| Full name: vacuolar protein sorting 45 homolog | Alias Symbol: h-vps45|H1 | ||
| Type: protein-coding gene | Cytoband: 1q21.2 | ||
| Entrez ID: 11311 | HGNC ID: HGNC:14579 | Ensembl Gene: ENSG00000136631 | OMIM ID: 610035 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of VPS45:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VPS45 | 11311 | 209268_at | -0.0194 | 0.9753 | |
| GSE20347 | VPS45 | 11311 | 209268_at | -0.2688 | 0.0178 | |
| GSE23400 | VPS45 | 11311 | 209268_at | 0.0870 | 0.2679 | |
| GSE26886 | VPS45 | 11311 | 209268_at | -0.2203 | 0.1625 | |
| GSE29001 | VPS45 | 11311 | 209268_at | -0.0879 | 0.7512 | |
| GSE38129 | VPS45 | 11311 | 209268_at | -0.2238 | 0.0180 | |
| GSE45670 | VPS45 | 11311 | 209268_at | -0.1221 | 0.3518 | |
| GSE53622 | VPS45 | 11311 | 58898 | 0.1472 | 0.0217 | |
| GSE53624 | VPS45 | 11311 | 58898 | -0.0137 | 0.8511 | |
| GSE63941 | VPS45 | 11311 | 209268_at | 0.0886 | 0.8218 | |
| GSE77861 | VPS45 | 11311 | 209268_at | -0.2078 | 0.2538 | |
| GSE97050 | VPS45 | 11311 | A_23_P23719 | -0.0303 | 0.9240 | |
| SRP007169 | VPS45 | 11311 | RNAseq | -0.4371 | 0.2211 | |
| SRP008496 | VPS45 | 11311 | RNAseq | -0.3965 | 0.1210 | |
| SRP064894 | VPS45 | 11311 | RNAseq | 0.0064 | 0.9564 | |
| SRP133303 | VPS45 | 11311 | RNAseq | 0.0381 | 0.8135 | |
| SRP159526 | VPS45 | 11311 | RNAseq | 0.1634 | 0.4937 | |
| SRP193095 | VPS45 | 11311 | RNAseq | -0.2239 | 0.0052 | |
| SRP219564 | VPS45 | 11311 | RNAseq | -0.0862 | 0.7634 | |
| TCGA | VPS45 | 11311 | RNAseq | -0.0161 | 0.7495 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by VPS45 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VPS45:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VPS45 | 11311 | 15 | 0 | 15 | |
| GSE20123 | VPS45 | 11311 | 15 | 0 | 15 | |
| GSE43470 | VPS45 | 11311 | 6 | 1 | 36 | |
| GSE46452 | VPS45 | 11311 | 2 | 1 | 56 | |
| GSE47630 | VPS45 | 11311 | 14 | 0 | 26 | |
| GSE54993 | VPS45 | 11311 | 0 | 3 | 67 | |
| GSE54994 | VPS45 | 11311 | 15 | 0 | 38 | |
| GSE60625 | VPS45 | 11311 | 0 | 0 | 11 | |
| GSE74703 | VPS45 | 11311 | 6 | 1 | 29 | |
| GSE74704 | VPS45 | 11311 | 7 | 0 | 13 | |
| TCGA | VPS45 | 11311 | 37 | 3 | 56 |
Total number of gains: 117; Total number of losses: 9; Total Number of normals: 362.
Somatic mutations of VPS45:
Generating mutation plots.
Highly correlated genes for VPS45:
Showing top 20/406 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VPS45 | PCNT | 0.777204 | 3 | 0 | 3 |
| VPS45 | STX6 | 0.759985 | 3 | 0 | 3 |
| VPS45 | MRFAP1 | 0.748436 | 3 | 0 | 3 |
| VPS45 | CDC37L1 | 0.733678 | 3 | 0 | 3 |
| VPS45 | CEP95 | 0.732796 | 3 | 0 | 3 |
| VPS45 | ZNF544 | 0.706003 | 3 | 0 | 3 |
| VPS45 | RALGAPB | 0.705983 | 3 | 0 | 3 |
| VPS45 | PAN3 | 0.699256 | 4 | 0 | 3 |
| VPS45 | ZCCHC14 | 0.698322 | 3 | 0 | 3 |
| VPS45 | TBC1D8 | 0.686071 | 3 | 0 | 3 |
| VPS45 | DCAF10 | 0.685518 | 4 | 0 | 4 |
| VPS45 | NFXL1 | 0.68167 | 3 | 0 | 3 |
| VPS45 | RRAGC | 0.681561 | 3 | 0 | 3 |
| VPS45 | TMEM167B | 0.679337 | 3 | 0 | 3 |
| VPS45 | MLKL | 0.676725 | 3 | 0 | 3 |
| VPS45 | PDZD11 | 0.675597 | 3 | 0 | 3 |
| VPS45 | ARFGAP2 | 0.673902 | 3 | 0 | 3 |
| VPS45 | CDC73 | 0.672926 | 3 | 0 | 3 |
| VPS45 | EIF3E | 0.671735 | 4 | 0 | 3 |
| VPS45 | EP400 | 0.669142 | 3 | 0 | 3 |
For details and further investigation, click here
