| Full name: SH2 domain containing 3C | Alias Symbol: NSP3 | ||
| Type: protein-coding gene | Cytoband: 9q34.11 | ||
| Entrez ID: 10044 | HGNC ID: HGNC:16884 | Ensembl Gene: ENSG00000095370 | OMIM ID: 604722 |
| Drug and gene relationship at DGIdb | |||
Expression of SH2D3C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SH2D3C | 10044 | 226673_at | 0.0685 | 0.8087 | |
| GSE20347 | SH2D3C | 10044 | 215639_at | -0.0335 | 0.7469 | |
| GSE23400 | SH2D3C | 10044 | 215639_at | -0.0830 | 0.0281 | |
| GSE26886 | SH2D3C | 10044 | 226673_at | -0.0766 | 0.7231 | |
| GSE29001 | SH2D3C | 10044 | 215639_at | -0.0423 | 0.8000 | |
| GSE38129 | SH2D3C | 10044 | 215639_at | -0.0599 | 0.3954 | |
| GSE45670 | SH2D3C | 10044 | 226673_at | -0.0020 | 0.9937 | |
| GSE53622 | SH2D3C | 10044 | 37901 | -0.3056 | 0.0400 | |
| GSE53624 | SH2D3C | 10044 | 37901 | -0.1619 | 0.1733 | |
| GSE63941 | SH2D3C | 10044 | 226673_at | 0.0965 | 0.6395 | |
| GSE77861 | SH2D3C | 10044 | 226673_at | 0.0469 | 0.7926 | |
| GSE97050 | SH2D3C | 10044 | A_33_P3293918 | 0.4843 | 0.1716 | |
| SRP007169 | SH2D3C | 10044 | RNAseq | 1.9896 | 0.0024 | |
| SRP064894 | SH2D3C | 10044 | RNAseq | 0.7673 | 0.0051 | |
| SRP133303 | SH2D3C | 10044 | RNAseq | -0.3142 | 0.1711 | |
| SRP159526 | SH2D3C | 10044 | RNAseq | -0.1129 | 0.7355 | |
| SRP193095 | SH2D3C | 10044 | RNAseq | 0.5735 | 0.0047 | |
| SRP219564 | SH2D3C | 10044 | RNAseq | 0.2383 | 0.6486 | |
| TCGA | SH2D3C | 10044 | RNAseq | -0.2398 | 0.0206 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SH2D3C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SH2D3C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SH2D3C | 10044 | 6 | 9 | 15 | |
| GSE20123 | SH2D3C | 10044 | 6 | 9 | 15 | |
| GSE43470 | SH2D3C | 10044 | 5 | 6 | 32 | |
| GSE46452 | SH2D3C | 10044 | 6 | 13 | 40 | |
| GSE47630 | SH2D3C | 10044 | 4 | 15 | 21 | |
| GSE54993 | SH2D3C | 10044 | 3 | 3 | 64 | |
| GSE54994 | SH2D3C | 10044 | 11 | 8 | 34 | |
| GSE60625 | SH2D3C | 10044 | 0 | 0 | 11 | |
| GSE74703 | SH2D3C | 10044 | 5 | 4 | 27 | |
| GSE74704 | SH2D3C | 10044 | 3 | 7 | 10 | |
| TCGA | SH2D3C | 10044 | 27 | 25 | 44 |
Total number of gains: 76; Total number of losses: 99; Total Number of normals: 313.
Somatic mutations of SH2D3C:
Generating mutation plots.
Highly correlated genes for SH2D3C:
Showing top 20/734 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SH2D3C | POLR3D | 0.767713 | 3 | 0 | 3 |
| SH2D3C | ZNF343 | 0.763742 | 3 | 0 | 3 |
| SH2D3C | CHML | 0.761769 | 3 | 0 | 3 |
| SH2D3C | GIMAP5 | 0.750353 | 3 | 0 | 3 |
| SH2D3C | RGS18 | 0.741623 | 6 | 0 | 6 |
| SH2D3C | C1orf68 | 0.740811 | 3 | 0 | 3 |
| SH2D3C | RSBN1L | 0.739887 | 3 | 0 | 3 |
| SH2D3C | IFNA21 | 0.730672 | 4 | 0 | 4 |
| SH2D3C | GAD2 | 0.725527 | 4 | 0 | 4 |
| SH2D3C | MBTPS2 | 0.718753 | 5 | 0 | 5 |
| SH2D3C | STAC | 0.716392 | 3 | 0 | 3 |
| SH2D3C | GIT1 | 0.715325 | 3 | 0 | 3 |
| SH2D3C | ART1 | 0.713239 | 4 | 0 | 4 |
| SH2D3C | PHLDB1 | 0.712372 | 5 | 0 | 5 |
| SH2D3C | STAT2 | 0.709716 | 4 | 0 | 4 |
| SH2D3C | C19orf54 | 0.708727 | 3 | 0 | 3 |
| SH2D3C | ZYX | 0.708435 | 3 | 0 | 3 |
| SH2D3C | GIMAP1 | 0.704448 | 6 | 0 | 6 |
| SH2D3C | SPI1 | 0.703632 | 4 | 0 | 4 |
| SH2D3C | ESRRG | 0.701861 | 3 | 0 | 3 |
For details and further investigation, click here
