| Full name: vacuolar protein sorting 4 homolog A | Alias Symbol: VPS4|VPS4-1|FLJ22197|SKD2|SKD1|SKD1A | ||
| Type: protein-coding gene | Cytoband: 16q23.1 | ||
| Entrez ID: 27183 | HGNC ID: HGNC:13488 | Ensembl Gene: ENSG00000132612 | OMIM ID: 609982 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of VPS4A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VPS4A | 27183 | 217913_at | 0.1240 | 0.6291 | |
| GSE20347 | VPS4A | 27183 | 217913_at | -0.0612 | 0.6806 | |
| GSE23400 | VPS4A | 27183 | 217913_at | -0.1878 | 0.0002 | |
| GSE26886 | VPS4A | 27183 | 217913_at | 0.0445 | 0.8114 | |
| GSE29001 | VPS4A | 27183 | 217913_at | -0.4102 | 0.1001 | |
| GSE38129 | VPS4A | 27183 | 217913_at | -0.1192 | 0.2147 | |
| GSE45670 | VPS4A | 27183 | 217913_at | -0.1608 | 0.0748 | |
| GSE53622 | VPS4A | 27183 | 83624 | -0.3016 | 0.0000 | |
| GSE53624 | VPS4A | 27183 | 83624 | -0.1958 | 0.0000 | |
| GSE63941 | VPS4A | 27183 | 217913_at | -0.2158 | 0.6045 | |
| GSE77861 | VPS4A | 27183 | 217913_at | -0.0745 | 0.6763 | |
| GSE97050 | VPS4A | 27183 | A_23_P329772 | -0.1605 | 0.4610 | |
| SRP007169 | VPS4A | 27183 | RNAseq | -1.0701 | 0.0009 | |
| SRP008496 | VPS4A | 27183 | RNAseq | -1.1014 | 0.0001 | |
| SRP064894 | VPS4A | 27183 | RNAseq | -0.4230 | 0.0217 | |
| SRP133303 | VPS4A | 27183 | RNAseq | -0.0435 | 0.7507 | |
| SRP159526 | VPS4A | 27183 | RNAseq | 0.0901 | 0.6967 | |
| SRP193095 | VPS4A | 27183 | RNAseq | 0.0334 | 0.7378 | |
| SRP219564 | VPS4A | 27183 | RNAseq | -0.4880 | 0.0745 | |
| TCGA | VPS4A | 27183 | RNAseq | -0.0583 | 0.1987 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by VPS4A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VPS4A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VPS4A | 27183 | 8 | 1 | 21 | |
| GSE20123 | VPS4A | 27183 | 8 | 1 | 21 | |
| GSE43470 | VPS4A | 27183 | 2 | 7 | 34 | |
| GSE46452 | VPS4A | 27183 | 38 | 1 | 20 | |
| GSE47630 | VPS4A | 27183 | 11 | 8 | 21 | |
| GSE54993 | VPS4A | 27183 | 2 | 4 | 64 | |
| GSE54994 | VPS4A | 27183 | 8 | 10 | 35 | |
| GSE60625 | VPS4A | 27183 | 4 | 0 | 7 | |
| GSE74703 | VPS4A | 27183 | 2 | 4 | 30 | |
| GSE74704 | VPS4A | 27183 | 4 | 0 | 16 | |
| TCGA | VPS4A | 27183 | 29 | 12 | 55 |
Total number of gains: 116; Total number of losses: 48; Total Number of normals: 324.
Somatic mutations of VPS4A:
Generating mutation plots.
Highly correlated genes for VPS4A:
Showing top 20/321 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VPS4A | MED26 | 0.749377 | 3 | 0 | 3 |
| VPS4A | INTS9 | 0.740724 | 3 | 0 | 3 |
| VPS4A | RAD18 | 0.723677 | 3 | 0 | 3 |
| VPS4A | DCTN1 | 0.702634 | 3 | 0 | 3 |
| VPS4A | ZNF771 | 0.70157 | 3 | 0 | 3 |
| VPS4A | DMPK | 0.689031 | 3 | 0 | 3 |
| VPS4A | ANKS6 | 0.685904 | 3 | 0 | 3 |
| VPS4A | RAB7A | 0.684433 | 3 | 0 | 3 |
| VPS4A | LGI2 | 0.682118 | 3 | 0 | 3 |
| VPS4A | PALM | 0.677844 | 4 | 0 | 3 |
| VPS4A | ARAP1 | 0.677035 | 3 | 0 | 3 |
| VPS4A | E2F4 | 0.673929 | 4 | 0 | 4 |
| VPS4A | ADAD2 | 0.662933 | 4 | 0 | 4 |
| VPS4A | VPS18 | 0.662029 | 3 | 0 | 3 |
| VPS4A | ZNF174 | 0.658657 | 3 | 0 | 3 |
| VPS4A | INO80E | 0.658394 | 3 | 0 | 3 |
| VPS4A | PRKCSH | 0.655816 | 3 | 0 | 3 |
| VPS4A | EIF4G1 | 0.654598 | 3 | 0 | 3 |
| VPS4A | PLEKHM2 | 0.651302 | 6 | 0 | 4 |
| VPS4A | PIP4K2C | 0.650018 | 4 | 0 | 3 |
For details and further investigation, click here
