
| SRP008496 | APLP2 | 334 | RNAseq | 0.5304 | 0.0663 | |
| SRP064894 | APLP2 | 334 | RNAseq | 0.4991 | 0.0078 | |
| SRP133303 | APLP2 | 334 | RNAseq | 0.1262 | 0.4059 | |
| SRP159526 | APLP2 | 334 | RNAseq | 0.1410 | 0.6317 | |
| SRP193095 | APLP2 | 334 | RNAseq | -0.0923 | 0.5908 | |
| SRP219564 | APLP2 | 334 | RNAseq | 0.0069 | 0.9879 | |
| TCGA | APLP2 | 334 | RNAseq | -0.0775 | 0.0751 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by APLP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APLP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APLP2 | 334 | 0 | 13 | 17 | |
| GSE20123 | APLP2 | 334 | 0 | 13 | 17 | |
| GSE43470 | APLP2 | 334 | 2 | 7 | 34 | |
| GSE46452 | APLP2 | 334 | 3 | 26 | 30 | |
| GSE47630 | APLP2 | 334 | 2 | 19 | 19 | |
| GSE54993 | APLP2 | 334 | 10 | 0 | 60 | |
| GSE54994 | APLP2 | 334 | 5 | 19 | 29 | |
| GSE60625 | APLP2 | 334 | 0 | 3 | 8 | |
| GSE74703 | APLP2 | 334 | 1 | 5 | 30 | |
| GSE74704 | APLP2 | 334 | 0 | 9 | 11 | |
| TCGA | APLP2 | 334 | 5 | 50 | 41 |
Total number of gains: 28; Total number of losses: 164; Total Number of normals: 296.
Somatic mutations of APLP2:
Generating mutation plots.
Highly correlated genes for APLP2:
Showing top 20/320 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APLP2 | CA11 | 0.754596 | 3 | 0 | 3 |
| APLP2 | RASD2 | 0.742204 | 3 | 0 | 3 |
| APLP2 | AKT3 | 0.737209 | 4 | 0 | 4 |
| APLP2 | PRICKLE1 | 0.727853 | 3 | 0 | 3 |
| APLP2 | CORO6 | 0.723302 | 3 | 0 | 3 |
| APLP2 | USP22 | 0.719051 | 3 | 0 | 3 |
| APLP2 | CERS2 | 0.714789 | 3 | 0 | 3 |
| APLP2 | KLHL23 | 0.7132 | 4 | 0 | 3 |
| APLP2 | FGF12 | 0.708141 | 3 | 0 | 3 |
| APLP2 | ITIH5 | 0.706524 | 4 | 0 | 4 |
| APLP2 | ZNF385D | 0.697624 | 3 | 0 | 3 |
| APLP2 | NDN | 0.695733 | 3 | 0 | 3 |
| APLP2 | ZNF609 | 0.691679 | 3 | 0 | 3 |
| APLP2 | SIX5 | 0.691309 | 3 | 0 | 3 |
| APLP2 | HDAC6 | 0.688212 | 3 | 0 | 3 |
| APLP2 | RNF115 | 0.686568 | 4 | 0 | 4 |
| APLP2 | SYNM | 0.686258 | 4 | 0 | 3 |
| APLP2 | GADD45G | 0.685448 | 3 | 0 | 3 |
| APLP2 | SRC | 0.684985 | 4 | 0 | 4 |
| APLP2 | COPS7A | 0.682274 | 4 | 0 | 4 |
For details and further investigation, click here
