| Full name: mitochondrial ribosomal protein S12 | Alias Symbol: RPS12|RPSM12 | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 6183 | HGNC ID: HGNC:10380 | Ensembl Gene: ENSG00000128626 | OMIM ID: 603021 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MRPS12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPS12 | 6183 | 204331_s_at | 0.7595 | 0.0284 | |
| GSE20347 | MRPS12 | 6183 | 204331_s_at | 0.7525 | 0.0025 | |
| GSE23400 | MRPS12 | 6183 | 204331_s_at | 0.9651 | 0.0000 | |
| GSE26886 | MRPS12 | 6183 | 204331_s_at | 0.7072 | 0.0043 | |
| GSE29001 | MRPS12 | 6183 | 204331_s_at | 1.2318 | 0.0409 | |
| GSE38129 | MRPS12 | 6183 | 204331_s_at | 1.0857 | 0.0001 | |
| GSE45670 | MRPS12 | 6183 | 204331_s_at | 0.7367 | 0.0002 | |
| GSE63941 | MRPS12 | 6183 | 204331_s_at | 0.5559 | 0.1117 | |
| GSE77861 | MRPS12 | 6183 | 204331_s_at | 1.0553 | 0.0073 | |
| GSE97050 | MRPS12 | 6183 | A_24_P569294 | 0.4178 | 0.2235 | |
| SRP007169 | MRPS12 | 6183 | RNAseq | 1.1600 | 0.0268 | |
| SRP008496 | MRPS12 | 6183 | RNAseq | 0.7591 | 0.0167 | |
| SRP064894 | MRPS12 | 6183 | RNAseq | 1.0910 | 0.0030 | |
| SRP133303 | MRPS12 | 6183 | RNAseq | 0.7940 | 0.0010 | |
| SRP159526 | MRPS12 | 6183 | RNAseq | 0.6719 | 0.0394 | |
| SRP193095 | MRPS12 | 6183 | RNAseq | 0.1505 | 0.3011 | |
| SRP219564 | MRPS12 | 6183 | RNAseq | 0.5364 | 0.1164 | |
| TCGA | MRPS12 | 6183 | RNAseq | 0.1864 | 0.0043 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by MRPS12 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of MRPS12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPS12 | 6183 | 7 | 4 | 19 | |
| GSE20123 | MRPS12 | 6183 | 7 | 3 | 20 | |
| GSE43470 | MRPS12 | 6183 | 4 | 10 | 29 | |
| GSE46452 | MRPS12 | 6183 | 47 | 2 | 10 | |
| GSE47630 | MRPS12 | 6183 | 9 | 5 | 26 | |
| GSE54993 | MRPS12 | 6183 | 17 | 3 | 50 | |
| GSE54994 | MRPS12 | 6183 | 6 | 9 | 38 | |
| GSE60625 | MRPS12 | 6183 | 9 | 0 | 2 | |
| GSE74703 | MRPS12 | 6183 | 4 | 6 | 26 | |
| GSE74704 | MRPS12 | 6183 | 7 | 1 | 12 | |
| TCGA | MRPS12 | 6183 | 14 | 16 | 66 |
Total number of gains: 131; Total number of losses: 59; Total Number of normals: 298.
Somatic mutations of MRPS12:
Generating mutation plots.
Highly correlated genes for MRPS12:
Showing top 20/1744 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPS12 | ABCF1 | 0.758735 | 8 | 0 | 8 |
| MRPS12 | UBE2T | 0.737552 | 6 | 0 | 6 |
| MRPS12 | HNRNPM | 0.736764 | 9 | 0 | 9 |
| MRPS12 | MTFR2 | 0.736561 | 4 | 0 | 3 |
| MRPS12 | FANCM | 0.735834 | 3 | 0 | 3 |
| MRPS12 | CDK4 | 0.733619 | 10 | 0 | 9 |
| MRPS12 | SRM | 0.727038 | 7 | 0 | 7 |
| MRPS12 | CKS1B | 0.725737 | 10 | 0 | 9 |
| MRPS12 | OGFOD2 | 0.722081 | 4 | 0 | 4 |
| MRPS12 | CLPTM1L | 0.72171 | 5 | 0 | 5 |
| MRPS12 | FUCA2 | 0.721669 | 4 | 0 | 4 |
| MRPS12 | RNASEH2A | 0.719886 | 10 | 0 | 10 |
| MRPS12 | TMEM138 | 0.717804 | 5 | 0 | 5 |
| MRPS12 | ILF2 | 0.71639 | 9 | 0 | 9 |
| MRPS12 | PRMT1 | 0.714615 | 10 | 0 | 8 |
| MRPS12 | CENPN | 0.71398 | 9 | 0 | 8 |
| MRPS12 | CDCA2 | 0.711551 | 5 | 0 | 4 |
| MRPS12 | TAGLN2 | 0.711385 | 9 | 0 | 8 |
| MRPS12 | SSR2 | 0.710377 | 9 | 0 | 9 |
| MRPS12 | AGTRAP | 0.708165 | 3 | 0 | 3 |
For details and further investigation, click here
