DHX9

 

Full name: DExH-box helicase 9 Alias Symbol: RHA
Type: protein-coding gene Cytoband: 1q25.3
Entrez ID: 1660 HGNC ID: HGNC:2750 Ensembl Gene: ENSG00000135829 OMIM ID: 603115
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of DHX9:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DHX9 1660 202420_s_at 0.5636 0.0289
GSE20347 DHX9 1660 202420_s_at 0.6603 0.0000
GSE23400 DHX9 1660 202420_s_at 0.6286 0.0000
GSE26886 DHX9 1660 202420_s_at 0.4337 0.0014
GSE29001 DHX9 1660 202420_s_at 0.9155 0.0011
GSE38129 DHX9 1660 202420_s_at 0.6648 0.0000
GSE45670 DHX9 1660 202420_s_at 0.4066 0.0008
GSE53622 DHX9 1660 142979 0.2365 0.0000
GSE53624 DHX9 1660 142979 0.3671 0.0000
GSE63941 DHX9 1660 212107_s_at 1.7254 0.0000
GSE77861 DHX9 1660 202420_s_at 0.5158 0.0048
GSE97050 DHX9 1660 A_24_P36847 0.1070 0.6233
SRP007169 DHX9 1660 RNAseq 0.7976 0.0084
SRP008496 DHX9 1660 RNAseq 0.7750 0.0001
SRP064894 DHX9 1660 RNAseq 0.2921 0.1441
SRP133303 DHX9 1660 RNAseq 0.5861 0.0000
SRP159526 DHX9 1660 RNAseq 0.7948 0.0004
SRP193095 DHX9 1660 RNAseq 0.4338 0.0000
SRP219564 DHX9 1660 RNAseq 0.4050 0.0708
TCGA DHX9 1660 RNAseq 0.1266 0.0020

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by DHX9 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DHX9:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DHX9 1660 12 0 18
GSE20123 DHX9 1660 12 0 18
GSE43470 DHX9 1660 7 1 35
GSE46452 DHX9 1660 3 1 55
GSE47630 DHX9 1660 14 0 26
GSE54993 DHX9 1660 0 6 64
GSE54994 DHX9 1660 15 0 38
GSE60625 DHX9 1660 0 0 11
GSE74703 DHX9 1660 7 1 28
GSE74704 DHX9 1660 5 0 15
TCGA DHX9 1660 40 3 53

Total number of gains: 115; Total number of losses: 12; Total Number of normals: 361.  

 

Somatic mutations of DHX9:

 

Generating mutation plots.

 

Highly correlated genes for DHX9:

 

Showing top 20/635 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DHX9CKS1B0.77013111011
DHX9IPO90.769099909
DHX9CCT30.76514410010
DHX9FAM24B0.755157303
DHX9BUB1B0.754018909
DHX9HOXC90.751699606
DHX9AURKB0.7363281009
DHX9RAD51AP10.73553610010
DHX9JAKMIP30.728476303
DHX9RFC40.72446812011
DHX9POC1A0.722692505
DHX9KIF4A0.72011711010
DHX9TNFAIP8L10.719412605
DHX9CDC200.71680511010
DHX9RFT10.716192403
DHX9CDC450.71602510010
DHX9PUS10.71460911010
DHX9YEATS20.7142991009
DHX9RNASEH2A0.71401111011
DHX9MAD2L10.71296310010

For details and further investigation, click here