| Full name: WASP family member 3 | Alias Symbol: WAVE3|SCAR3|KIAA0900 | ||
| Type: protein-coding gene | Cytoband: 13q12.13 | ||
| Entrez ID: 10810 | HGNC ID: HGNC:12734 | Ensembl Gene: ENSG00000132970 | OMIM ID: 605068 |
| Drug and gene relationship at DGIdb | |||
WASF3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04520 | Adherens junction | |
| hsa04666 | Fc gamma R-mediated phagocytosis | |
| hsa05231 | Choline metabolism in cancer |
Expression of WASF3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WASF3 | 10810 | 204042_at | -0.6139 | 0.7222 | |
| GSE20347 | WASF3 | 10810 | 204042_at | -0.2123 | 0.4111 | |
| GSE23400 | WASF3 | 10810 | 204042_at | -0.1271 | 0.1439 | |
| GSE26886 | WASF3 | 10810 | 204042_at | -0.1610 | 0.7228 | |
| GSE29001 | WASF3 | 10810 | 204042_at | 0.4718 | 0.4064 | |
| GSE38129 | WASF3 | 10810 | 204042_at | -0.6876 | 0.0419 | |
| GSE45670 | WASF3 | 10810 | 204042_at | -1.2865 | 0.0030 | |
| GSE53622 | WASF3 | 10810 | 75116 | -1.1626 | 0.0000 | |
| GSE53624 | WASF3 | 10810 | 75116 | -0.7529 | 0.0000 | |
| GSE63941 | WASF3 | 10810 | 204042_at | -2.6698 | 0.0854 | |
| GSE77861 | WASF3 | 10810 | 204042_at | -0.1088 | 0.6062 | |
| SRP007169 | WASF3 | 10810 | RNAseq | 0.8134 | 0.2200 | |
| SRP008496 | WASF3 | 10810 | RNAseq | 1.6430 | 0.0016 | |
| SRP064894 | WASF3 | 10810 | RNAseq | -0.3643 | 0.2471 | |
| SRP133303 | WASF3 | 10810 | RNAseq | -0.7317 | 0.0132 | |
| SRP159526 | WASF3 | 10810 | RNAseq | -0.0808 | 0.7788 | |
| SRP193095 | WASF3 | 10810 | RNAseq | 0.1590 | 0.4539 | |
| SRP219564 | WASF3 | 10810 | RNAseq | -0.0082 | 0.9888 | |
| TCGA | WASF3 | 10810 | RNAseq | -0.7035 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by WASF3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WASF3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WASF3 | 10810 | 1 | 13 | 16 | |
| GSE20123 | WASF3 | 10810 | 1 | 12 | 17 | |
| GSE43470 | WASF3 | 10810 | 2 | 12 | 29 | |
| GSE46452 | WASF3 | 10810 | 0 | 33 | 26 | |
| GSE47630 | WASF3 | 10810 | 3 | 26 | 11 | |
| GSE54993 | WASF3 | 10810 | 11 | 2 | 57 | |
| GSE54994 | WASF3 | 10810 | 1 | 13 | 39 | |
| GSE60625 | WASF3 | 10810 | 0 | 3 | 8 | |
| GSE74703 | WASF3 | 10810 | 2 | 9 | 25 | |
| GSE74704 | WASF3 | 10810 | 0 | 10 | 10 | |
| TCGA | WASF3 | 10810 | 6 | 43 | 47 |
Total number of gains: 27; Total number of losses: 176; Total Number of normals: 285.
Somatic mutations of WASF3:
Generating mutation plots.
Highly correlated genes for WASF3:
Showing top 20/374 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WASF3 | DIDO1 | 0.668734 | 4 | 0 | 4 |
| WASF3 | FLT1 | 0.631853 | 3 | 0 | 3 |
| WASF3 | PDE1A | 0.629678 | 6 | 0 | 4 |
| WASF3 | DLC1 | 0.626196 | 6 | 0 | 5 |
| WASF3 | TIMP2 | 0.626019 | 4 | 0 | 3 |
| WASF3 | CAND2 | 0.62502 | 5 | 0 | 5 |
| WASF3 | DCLK1 | 0.618374 | 5 | 0 | 5 |
| WASF3 | ARMCX1 | 0.618355 | 10 | 0 | 7 |
| WASF3 | RBM24 | 0.618233 | 5 | 0 | 5 |
| WASF3 | MAP3K3 | 0.618124 | 5 | 0 | 4 |
| WASF3 | TMEM47 | 0.614386 | 7 | 0 | 6 |
| WASF3 | GATA3 | 0.61179 | 3 | 0 | 3 |
| WASF3 | ITM2A | 0.610984 | 6 | 0 | 5 |
| WASF3 | NAP1L3 | 0.608882 | 8 | 0 | 6 |
| WASF3 | SYT11 | 0.60816 | 6 | 0 | 5 |
| WASF3 | CPQ | 0.606477 | 7 | 0 | 5 |
| WASF3 | THSD7A | 0.606435 | 5 | 0 | 4 |
| WASF3 | FAT4 | 0.606043 | 6 | 0 | 4 |
| WASF3 | TIMP3 | 0.604448 | 5 | 0 | 4 |
| WASF3 | GJA4 | 0.602331 | 3 | 0 | 3 |
For details and further investigation, click here
