STK11IP

 

Full name: serine/threonine kinase 11 interacting protein Alias Symbol: LIP1|KIAA1898|LKB1IP|STK11IP1
Type: protein-coding gene Cytoband: 2q35
Entrez ID: 114790 HGNC ID: HGNC:19184 Ensembl Gene: ENSG00000144589 OMIM ID: 607172
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of STK11IP:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 STK11IP 114790 225713_at 0.2329 0.6051
GSE26886 STK11IP 114790 225713_at -0.3070 0.0164
GSE45670 STK11IP 114790 225713_at 0.3489 0.0031
GSE53622 STK11IP 114790 15522 0.2711 0.0005
GSE53624 STK11IP 114790 15522 0.2279 0.0001
GSE63941 STK11IP 114790 225713_at 0.0920 0.7878
GSE77861 STK11IP 114790 225713_at 0.1636 0.1894
GSE97050 STK11IP 114790 A_23_P321320 0.0995 0.7900
SRP007169 STK11IP 114790 RNAseq 0.0393 0.9298
SRP008496 STK11IP 114790 RNAseq -0.1500 0.6282
SRP064894 STK11IP 114790 RNAseq 0.5896 0.0002
SRP133303 STK11IP 114790 RNAseq 0.1982 0.1856
SRP159526 STK11IP 114790 RNAseq 0.4429 0.2467
SRP193095 STK11IP 114790 RNAseq 0.1939 0.1156
SRP219564 STK11IP 114790 RNAseq 0.0618 0.7047
TCGA STK11IP 114790 RNAseq 0.0612 0.2930

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by STK11IP expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of STK11IP:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 STK11IP 114790 2 14 14
GSE20123 STK11IP 114790 2 13 15
GSE43470 STK11IP 114790 1 6 36
GSE46452 STK11IP 114790 0 5 54
GSE47630 STK11IP 114790 4 5 31
GSE54993 STK11IP 114790 1 2 67
GSE54994 STK11IP 114790 8 9 36
GSE60625 STK11IP 114790 0 3 8
GSE74703 STK11IP 114790 1 5 30
GSE74704 STK11IP 114790 2 7 11
TCGA STK11IP 114790 13 25 58

Total number of gains: 34; Total number of losses: 94; Total Number of normals: 360.  

 

Somatic mutations of STK11IP:

 

Generating mutation plots.

 

Highly correlated genes for STK11IP:

 

Showing top 20/242 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
STK11IPDYNLRB10.770578303
STK11IPCDK2AP20.769171303
STK11IPZNF2130.72874303
STK11IPAPH1A0.723701303
STK11IPPOP50.718767303
STK11IPRNF20.711181303
STK11IPELOF10.710118404
STK11IPMTF10.708494303
STK11IPFKBPL0.706872303
STK11IPPIP4K2C0.698955403
STK11IPCDK5RAP30.691262404
STK11IPNFYC0.684175303
STK11IPFOXJ30.683109303
STK11IPWDR460.682433303
STK11IPRUNDC10.682245303
STK11IPUNG0.680571403
STK11IPEPS15L10.67944303
STK11IPGPS10.678174303
STK11IPDOCK60.675775403
STK11IPGRB20.672525303

For details and further investigation, click here