| Full name: VPS54 subunit of GARP complex | Alias Symbol: HCC8|PPP1R164 | ||
| Type: protein-coding gene | Cytoband: 2p15-p14 | ||
| Entrez ID: 51542 | HGNC ID: HGNC:18652 | Ensembl Gene: ENSG00000143952 | OMIM ID: 614633 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of VPS54:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VPS54 | 51542 | 218423_x_at | 0.1256 | 0.8023 | |
| GSE20347 | VPS54 | 51542 | 218423_x_at | 0.1497 | 0.3520 | |
| GSE23400 | VPS54 | 51542 | 218423_x_at | 0.2815 | 0.0000 | |
| GSE26886 | VPS54 | 51542 | 222627_at | -0.5536 | 0.0552 | |
| GSE29001 | VPS54 | 51542 | 218423_x_at | 0.2222 | 0.3816 | |
| GSE38129 | VPS54 | 51542 | 218423_x_at | 0.2901 | 0.0181 | |
| GSE45670 | VPS54 | 51542 | 218423_x_at | 0.0088 | 0.9583 | |
| GSE53622 | VPS54 | 51542 | 124243 | 0.0705 | 0.2582 | |
| GSE53624 | VPS54 | 51542 | 42892 | -0.0691 | 0.4039 | |
| GSE63941 | VPS54 | 51542 | 218423_x_at | 0.1364 | 0.7826 | |
| GSE77861 | VPS54 | 51542 | 218423_x_at | 0.3133 | 0.1346 | |
| GSE97050 | VPS54 | 51542 | A_23_P131737 | 0.1284 | 0.5918 | |
| SRP007169 | VPS54 | 51542 | RNAseq | -0.0368 | 0.9292 | |
| SRP008496 | VPS54 | 51542 | RNAseq | 0.0926 | 0.6934 | |
| SRP064894 | VPS54 | 51542 | RNAseq | -0.1016 | 0.4761 | |
| SRP133303 | VPS54 | 51542 | RNAseq | 0.1675 | 0.1924 | |
| SRP159526 | VPS54 | 51542 | RNAseq | 0.3621 | 0.0655 | |
| SRP193095 | VPS54 | 51542 | RNAseq | -0.1871 | 0.0428 | |
| SRP219564 | VPS54 | 51542 | RNAseq | 0.1073 | 0.7032 | |
| TCGA | VPS54 | 51542 | RNAseq | -0.0581 | 0.2339 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by VPS54 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VPS54:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VPS54 | 51542 | 12 | 0 | 18 | |
| GSE20123 | VPS54 | 51542 | 12 | 0 | 18 | |
| GSE43470 | VPS54 | 51542 | 7 | 0 | 36 | |
| GSE46452 | VPS54 | 51542 | 2 | 3 | 54 | |
| GSE47630 | VPS54 | 51542 | 8 | 0 | 32 | |
| GSE54993 | VPS54 | 51542 | 0 | 6 | 64 | |
| GSE54994 | VPS54 | 51542 | 12 | 0 | 41 | |
| GSE60625 | VPS54 | 51542 | 0 | 3 | 8 | |
| GSE74703 | VPS54 | 51542 | 7 | 0 | 29 | |
| GSE74704 | VPS54 | 51542 | 10 | 0 | 10 | |
| TCGA | VPS54 | 51542 | 36 | 2 | 58 |
Total number of gains: 106; Total number of losses: 14; Total Number of normals: 368.
Somatic mutations of VPS54:
Generating mutation plots.
Highly correlated genes for VPS54:
Showing top 20/420 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VPS54 | PGGT1B | 0.741525 | 3 | 0 | 3 |
| VPS54 | KIF20B | 0.674997 | 3 | 0 | 3 |
| VPS54 | RNF149 | 0.669811 | 3 | 0 | 3 |
| VPS54 | PANK1 | 0.665187 | 4 | 0 | 4 |
| VPS54 | ELMOD2 | 0.656703 | 4 | 0 | 3 |
| VPS54 | SLTM | 0.655554 | 3 | 0 | 3 |
| VPS54 | NCKAP1 | 0.644059 | 3 | 0 | 3 |
| VPS54 | MANSC1 | 0.643645 | 3 | 0 | 3 |
| VPS54 | C12orf66 | 0.641236 | 4 | 0 | 4 |
| VPS54 | UBE3A | 0.637986 | 3 | 0 | 3 |
| VPS54 | PIK3CB | 0.637418 | 4 | 0 | 3 |
| VPS54 | UBR3 | 0.63623 | 3 | 0 | 3 |
| VPS54 | ZNF140 | 0.63554 | 3 | 0 | 3 |
| VPS54 | ZNF398 | 0.633984 | 4 | 0 | 3 |
| VPS54 | CENPL | 0.631882 | 3 | 0 | 3 |
| VPS54 | CEP44 | 0.628813 | 3 | 0 | 3 |
| VPS54 | ZNF225 | 0.628576 | 3 | 0 | 3 |
| VPS54 | TRIM59 | 0.626638 | 6 | 0 | 4 |
| VPS54 | KIF21A | 0.625895 | 3 | 0 | 3 |
| VPS54 | SAP130 | 0.625201 | 8 | 0 | 5 |
For details and further investigation, click here
