| Full name: fms related tyrosine kinase 1 | Alias Symbol: VEGFR1 | ||
| Type: protein-coding gene | Cytoband: 13q12.3 | ||
| Entrez ID: 2321 | HGNC ID: HGNC:3763 | Ensembl Gene: ENSG00000102755 | OMIM ID: 165070 |
| Drug and gene relationship at DGIdb | |||
FLT1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway | |
| hsa04015 | Rap1 signaling pathway | |
| hsa04066 | HIF-1 signaling pathway | |
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion |
Expression of FLT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FLT1 | 2321 | 232809_s_at | -0.5429 | 0.3743 | |
| GSE20347 | FLT1 | 2321 | 222033_s_at | 0.0382 | 0.7636 | |
| GSE23400 | FLT1 | 2321 | 222033_s_at | 0.0550 | 0.3668 | |
| GSE26886 | FLT1 | 2321 | 232809_s_at | -0.4419 | 0.0382 | |
| GSE29001 | FLT1 | 2321 | 222033_s_at | -0.1420 | 0.5690 | |
| GSE38129 | FLT1 | 2321 | 222033_s_at | -0.1920 | 0.3517 | |
| GSE45670 | FLT1 | 2321 | 232809_s_at | -0.1328 | 0.5265 | |
| GSE53622 | FLT1 | 2321 | 63320 | 0.2121 | 0.0176 | |
| GSE53624 | FLT1 | 2321 | 63320 | 0.3884 | 0.0000 | |
| GSE63941 | FLT1 | 2321 | 232809_s_at | -0.0433 | 0.9204 | |
| GSE77861 | FLT1 | 2321 | 232809_s_at | -0.3329 | 0.2149 | |
| GSE97050 | FLT1 | A_21_P0000024 | 0.3520 | 0.1998 | ||
| SRP007169 | FLT1 | 2321 | RNAseq | 1.1961 | 0.0056 | |
| SRP008496 | FLT1 | 2321 | RNAseq | 1.4585 | 0.0000 | |
| SRP064894 | FLT1 | 2321 | RNAseq | 0.8926 | 0.0022 | |
| SRP133303 | FLT1 | 2321 | RNAseq | 0.5966 | 0.0000 | |
| SRP159526 | FLT1 | 2321 | RNAseq | 0.3674 | 0.3212 | |
| SRP193095 | FLT1 | 2321 | RNAseq | 0.7350 | 0.0000 | |
| SRP219564 | FLT1 | 2321 | RNAseq | 0.0811 | 0.8643 | |
| TCGA | FLT1 | 2321 | RNAseq | -0.2616 | 0.0022 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by FLT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FLT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FLT1 | 2321 | 1 | 13 | 16 | |
| GSE20123 | FLT1 | 2321 | 1 | 12 | 17 | |
| GSE43470 | FLT1 | 2321 | 2 | 12 | 29 | |
| GSE46452 | FLT1 | 2321 | 0 | 33 | 26 | |
| GSE47630 | FLT1 | 2321 | 3 | 26 | 11 | |
| GSE54993 | FLT1 | 2321 | 12 | 2 | 56 | |
| GSE54994 | FLT1 | 2321 | 2 | 13 | 38 | |
| GSE60625 | FLT1 | 2321 | 0 | 3 | 8 | |
| GSE74703 | FLT1 | 2321 | 2 | 9 | 25 | |
| GSE74704 | FLT1 | 2321 | 0 | 10 | 10 | |
| TCGA | FLT1 | 2321 | 8 | 38 | 50 |
Total number of gains: 31; Total number of losses: 171; Total Number of normals: 286.
Somatic mutations of FLT1:
Generating mutation plots.
Highly correlated genes for FLT1:
Showing top 20/159 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FLT1 | SCARF1 | 0.73058 | 3 | 0 | 3 |
| FLT1 | TIMP4 | 0.728809 | 3 | 0 | 3 |
| FLT1 | TGFB3 | 0.708851 | 3 | 0 | 3 |
| FLT1 | EFEMP1 | 0.705089 | 3 | 0 | 3 |
| FLT1 | FGF7 | 0.704883 | 4 | 0 | 3 |
| FLT1 | SRSF5 | 0.700623 | 3 | 0 | 3 |
| FLT1 | GNG11 | 0.695517 | 4 | 0 | 4 |
| FLT1 | DLL1 | 0.681877 | 3 | 0 | 3 |
| FLT1 | SOCS2 | 0.679269 | 3 | 0 | 3 |
| FLT1 | S1PR1 | 0.674257 | 4 | 0 | 3 |
| FLT1 | FRY | 0.671534 | 3 | 0 | 3 |
| FLT1 | PDE1A | 0.669456 | 4 | 0 | 4 |
| FLT1 | KLC1 | 0.661596 | 4 | 0 | 3 |
| FLT1 | TDRD3 | 0.661144 | 3 | 0 | 3 |
| FLT1 | CHN2 | 0.653755 | 4 | 0 | 3 |
| FLT1 | NLRP1 | 0.651056 | 3 | 0 | 3 |
| FLT1 | KCTD21 | 0.64245 | 3 | 0 | 3 |
| FLT1 | TNFRSF12A | 0.64215 | 3 | 0 | 3 |
| FLT1 | KCNJ8 | 0.640531 | 5 | 0 | 4 |
| FLT1 | THSD7A | 0.639514 | 5 | 0 | 4 |
For details and further investigation, click here
