| Full name: transglutaminase 3 | Alias Symbol: TGE | ||
| Type: protein-coding gene | Cytoband: 20p13 | ||
| Entrez ID: 7053 | HGNC ID: HGNC:11779 | Ensembl Gene: ENSG00000125780 | OMIM ID: 600238 |
| Drug and gene relationship at DGIdb | |||
Expression of TGM3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TGM3 | 7053 | 206004_at | -4.4445 | 0.0841 | |
| GSE20347 | TGM3 | 7053 | 206004_at | -5.4205 | 0.0000 | |
| GSE23400 | TGM3 | 7053 | 206004_at | -4.0880 | 0.0000 | |
| GSE26886 | TGM3 | 7053 | 206004_at | -7.8108 | 0.0000 | |
| GSE29001 | TGM3 | 7053 | 206004_at | -5.6399 | 0.0000 | |
| GSE38129 | TGM3 | 7053 | 206004_at | -4.1237 | 0.0000 | |
| GSE45670 | TGM3 | 7053 | 206004_at | -1.9579 | 0.0348 | |
| GSE53622 | TGM3 | 7053 | 24794 | -4.2062 | 0.0000 | |
| GSE53624 | TGM3 | 7053 | 24794 | -4.7089 | 0.0000 | |
| GSE63941 | TGM3 | 7053 | 206004_at | 0.3019 | 0.2094 | |
| GSE77861 | TGM3 | 7053 | 206004_at | -2.9807 | 0.0541 | |
| GSE97050 | TGM3 | 7053 | A_23_P57118 | -3.4673 | 0.0828 | |
| SRP007169 | TGM3 | 7053 | RNAseq | -9.5923 | 0.0000 | |
| SRP008496 | TGM3 | 7053 | RNAseq | -5.9289 | 0.0000 | |
| SRP064894 | TGM3 | 7053 | RNAseq | -5.3946 | 0.0000 | |
| SRP133303 | TGM3 | 7053 | RNAseq | -7.2060 | 0.0000 | |
| SRP159526 | TGM3 | 7053 | RNAseq | -5.2745 | 0.0000 | |
| SRP219564 | TGM3 | 7053 | RNAseq | -5.9913 | 0.0001 | |
| TCGA | TGM3 | 7053 | RNAseq | -0.1413 | 0.8135 |
Upregulated datasets: 0; Downregulated datasets: 14.
Survival by TGM3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TGM3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TGM3 | 7053 | 12 | 3 | 15 | |
| GSE20123 | TGM3 | 7053 | 13 | 3 | 14 | |
| GSE43470 | TGM3 | 7053 | 11 | 1 | 31 | |
| GSE46452 | TGM3 | 7053 | 26 | 1 | 32 | |
| GSE47630 | TGM3 | 7053 | 18 | 4 | 18 | |
| GSE54993 | TGM3 | 7053 | 2 | 14 | 54 | |
| GSE54994 | TGM3 | 7053 | 24 | 2 | 27 | |
| GSE60625 | TGM3 | 7053 | 0 | 0 | 11 | |
| GSE74703 | TGM3 | 7053 | 10 | 1 | 25 | |
| GSE74704 | TGM3 | 7053 | 8 | 1 | 11 | |
| TCGA | TGM3 | 7053 | 40 | 11 | 45 |
Total number of gains: 164; Total number of losses: 41; Total Number of normals: 283.
Somatic mutations of TGM3:
Generating mutation plots.
Highly correlated genes for TGM3:
Showing top 20/1503 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TGM3 | CYSRT1 | 0.927302 | 6 | 0 | 6 |
| TGM3 | CRNN | 0.916962 | 12 | 0 | 12 |
| TGM3 | SLURP1 | 0.911733 | 12 | 0 | 12 |
| TGM3 | TMPRSS11B | 0.910449 | 8 | 0 | 8 |
| TGM3 | SCEL | 0.907193 | 12 | 0 | 12 |
| TGM3 | VSIG10L | 0.901348 | 7 | 0 | 7 |
| TGM3 | CRISP3 | 0.890325 | 11 | 0 | 11 |
| TGM3 | MAL | 0.887538 | 12 | 0 | 12 |
| TGM3 | CLCA4 | 0.883294 | 12 | 0 | 12 |
| TGM3 | CNFN | 0.879688 | 8 | 0 | 8 |
| TGM3 | KLK13 | 0.878032 | 12 | 0 | 12 |
| TGM3 | PRSS27 | 0.876851 | 8 | 0 | 8 |
| TGM3 | IL36A | 0.875864 | 11 | 0 | 11 |
| TGM3 | SPINK7 | 0.87408 | 9 | 0 | 9 |
| TGM3 | CLIC3 | 0.873033 | 10 | 0 | 10 |
| TGM3 | TMPRSS11E | 0.872653 | 12 | 0 | 11 |
| TGM3 | ECM1 | 0.871324 | 12 | 0 | 12 |
| TGM3 | NCCRP1 | 0.871222 | 4 | 0 | 4 |
| TGM3 | LYNX1 | 0.869835 | 8 | 0 | 8 |
| TGM3 | SPRR3 | 0.865416 | 13 | 0 | 13 |
For details and further investigation, click here
