| Full name: heat shock protein family D (Hsp60) member 1 | Alias Symbol: GroEL|HSP60 | ||
| Type: protein-coding gene | Cytoband: 2q33.1 | ||
| Entrez ID: 3329 | HGNC ID: HGNC:5261 | Ensembl Gene: ENSG00000144381 | OMIM ID: 118190 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
HSPD1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05152 | Tuberculosis |
Expression of HSPD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSPD1 | 3329 | 200807_s_at | 0.7058 | 0.0248 | |
| GSE20347 | HSPD1 | 3329 | 200807_s_at | 0.9806 | 0.0000 | |
| GSE23400 | HSPD1 | 3329 | 200807_s_at | 1.0336 | 0.0000 | |
| GSE26886 | HSPD1 | 3329 | 200807_s_at | 0.3989 | 0.0230 | |
| GSE29001 | HSPD1 | 3329 | 200807_s_at | 0.6478 | 0.0004 | |
| GSE38129 | HSPD1 | 3329 | 200807_s_at | 1.1074 | 0.0000 | |
| GSE45670 | HSPD1 | 3329 | 200807_s_at | 0.7208 | 0.0014 | |
| GSE53622 | HSPD1 | 3329 | 38615 | 0.8165 | 0.0000 | |
| GSE53624 | HSPD1 | 3329 | 38615 | 1.2234 | 0.0000 | |
| GSE63941 | HSPD1 | 3329 | 200807_s_at | 0.8791 | 0.0146 | |
| GSE77861 | HSPD1 | 3329 | 200807_s_at | 0.9400 | 0.0003 | |
| GSE97050 | HSPD1 | 3329 | A_32_P25273 | 0.3490 | 0.3835 | |
| SRP007169 | HSPD1 | 3329 | RNAseq | 0.9610 | 0.0300 | |
| SRP008496 | HSPD1 | 3329 | RNAseq | 0.9546 | 0.0037 | |
| SRP064894 | HSPD1 | 3329 | RNAseq | 0.5489 | 0.0058 | |
| SRP133303 | HSPD1 | 3329 | RNAseq | 1.0170 | 0.0000 | |
| SRP159526 | HSPD1 | 3329 | RNAseq | 0.9558 | 0.0001 | |
| SRP193095 | HSPD1 | 3329 | RNAseq | 0.6224 | 0.0001 | |
| SRP219564 | HSPD1 | 3329 | RNAseq | 0.0500 | 0.9278 | |
| TCGA | HSPD1 | 3329 | RNAseq | 0.1464 | 0.0010 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by HSPD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSPD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSPD1 | 3329 | 10 | 2 | 18 | |
| GSE20123 | HSPD1 | 3329 | 10 | 2 | 18 | |
| GSE43470 | HSPD1 | 3329 | 3 | 1 | 39 | |
| GSE46452 | HSPD1 | 3329 | 1 | 4 | 54 | |
| GSE47630 | HSPD1 | 3329 | 4 | 5 | 31 | |
| GSE54993 | HSPD1 | 3329 | 0 | 3 | 67 | |
| GSE54994 | HSPD1 | 3329 | 11 | 8 | 34 | |
| GSE60625 | HSPD1 | 3329 | 0 | 3 | 8 | |
| GSE74703 | HSPD1 | 3329 | 2 | 1 | 33 | |
| GSE74704 | HSPD1 | 3329 | 5 | 2 | 13 | |
| TCGA | HSPD1 | 3329 | 22 | 9 | 65 |
Total number of gains: 68; Total number of losses: 40; Total Number of normals: 380.
Somatic mutations of HSPD1:
Generating mutation plots.
Highly correlated genes for HSPD1:
Showing top 20/2071 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSPD1 | HSPE1 | 0.897622 | 12 | 0 | 12 |
| HSPD1 | PFDN2 | 0.781592 | 12 | 0 | 12 |
| HSPD1 | CCDC127 | 0.776186 | 3 | 0 | 3 |
| HSPD1 | FADS1 | 0.771096 | 3 | 0 | 3 |
| HSPD1 | MCM3 | 0.769573 | 11 | 0 | 10 |
| HSPD1 | CACYBP | 0.768905 | 12 | 0 | 12 |
| HSPD1 | PYCR2 | 0.76547 | 3 | 0 | 3 |
| HSPD1 | PTDSS1 | 0.763273 | 10 | 0 | 10 |
| HSPD1 | SLC39A3 | 0.759945 | 3 | 0 | 3 |
| HSPD1 | ATAD2 | 0.759453 | 11 | 0 | 11 |
| HSPD1 | SNRPE | 0.759079 | 12 | 0 | 12 |
| HSPD1 | CPSF6 | 0.756166 | 11 | 0 | 11 |
| HSPD1 | EBNA1BP2 | 0.753874 | 3 | 0 | 3 |
| HSPD1 | FZD6 | 0.753592 | 8 | 0 | 8 |
| HSPD1 | CCT4 | 0.751439 | 11 | 0 | 10 |
| HSPD1 | DNAJB11 | 0.751077 | 6 | 0 | 6 |
| HSPD1 | DSCC1 | 0.751068 | 10 | 0 | 10 |
| HSPD1 | CEP55 | 0.74836 | 11 | 0 | 10 |
| HSPD1 | U2SURP | 0.747293 | 10 | 0 | 8 |
| HSPD1 | ELOF1 | 0.746545 | 3 | 0 | 3 |
For details and further investigation, click here
