| Full name: nucleophosmin/nucleoplasmin 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 10q24.32 | ||
| Entrez ID: 10360 | HGNC ID: HGNC:7931 | Ensembl Gene: ENSG00000107833 | OMIM ID: 606456 |
| Drug and gene relationship at DGIdb | |||
Expression of NPM3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NPM3 | 10360 | 205129_at | 1.0640 | 0.0471 | |
| GSE20347 | NPM3 | 10360 | 205129_at | 0.5437 | 0.0012 | |
| GSE23400 | NPM3 | 10360 | 205129_at | 0.6723 | 0.0000 | |
| GSE26886 | NPM3 | 10360 | 205129_at | 1.1285 | 0.0000 | |
| GSE29001 | NPM3 | 10360 | 205129_at | 0.2172 | 0.4216 | |
| GSE38129 | NPM3 | 10360 | 205129_at | 1.0412 | 0.0000 | |
| GSE45670 | NPM3 | 10360 | 205129_at | 0.6141 | 0.0082 | |
| GSE53622 | NPM3 | 10360 | 17397 | 0.6634 | 0.0000 | |
| GSE53624 | NPM3 | 10360 | 17397 | 0.9430 | 0.0000 | |
| GSE63941 | NPM3 | 10360 | 205129_at | 0.8030 | 0.0504 | |
| GSE77861 | NPM3 | 10360 | 205129_at | 0.4225 | 0.1798 | |
| GSE97050 | NPM3 | 10360 | A_23_P52298 | 0.4934 | 0.2237 | |
| SRP007169 | NPM3 | 10360 | RNAseq | 0.6008 | 0.2099 | |
| SRP008496 | NPM3 | 10360 | RNAseq | 0.8662 | 0.0232 | |
| SRP064894 | NPM3 | 10360 | RNAseq | 0.4893 | 0.0716 | |
| SRP133303 | NPM3 | 10360 | RNAseq | 0.8109 | 0.0000 | |
| SRP159526 | NPM3 | 10360 | RNAseq | 1.0352 | 0.0032 | |
| SRP193095 | NPM3 | 10360 | RNAseq | 0.7332 | 0.0001 | |
| SRP219564 | NPM3 | 10360 | RNAseq | 1.2204 | 0.0361 | |
| TCGA | NPM3 | 10360 | RNAseq | 0.7565 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by NPM3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NPM3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NPM3 | 10360 | 2 | 9 | 19 | |
| GSE20123 | NPM3 | 10360 | 2 | 8 | 20 | |
| GSE43470 | NPM3 | 10360 | 0 | 8 | 35 | |
| GSE46452 | NPM3 | 10360 | 0 | 11 | 48 | |
| GSE47630 | NPM3 | 10360 | 2 | 14 | 24 | |
| GSE54993 | NPM3 | 10360 | 8 | 0 | 62 | |
| GSE54994 | NPM3 | 10360 | 1 | 12 | 40 | |
| GSE60625 | NPM3 | 10360 | 0 | 0 | 11 | |
| GSE74703 | NPM3 | 10360 | 0 | 5 | 31 | |
| GSE74704 | NPM3 | 10360 | 1 | 4 | 15 | |
| TCGA | NPM3 | 10360 | 5 | 29 | 62 |
Total number of gains: 21; Total number of losses: 100; Total Number of normals: 367.
Somatic mutations of NPM3:
Generating mutation plots.
Highly correlated genes for NPM3:
Showing top 20/769 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NPM3 | CDCA5 | 0.752194 | 7 | 0 | 7 |
| NPM3 | BOP1 | 0.74989 | 3 | 0 | 3 |
| NPM3 | UBE2T | 0.726808 | 7 | 0 | 6 |
| NPM3 | LRWD1 | 0.712833 | 3 | 0 | 3 |
| NPM3 | TMEM102 | 0.710218 | 3 | 0 | 3 |
| NPM3 | NUBP2 | 0.707061 | 3 | 0 | 3 |
| NPM3 | CD276 | 0.69583 | 5 | 0 | 5 |
| NPM3 | CDC6 | 0.693471 | 9 | 0 | 8 |
| NPM3 | KNSTRN | 0.692566 | 7 | 0 | 6 |
| NPM3 | MTFP1 | 0.68649 | 6 | 0 | 6 |
| NPM3 | RUVBL1 | 0.682309 | 10 | 0 | 10 |
| NPM3 | SMPD4 | 0.681432 | 3 | 0 | 3 |
| NPM3 | NDC1 | 0.679566 | 10 | 0 | 10 |
| NPM3 | RANBP1 | 0.678949 | 11 | 0 | 10 |
| NPM3 | PRR15 | 0.676037 | 4 | 0 | 4 |
| NPM3 | GPR180 | 0.672584 | 5 | 0 | 5 |
| NPM3 | ZNF77 | 0.671037 | 4 | 0 | 3 |
| NPM3 | BCL2L12 | 0.669901 | 8 | 0 | 8 |
| NPM3 | ZWINT | 0.669086 | 10 | 0 | 8 |
| NPM3 | POC1A | 0.668985 | 5 | 0 | 5 |
For details and further investigation, click here
