TRIM59

 

Full name: tripartite motif containing 59 Alias Symbol: TSBF1|Mrf1|RNF104
Type: protein-coding gene Cytoband: 3q25.33
Entrez ID: 286827 HGNC ID: HGNC:30834 Ensembl Gene: ENSG00000213186 OMIM ID: 616148
Drug and gene relationship at DGIdb

 

Expression of TRIM59:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TRIM59 286827 227801_at 1.1358 0.0506
GSE26886 TRIM59 286827 227801_at -0.3638 0.2651
GSE45670 TRIM59 286827 227801_at 0.6747 0.0154
GSE53622 TRIM59 286827 125588 0.8442 0.0000
GSE53624 TRIM59 286827 125588 1.0704 0.0000
GSE63941 TRIM59 286827 227801_at 0.6399 0.7062
GSE77861 TRIM59 286827 227801_at 0.9231 0.0348
GSE97050 TRIM59 286827 A_32_P72341 0.3294 0.2433
SRP007169 TRIM59 286827 RNAseq 0.8698 0.0316
SRP008496 TRIM59 286827 RNAseq 1.0041 0.0001
SRP064894 TRIM59 286827 RNAseq 0.8381 0.0031
SRP133303 TRIM59 286827 RNAseq 1.3483 0.0000
SRP159526 TRIM59 286827 RNAseq 1.0443 0.0432
SRP193095 TRIM59 286827 RNAseq 0.7775 0.0000
SRP219564 TRIM59 286827 RNAseq 0.6367 0.2374
TCGA TRIM59 286827 RNAseq 0.8826 0.0000

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by TRIM59 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TRIM59:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TRIM59 286827 22 0 8
GSE20123 TRIM59 286827 22 0 8
GSE43470 TRIM59 286827 23 0 20
GSE46452 TRIM59 286827 18 2 39
GSE47630 TRIM59 286827 19 3 18
GSE54993 TRIM59 286827 1 11 58
GSE54994 TRIM59 286827 38 1 14
GSE60625 TRIM59 286827 0 6 5
GSE74703 TRIM59 286827 20 0 16
GSE74704 TRIM59 286827 14 0 6
TCGA TRIM59 286827 77 0 19

Total number of gains: 254; Total number of losses: 23; Total Number of normals: 211.  

 

Somatic mutations of TRIM59:

 

Generating mutation plots.

 

Highly correlated genes for TRIM59:

 

Showing top 20/1175 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TRIM59LRRC580.784567404
TRIM59DONSON0.779277404
TRIM59RASA20.774428303
TRIM59PSPC10.774383404
TRIM59DHTKD10.76929303
TRIM59FAM86C10.768946303
TRIM59BORA0.766416404
TRIM59RNF70.76639606
TRIM59CDCA20.763893404
TRIM59GGNBP20.763592303
TRIM59RACGAP10.760653404
TRIM59RNMT0.756572303
TRIM59FADD0.751581303
TRIM59ACTL6A0.750899606
TRIM59C1orf1310.747152606
TRIM59RBM150.746118303
TRIM59TUBA1B0.744562303
TRIM59FZD60.742706404
TRIM59ATR0.741575606
TRIM59ADO0.74104303

For details and further investigation, click here