BLCAP

 

Full name: BLCAP apoptosis inducing factor Alias Symbol: BC10
Type: protein-coding gene Cytoband: 20q11.23
Entrez ID: 10904 HGNC ID: HGNC:1055 Ensembl Gene: ENSG00000166619 OMIM ID: 613110
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of BLCAP:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 BLCAP 10904 201032_at 0.6661 0.1189
GSE20347 BLCAP 10904 201032_at 0.2874 0.0875
GSE23400 BLCAP 10904 201032_at 0.6343 0.0000
GSE26886 BLCAP 10904 201032_at -0.5225 0.0524
GSE29001 BLCAP 10904 201032_at 0.5230 0.1755
GSE38129 BLCAP 10904 201032_at 0.4461 0.0026
GSE45670 BLCAP 10904 201032_at 0.5603 0.0011
GSE53622 BLCAP 10904 37411 0.2515 0.0042
GSE53624 BLCAP 10904 4702 0.4720 0.0000
GSE63941 BLCAP 10904 201032_at 0.8896 0.1524
GSE77861 BLCAP 10904 201032_at 0.1234 0.4204
GSE97050 BLCAP 10904 A_33_P3300212 0.3813 0.3542
SRP007169 BLCAP 10904 RNAseq -0.0443 0.9095
SRP008496 BLCAP 10904 RNAseq 0.1352 0.5999
SRP064894 BLCAP 10904 RNAseq 0.5098 0.0295
SRP133303 BLCAP 10904 RNAseq 0.2066 0.2284
SRP159526 BLCAP 10904 RNAseq 0.0062 0.9698
SRP193095 BLCAP 10904 RNAseq 0.1520 0.2911
SRP219564 BLCAP 10904 RNAseq 0.2372 0.5319
TCGA BLCAP 10904 RNAseq 0.2700 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by BLCAP expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of BLCAP:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 BLCAP 10904 14 2 14
GSE20123 BLCAP 10904 14 2 14
GSE43470 BLCAP 10904 13 0 30
GSE46452 BLCAP 10904 29 0 30
GSE47630 BLCAP 10904 24 0 16
GSE54993 BLCAP 10904 0 17 53
GSE54994 BLCAP 10904 23 0 30
GSE60625 BLCAP 10904 0 0 11
GSE74703 BLCAP 10904 11 0 25
GSE74704 BLCAP 10904 10 1 9
TCGA BLCAP 10904 47 3 46

Total number of gains: 185; Total number of losses: 25; Total Number of normals: 278.  

 

Somatic mutations of BLCAP:

 

Generating mutation plots.

 

Highly correlated genes for BLCAP:

 

Showing top 20/706 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
BLCAPCCP1100.774624303
BLCAPMSTO10.759763303
BLCAPPOLR2K0.756963303
BLCAPALG10.748024303
BLCAPUSP360.739967303
BLCAPSLC7A6OS0.738134403
BLCAPHNRNPA10.737541404
BLCAPCCS0.734222404
BLCAPC12orf450.728416303
BLCAPPET1170.72772404
BLCAPXRN10.726797303
BLCAPMPHOSPH90.724473303
BLCAPMRPS280.719951404
BLCAPHAX10.717824303
BLCAPHSPA50.716075303
BLCAPPPHLN10.713574303
BLCAPSNX300.712284303
BLCAPSLC22A50.709773303
BLCAPPPP1R80.706446404
BLCAPPPP1R16A0.706283403

For details and further investigation, click here