CHEK2

 

Full name: checkpoint kinase 2 Alias Symbol: CDS1|CHK2|HuCds1|PP1425|bA444G7
Type: protein-coding gene Cytoband: 22q12.1
Entrez ID: 11200 HGNC ID: HGNC:16627 Ensembl Gene: ENSG00000183765 OMIM ID: 604373
Related drugs: AZD-7762, CHEMBL1236539, CHEMBL179583, ISOGRANULATIMIDE, OLAPARIB, PF-00477736, PREXASERTIB, XL-844... [more]
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

CHEK2 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa05166HTLV-I infection

 

Expression of CHEK2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CHEK2 11200 210416_s_at 0.8316 0.0793
GSE20347 CHEK2 11200 210416_s_at 0.9583 0.0000
GSE23400 CHEK2 11200 210416_s_at 0.4773 0.0000
GSE26886 CHEK2 11200 210416_s_at 0.2960 0.1273
GSE29001 CHEK2 11200 210416_s_at 0.7977 0.0006
GSE38129 CHEK2 11200 210416_s_at 1.0876 0.0000
GSE45670 CHEK2 11200 210416_s_at 0.9393 0.0000
GSE53622 CHEK2 11200 8948 0.7900 0.0000
GSE53624 CHEK2 11200 25756 1.0398 0.0000
GSE63941 CHEK2 11200 210416_s_at 0.4887 0.4498
GSE77861 CHEK2 11200 210416_s_at 0.6727 0.0495
GSE97050 CHEK2 11200 A_33_P3386760 0.6238 0.1657
SRP007169 CHEK2 11200 RNAseq 1.0031 0.0128
SRP008496 CHEK2 11200 RNAseq 0.7847 0.0148
SRP064894 CHEK2 11200 RNAseq 1.0226 0.0000
SRP133303 CHEK2 11200 RNAseq 0.6399 0.0069
SRP159526 CHEK2 11200 RNAseq 1.1792 0.0000
SRP193095 CHEK2 11200 RNAseq 0.6225 0.0000
SRP219564 CHEK2 11200 RNAseq 1.0269 0.0036
TCGA CHEK2 11200 RNAseq 0.8624 0.0000

Upregulated datasets: 6; Downregulated datasets: 0.  

 

Survival by CHEK2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CHEK2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CHEK2 11200 3 3 24
GSE20123 CHEK2 11200 3 2 25
GSE43470 CHEK2 11200 3 6 34
GSE46452 CHEK2 11200 31 1 27
GSE47630 CHEK2 11200 8 5 27
GSE54993 CHEK2 11200 3 6 61
GSE54994 CHEK2 11200 11 8 34
GSE60625 CHEK2 11200 5 0 6
GSE74703 CHEK2 11200 3 5 28
GSE74704 CHEK2 11200 0 1 19
TCGA CHEK2 11200 27 15 54

Total number of gains: 97; Total number of losses: 52; Total Number of normals: 339.  

 

Somatic mutations of CHEK2:

 

Generating mutation plots.

 

Highly correlated genes for CHEK2:

 

Showing top 20/845 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CHEK2MCM20.74873411010
CHEK2UBE2C0.74186710010
CHEK2DNMT10.722631009
CHEK2CDCA80.7203411010
CHEK2LMNB20.7173581009
CHEK2IPO90.716464707
CHEK2LAMTOR40.710944505
CHEK2LRRC450.710196404
CHEK2BCR0.706298303
CHEK2CDCA20.706102404
CHEK2HJURP0.70478811010
CHEK2NUSAP10.7028771009
CHEK2CEP550.70260711010
CHEK2KIF4A0.7013412011
CHEK2UMPS0.700368807
CHEK2FOXM10.69956212010
CHEK2CDC200.69926611010
CHEK2PRR150.696251404
CHEK2DLGAP50.6926611010
CHEK2KIF18B0.6924881009

For details and further investigation, click here