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Multi-Omics Database of ESCC

 

MRPL21

 

Full name: mitochondrial ribosomal protein L21 Alias Symbol: 
Type: protein-coding gene Cytoband: 11q13.3
Entrez ID: 219927 HGNC ID: HGNC:14479 Ensembl Gene: ENSG00000197345 OMIM ID: 611834
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of MRPL21:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MRPL21 219927 225315_at 1.0905 0.3760
GSE26886 MRPL21 219927 225315_at 1.5731 0.0002
GSE45670 MRPL21 219927 225315_at 0.3953 0.2493
GSE53622 MRPL21 219927 35919 1.2452 0.0000
GSE53624 MRPL21 219927 35919 1.1804 0.0000
GSE63941 MRPL21 219927 225315_at 1.6344 0.0144
GSE77861 MRPL21 219927 225315_at 0.6917 0.2052
GSE97050 MRPL21 219927 A_23_P115955 0.6349 0.2830
SRP007169 MRPL21 219927 RNAseq -0.3852 0.2246
SRP008496 MRPL21 219927 RNAseq -0.2545 0.1685
SRP064894 MRPL21 219927 RNAseq 0.8357 0.0238
SRP133303 MRPL21 219927 RNAseq 2.2808 0.0000
SRP159526 MRPL21 219927 RNAseq 2.4575 0.0000
SRP193095 MRPL21 219927 RNAseq 1.0756 0.0001
TCGA MRPL21 219927 RNAseq 0.3665 0.0013

Upregulated datasets: 7; Downregulated datasets: 0.  

 

Survival by MRPL21 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MRPL21:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MRPL21 219927 13 2 15
GSE20123 MRPL21 219927 13 2 15
GSE43470 MRPL21 219927 10 3 30
GSE46452 MRPL21 219927 30 2 27
GSE47630 MRPL21 219927 17 2 21
GSE54993 MRPL21 219927 1 16 53
GSE54994 MRPL21 219927 22 4 27
GSE60625 MRPL21 219927 0 3 8
GSE74703 MRPL21 219927 8 2 26
GSE74704 MRPL21 219927 9 0 11
TCGA MRPL21 219927 49 4 43

Total number of gains: 172; Total number of losses: 40; Total Number of normals: 276.  

 

Somatic mutations of MRPL21:

 

Generating mutation plots.

 

Highly correlated genes for MRPL21:

 

Showing top 20/1013 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MRPL21MAPK60.79042303
MRPL21FADD0.755185707
MRPL21CDK2AP20.754858404
MRPL21CERS20.753305303
MRPL21MLLT10.750671303
MRPL21USP30.74966303
MRPL21INO80B0.738802303
MRPL21S1PR50.731515303
MRPL21FAM168B0.723578303
MRPL21NBAS0.718518303
MRPL21BAD0.718265303
MRPL21EIF3D0.712944303
MRPL21EBNA1BP20.709247303
MRPL21CHST30.708585303
MRPL21C11orf240.707402606
MRPL21FXR10.705204505
MRPL21FBXO110.699514303
MRPL21BRAT10.698129505
MRPL21POPDC30.696817403
MRPL21FAM86C10.695912404

For details and further investigation, click here