| Full name: poly(ADP-ribose) polymerase family member 10 | Alias Symbol: FLJ14464 | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 84875 | HGNC ID: HGNC:25895 | Ensembl Gene: ENSG00000178685 | OMIM ID: 609564 |
| Drug and gene relationship at DGIdb | |||
Expression of PARP10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PARP10 | 84875 | 229350_x_at | 0.3085 | 0.7363 | |
| GSE26886 | PARP10 | 84875 | 229350_x_at | 0.6324 | 0.0049 | |
| GSE45670 | PARP10 | 84875 | 229350_x_at | 0.5632 | 0.0021 | |
| GSE53622 | PARP10 | 84875 | 76375 | 0.2602 | 0.0076 | |
| GSE53624 | PARP10 | 84875 | 76375 | 0.4970 | 0.0000 | |
| GSE63941 | PARP10 | 84875 | 229350_x_at | -0.8673 | 0.1021 | |
| GSE77861 | PARP10 | 84875 | 229350_x_at | 0.0282 | 0.8970 | |
| GSE97050 | PARP10 | 84875 | A_24_P340853 | 0.0798 | 0.7497 | |
| SRP007169 | PARP10 | 84875 | RNAseq | 0.7043 | 0.1528 | |
| SRP008496 | PARP10 | 84875 | RNAseq | 0.5926 | 0.0720 | |
| SRP064894 | PARP10 | 84875 | RNAseq | 1.1442 | 0.0000 | |
| SRP133303 | PARP10 | 84875 | RNAseq | 0.1185 | 0.5745 | |
| SRP159526 | PARP10 | 84875 | RNAseq | -0.2118 | 0.3534 | |
| SRP193095 | PARP10 | 84875 | RNAseq | 0.6436 | 0.0001 | |
| SRP219564 | PARP10 | 84875 | RNAseq | 1.1869 | 0.0401 | |
| TCGA | PARP10 | 84875 | RNAseq | 0.1746 | 0.0047 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by PARP10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PARP10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PARP10 | 84875 | 17 | 1 | 12 | |
| GSE20123 | PARP10 | 84875 | 17 | 1 | 12 | |
| GSE43470 | PARP10 | 84875 | 16 | 2 | 25 | |
| GSE46452 | PARP10 | 84875 | 27 | 0 | 32 | |
| GSE47630 | PARP10 | 84875 | 23 | 1 | 16 | |
| GSE54993 | PARP10 | 84875 | 0 | 25 | 45 | |
| GSE54994 | PARP10 | 84875 | 39 | 1 | 13 | |
| GSE60625 | PARP10 | 84875 | 3 | 4 | 4 | |
| GSE74703 | PARP10 | 84875 | 14 | 1 | 21 | |
| GSE74704 | PARP10 | 84875 | 10 | 0 | 10 | |
| TCGA | PARP10 | 84875 | 64 | 2 | 30 |
Total number of gains: 230; Total number of losses: 38; Total Number of normals: 220.
Somatic mutations of PARP10:
Generating mutation plots.
Highly correlated genes for PARP10:
Showing top 20/109 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PARP10 | CCDC142 | 0.7397 | 3 | 0 | 3 |
| PARP10 | SOHLH1 | 0.733377 | 3 | 0 | 3 |
| PARP10 | CDC42EP2 | 0.732496 | 3 | 0 | 3 |
| PARP10 | LRFN3 | 0.722235 | 3 | 0 | 3 |
| PARP10 | RALGDS | 0.718639 | 3 | 0 | 3 |
| PARP10 | RELB | 0.714201 | 3 | 0 | 3 |
| PARP10 | ZFAT | 0.714151 | 3 | 0 | 3 |
| PARP10 | LRCH4 | 0.711032 | 3 | 0 | 3 |
| PARP10 | BATF2 | 0.706657 | 5 | 0 | 5 |
| PARP10 | PNMA6A | 0.70356 | 3 | 0 | 3 |
| PARP10 | SHARPIN | 0.703324 | 6 | 0 | 6 |
| PARP10 | KIFC2 | 0.702335 | 3 | 0 | 3 |
| PARP10 | ZNF777 | 0.697288 | 3 | 0 | 3 |
| PARP10 | ARHGEF1 | 0.68988 | 4 | 0 | 4 |
| PARP10 | CCNJL | 0.681206 | 4 | 0 | 3 |
| PARP10 | C19orf12 | 0.68039 | 3 | 0 | 3 |
| PARP10 | ATP8B3 | 0.675382 | 3 | 0 | 3 |
| PARP10 | PPP1R13B | 0.674591 | 3 | 0 | 3 |
| PARP10 | FBLN7 | 0.672339 | 4 | 0 | 3 |
| PARP10 | MX2 | 0.670358 | 6 | 0 | 5 |
For details and further investigation, click here
