| Full name: DNA topoisomerase II alpha | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 7153 | HGNC ID: HGNC:11989 | Ensembl Gene: ENSG00000131747 | OMIM ID: 126430 |
| Drug and gene relationship at DGIdb | |||
Expression of TOP2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TOP2A | 7153 | 201291_s_at | 1.8676 | 0.0399 | |
| GSE20347 | TOP2A | 7153 | 201292_at | 1.8891 | 0.0000 | |
| GSE23400 | TOP2A | 7153 | 201292_at | 2.2018 | 0.0000 | |
| GSE26886 | TOP2A | 7153 | 201291_s_at | 0.6556 | 0.1748 | |
| GSE29001 | TOP2A | 7153 | 201291_s_at | 1.8574 | 0.0001 | |
| GSE38129 | TOP2A | 7153 | 201292_at | 2.3649 | 0.0000 | |
| GSE45670 | TOP2A | 7153 | 201291_s_at | 2.0737 | 0.0000 | |
| GSE53622 | TOP2A | 7153 | 135622 | 2.2116 | 0.0000 | |
| GSE53624 | TOP2A | 7153 | 135622 | 2.2270 | 0.0000 | |
| GSE63941 | TOP2A | 7153 | 201291_s_at | 2.7972 | 0.0003 | |
| GSE77861 | TOP2A | 7153 | 201292_at | 1.4051 | 0.0036 | |
| GSE97050 | TOP2A | 7153 | A_23_P118834 | 2.2561 | 0.0804 | |
| SRP007169 | TOP2A | 7153 | RNAseq | 3.4837 | 0.0000 | |
| SRP008496 | TOP2A | 7153 | RNAseq | 2.6088 | 0.0000 | |
| SRP064894 | TOP2A | 7153 | RNAseq | 1.8396 | 0.0000 | |
| SRP133303 | TOP2A | 7153 | RNAseq | 1.8334 | 0.0000 | |
| SRP159526 | TOP2A | 7153 | RNAseq | 1.7332 | 0.0000 | |
| SRP193095 | TOP2A | 7153 | RNAseq | 1.1677 | 0.0000 | |
| SRP219564 | TOP2A | 7153 | RNAseq | 1.1387 | 0.0502 | |
| TCGA | TOP2A | 7153 | RNAseq | 0.9683 | 0.0000 |
Upregulated datasets: 16; Downregulated datasets: 0.
Survival by TOP2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TOP2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TOP2A | 7153 | 8 | 1 | 21 | |
| GSE20123 | TOP2A | 7153 | 8 | 1 | 21 | |
| GSE43470 | TOP2A | 7153 | 1 | 2 | 40 | |
| GSE46452 | TOP2A | 7153 | 34 | 0 | 25 | |
| GSE47630 | TOP2A | 7153 | 8 | 1 | 31 | |
| GSE54993 | TOP2A | 7153 | 3 | 4 | 63 | |
| GSE54994 | TOP2A | 7153 | 8 | 5 | 40 | |
| GSE60625 | TOP2A | 7153 | 4 | 0 | 7 | |
| GSE74703 | TOP2A | 7153 | 1 | 1 | 34 | |
| GSE74704 | TOP2A | 7153 | 5 | 1 | 14 | |
| TCGA | TOP2A | 7153 | 22 | 8 | 66 |
Total number of gains: 102; Total number of losses: 24; Total Number of normals: 362.
Somatic mutations of TOP2A:
Generating mutation plots.
Highly correlated genes for TOP2A:
Showing top 20/2011 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TOP2A | ASPM | 0.884595 | 13 | 0 | 13 |
| TOP2A | NEK2 | 0.883133 | 13 | 0 | 13 |
| TOP2A | UBE2C | 0.876429 | 13 | 0 | 13 |
| TOP2A | CENPF | 0.867096 | 13 | 0 | 13 |
| TOP2A | TPX2 | 0.864201 | 13 | 0 | 13 |
| TOP2A | NUF2 | 0.858565 | 9 | 0 | 9 |
| TOP2A | KIF14 | 0.856886 | 13 | 0 | 13 |
| TOP2A | CCNB2 | 0.856307 | 12 | 0 | 12 |
| TOP2A | BUB1 | 0.855606 | 11 | 0 | 11 |
| TOP2A | AURKA | 0.851696 | 13 | 0 | 13 |
| TOP2A | KIF20A | 0.850878 | 13 | 0 | 13 |
| TOP2A | BUB1B | 0.843526 | 10 | 0 | 10 |
| TOP2A | CEP55 | 0.842893 | 13 | 0 | 13 |
| TOP2A | BIRC5 | 0.840976 | 12 | 0 | 12 |
| TOP2A | TIMELESS | 0.83782 | 13 | 0 | 13 |
| TOP2A | NUSAP1 | 0.833033 | 13 | 0 | 13 |
| TOP2A | GINS1 | 0.831723 | 12 | 0 | 11 |
| TOP2A | RACGAP1 | 0.830293 | 11 | 0 | 11 |
| TOP2A | KNTC1 | 0.828616 | 12 | 0 | 12 |
| TOP2A | AURKB | 0.826867 | 13 | 0 | 13 |
For details and further investigation, click here
