| Full name: WD repeat domain 46 | Alias Symbol: BING4|UTP7 | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 9277 | HGNC ID: HGNC:13923 | Ensembl Gene: ENSG00000227057 | OMIM ID: 611440 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of WDR46:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WDR46 | 9277 | 209196_at | 0.5757 | 0.2276 | |
| GSE20347 | WDR46 | 9277 | 209196_at | 0.0554 | 0.7391 | |
| GSE23400 | WDR46 | 9277 | 209196_at | 0.2055 | 0.0005 | |
| GSE26886 | WDR46 | 9277 | 209196_at | 0.2008 | 0.1970 | |
| GSE29001 | WDR46 | 9277 | 209196_at | 0.0986 | 0.7850 | |
| GSE38129 | WDR46 | 9277 | 209196_at | 0.2828 | 0.0738 | |
| GSE45670 | WDR46 | 9277 | 209196_at | 0.2352 | 0.0383 | |
| GSE53622 | WDR46 | 9277 | 22780 | 0.2981 | 0.0000 | |
| GSE53624 | WDR46 | 9277 | 32758 | 0.4282 | 0.0000 | |
| GSE63941 | WDR46 | 9277 | 209196_at | -0.2293 | 0.4775 | |
| GSE77861 | WDR46 | 9277 | 209196_at | 0.1768 | 0.2056 | |
| GSE97050 | WDR46 | 9277 | A_24_P389038 | 0.1587 | 0.6269 | |
| SRP007169 | WDR46 | 9277 | RNAseq | 0.2260 | 0.5597 | |
| SRP008496 | WDR46 | 9277 | RNAseq | 0.3357 | 0.2030 | |
| SRP064894 | WDR46 | 9277 | RNAseq | 0.6759 | 0.0037 | |
| SRP133303 | WDR46 | 9277 | RNAseq | 0.1869 | 0.0545 | |
| SRP159526 | WDR46 | 9277 | RNAseq | 0.3932 | 0.0365 | |
| SRP193095 | WDR46 | 9277 | RNAseq | 0.2097 | 0.0589 | |
| SRP219564 | WDR46 | 9277 | RNAseq | 0.4374 | 0.1311 | |
| TCGA | WDR46 | 9277 | RNAseq | 0.1353 | 0.0108 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by WDR46 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WDR46:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WDR46 | 9277 | 5 | 0 | 25 | |
| GSE20123 | WDR46 | 9277 | 5 | 0 | 25 | |
| GSE43470 | WDR46 | 9277 | 4 | 1 | 38 | |
| GSE46452 | WDR46 | 9277 | 2 | 9 | 48 | |
| GSE47630 | WDR46 | 9277 | 8 | 4 | 28 | |
| GSE54993 | WDR46 | 9277 | 3 | 1 | 66 | |
| GSE54994 | WDR46 | 9277 | 11 | 4 | 38 | |
| GSE60625 | WDR46 | 9277 | 1 | 0 | 10 | |
| GSE74703 | WDR46 | 9277 | 4 | 0 | 32 | |
| GSE74704 | WDR46 | 9277 | 2 | 0 | 18 | |
| TCGA | WDR46 | 9277 | 15 | 16 | 65 |
Total number of gains: 60; Total number of losses: 35; Total Number of normals: 393.
Somatic mutations of WDR46:
Generating mutation plots.
Highly correlated genes for WDR46:
Showing top 20/468 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WDR46 | BAX | 0.695034 | 7 | 0 | 6 |
| WDR46 | CAMKK2 | 0.689337 | 3 | 0 | 3 |
| WDR46 | STK11IP | 0.682433 | 3 | 0 | 3 |
| WDR46 | SPATA2 | 0.68089 | 3 | 0 | 3 |
| WDR46 | SURF6 | 0.676532 | 3 | 0 | 3 |
| WDR46 | ZNF668 | 0.673776 | 5 | 0 | 5 |
| WDR46 | ZNF184 | 0.662542 | 5 | 0 | 3 |
| WDR46 | EIF2S3 | 0.657954 | 4 | 0 | 3 |
| WDR46 | TM2D2 | 0.655211 | 3 | 0 | 3 |
| WDR46 | GTF2H4 | 0.651962 | 11 | 0 | 9 |
| WDR46 | MRPS12 | 0.651303 | 8 | 0 | 6 |
| WDR46 | TGIF2 | 0.649153 | 3 | 0 | 3 |
| WDR46 | ABCF1 | 0.642205 | 12 | 0 | 10 |
| WDR46 | RRP36 | 0.641988 | 8 | 0 | 5 |
| WDR46 | DHX9 | 0.639292 | 7 | 0 | 7 |
| WDR46 | YDJC | 0.638104 | 4 | 0 | 3 |
| WDR46 | WDR70 | 0.634061 | 5 | 0 | 3 |
| WDR46 | TANGO6 | 0.62328 | 3 | 0 | 3 |
| WDR46 | CD81 | 0.622767 | 3 | 0 | 3 |
| WDR46 | CCDC34 | 0.621791 | 4 | 0 | 3 |
For details and further investigation, click here
