| Full name: dolichyl-phosphate mannosyltransferase subunit 1, catalytic | Alias Symbol: MPDS|CDGIE | ||
| Type: protein-coding gene | Cytoband: 20q13.13 | ||
| Entrez ID: 8813 | HGNC ID: HGNC:3005 | Ensembl Gene: ENSG00000000419 | OMIM ID: 603503 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DPM1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DPM1 | 8813 | 202673_at | 0.3984 | 0.3862 | |
| GSE20347 | DPM1 | 8813 | 202673_at | 0.3754 | 0.0185 | |
| GSE23400 | DPM1 | 8813 | 202673_at | 0.6059 | 0.0000 | |
| GSE26886 | DPM1 | 8813 | 202673_at | 0.1370 | 0.5479 | |
| GSE29001 | DPM1 | 8813 | 202673_at | 0.5962 | 0.0186 | |
| GSE38129 | DPM1 | 8813 | 202673_at | 0.5114 | 0.0000 | |
| GSE45670 | DPM1 | 8813 | 202673_at | 0.3743 | 0.0120 | |
| GSE53622 | DPM1 | 8813 | 91854 | 0.3917 | 0.0000 | |
| GSE53624 | DPM1 | 8813 | 91854 | 0.3951 | 0.0000 | |
| GSE63941 | DPM1 | 8813 | 202673_at | 0.4292 | 0.2154 | |
| GSE77861 | DPM1 | 8813 | 202673_at | 0.2459 | 0.1695 | |
| GSE97050 | DPM1 | 8813 | A_23_P68472 | 0.4396 | 0.3058 | |
| SRP007169 | DPM1 | 8813 | RNAseq | -0.3377 | 0.2903 | |
| SRP008496 | DPM1 | 8813 | RNAseq | -0.1676 | 0.4737 | |
| SRP064894 | DPM1 | 8813 | RNAseq | 0.1100 | 0.5273 | |
| SRP133303 | DPM1 | 8813 | RNAseq | 0.5065 | 0.0001 | |
| SRP159526 | DPM1 | 8813 | RNAseq | 0.0372 | 0.8893 | |
| SRP193095 | DPM1 | 8813 | RNAseq | -0.1632 | 0.2476 | |
| SRP219564 | DPM1 | 8813 | RNAseq | 0.2533 | 0.2940 | |
| TCGA | DPM1 | 8813 | RNAseq | 0.1768 | 0.0007 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DPM1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DPM1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DPM1 | 8813 | 16 | 2 | 12 | |
| GSE20123 | DPM1 | 8813 | 16 | 2 | 12 | |
| GSE43470 | DPM1 | 8813 | 13 | 0 | 30 | |
| GSE46452 | DPM1 | 8813 | 29 | 0 | 30 | |
| GSE47630 | DPM1 | 8813 | 24 | 1 | 15 | |
| GSE54993 | DPM1 | 8813 | 0 | 17 | 53 | |
| GSE54994 | DPM1 | 8813 | 27 | 0 | 26 | |
| GSE60625 | DPM1 | 8813 | 0 | 0 | 11 | |
| GSE74703 | DPM1 | 8813 | 11 | 0 | 25 | |
| GSE74704 | DPM1 | 8813 | 12 | 0 | 8 | |
| TCGA | DPM1 | 8813 | 46 | 3 | 47 |
Total number of gains: 194; Total number of losses: 25; Total Number of normals: 269.
Somatic mutations of DPM1:
Generating mutation plots.
Highly correlated genes for DPM1:
Showing top 20/1275 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DPM1 | PPP1R8 | 0.758895 | 4 | 0 | 4 |
| DPM1 | PFDN4 | 0.752675 | 11 | 0 | 11 |
| DPM1 | PET117 | 0.748472 | 4 | 0 | 4 |
| DPM1 | CENPBD1 | 0.747845 | 3 | 0 | 3 |
| DPM1 | ALMS1 | 0.743832 | 3 | 0 | 3 |
| DPM1 | YTHDF2 | 0.734584 | 3 | 0 | 3 |
| DPM1 | CSE1L | 0.730486 | 13 | 0 | 12 |
| DPM1 | CEP70 | 0.724636 | 3 | 0 | 3 |
| DPM1 | CSTF1 | 0.722353 | 12 | 0 | 11 |
| DPM1 | FARS2 | 0.716447 | 3 | 0 | 3 |
| DPM1 | FAM169A | 0.712348 | 3 | 0 | 3 |
| DPM1 | NUDCD1 | 0.709559 | 5 | 0 | 5 |
| DPM1 | SOCS7 | 0.705617 | 3 | 0 | 3 |
| DPM1 | EIF3C | 0.704434 | 3 | 0 | 3 |
| DPM1 | DIDO1 | 0.703618 | 3 | 0 | 3 |
| DPM1 | MYH3 | 0.696979 | 3 | 0 | 3 |
| DPM1 | DYNC1LI2 | 0.694242 | 3 | 0 | 3 |
| DPM1 | GUSB | 0.685412 | 3 | 0 | 3 |
| DPM1 | STAU1 | 0.683694 | 10 | 0 | 9 |
| DPM1 | RSPRY1 | 0.683464 | 3 | 0 | 3 |
For details and further investigation, click here
