| Full name: plectin | Alias Symbol: PCN|PLTN | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 5339 | HGNC ID: HGNC:9069 | Ensembl Gene: ENSG00000178209 | OMIM ID: 601282 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PLEC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEC | 5339 | 216971_s_at | 1.0492 | 0.0481 | |
| GSE20347 | PLEC | 5339 | 201373_at | 0.2844 | 0.1524 | |
| GSE23400 | PLEC | 5339 | 201373_at | 0.2219 | 0.0020 | |
| GSE26886 | PLEC | 5339 | 201373_at | 0.5242 | 0.0004 | |
| GSE29001 | PLEC | 5339 | 201373_at | 0.1546 | 0.7418 | |
| GSE38129 | PLEC | 5339 | 201373_at | 0.2292 | 0.1193 | |
| GSE45670 | PLEC | 5339 | 201373_at | 0.2896 | 0.0810 | |
| GSE53622 | PLEC | 5339 | 13172 | 0.1531 | 0.0256 | |
| GSE53624 | PLEC | 5339 | 21127 | -0.3144 | 0.0002 | |
| GSE63941 | PLEC | 5339 | 201373_at | 1.1195 | 0.0261 | |
| GSE77861 | PLEC | 5339 | 201373_at | 0.6999 | 0.0993 | |
| GSE97050 | PLEC | 5339 | A_33_P3419098 | 0.2166 | 0.3997 | |
| SRP007169 | PLEC | 5339 | RNAseq | 1.6451 | 0.0002 | |
| SRP008496 | PLEC | 5339 | RNAseq | 1.5186 | 0.0000 | |
| SRP064894 | PLEC | 5339 | RNAseq | 0.5006 | 0.0396 | |
| SRP133303 | PLEC | 5339 | RNAseq | 0.8781 | 0.0006 | |
| SRP159526 | PLEC | 5339 | RNAseq | 0.2875 | 0.3574 | |
| SRP193095 | PLEC | 5339 | RNAseq | 0.9023 | 0.0000 | |
| SRP219564 | PLEC | 5339 | RNAseq | 0.6612 | 0.1547 | |
| TCGA | PLEC | 5339 | RNAseq | 0.1089 | 0.0464 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by PLEC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLEC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEC | 5339 | 17 | 1 | 12 | |
| GSE20123 | PLEC | 5339 | 17 | 1 | 12 | |
| GSE43470 | PLEC | 5339 | 16 | 2 | 25 | |
| GSE46452 | PLEC | 5339 | 27 | 0 | 32 | |
| GSE47630 | PLEC | 5339 | 23 | 1 | 16 | |
| GSE54993 | PLEC | 5339 | 0 | 25 | 45 | |
| GSE54994 | PLEC | 5339 | 39 | 1 | 13 | |
| GSE60625 | PLEC | 5339 | 3 | 4 | 4 | |
| GSE74703 | PLEC | 5339 | 14 | 1 | 21 | |
| GSE74704 | PLEC | 5339 | 10 | 0 | 10 | |
| TCGA | PLEC | 5339 | 64 | 2 | 30 |
Total number of gains: 230; Total number of losses: 38; Total Number of normals: 220.
Somatic mutations of PLEC:
Generating mutation plots.
Highly correlated genes for PLEC:
Showing top 20/521 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEC | ARHGAP22 | 0.762271 | 3 | 0 | 3 |
| PLEC | POU6F2-AS2 | 0.735743 | 3 | 0 | 3 |
| PLEC | DFFB | 0.733919 | 4 | 0 | 4 |
| PLEC | NPW | 0.716399 | 4 | 0 | 4 |
| PLEC | KCP | 0.715353 | 3 | 0 | 3 |
| PLEC | ATG16L1 | 0.713895 | 4 | 0 | 3 |
| PLEC | NSUN6 | 0.711516 | 3 | 0 | 3 |
| PLEC | HDAC8 | 0.710963 | 3 | 0 | 3 |
| PLEC | TMEM179 | 0.706543 | 3 | 0 | 3 |
| PLEC | C4orf48 | 0.700986 | 4 | 0 | 4 |
| PLEC | ZNF114 | 0.697863 | 4 | 0 | 3 |
| PLEC | TFAP2E | 0.697476 | 3 | 0 | 3 |
| PLEC | ZFAT | 0.694457 | 4 | 0 | 4 |
| PLEC | ZFPM1 | 0.692225 | 4 | 0 | 3 |
| PLEC | RELB | 0.692001 | 5 | 0 | 5 |
| PLEC | SPATA2L | 0.689844 | 4 | 0 | 4 |
| PLEC | BEND3 | 0.68828 | 4 | 0 | 3 |
| PLEC | SLC6A18 | 0.686326 | 3 | 0 | 3 |
| PLEC | RUNX1-IT1 | 0.68571 | 5 | 0 | 5 |
| PLEC | MFSD10 | 0.681994 | 5 | 0 | 4 |
For details and further investigation, click here
