| Full name: symplekin | Alias Symbol: SYM|SPK | ||
| Type: protein-coding gene | Cytoband: 19q13.32 | ||
| Entrez ID: 8189 | HGNC ID: HGNC:22935 | Ensembl Gene: ENSG00000125755 | OMIM ID: 602388 |
| Drug and gene relationship at DGIdb | |||
Expression of SYMPK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SYMPK | 8189 | 1554595_at | 0.3373 | 0.6387 | |
| GSE20347 | SYMPK | 8189 | 202339_at | 0.1257 | 0.0865 | |
| GSE23400 | SYMPK | 8189 | 32402_s_at | 0.2502 | 0.0000 | |
| GSE26886 | SYMPK | 8189 | 1554595_at | -0.8337 | 0.0024 | |
| GSE29001 | SYMPK | 8189 | 32402_s_at | -0.0331 | 0.8788 | |
| GSE38129 | SYMPK | 8189 | 202339_at | 0.2394 | 0.0701 | |
| GSE45670 | SYMPK | 8189 | 1554595_at | -0.0234 | 0.8843 | |
| GSE53622 | SYMPK | 8189 | 39449 | 0.2583 | 0.0000 | |
| GSE53624 | SYMPK | 8189 | 39449 | 0.6544 | 0.0000 | |
| GSE63941 | SYMPK | 8189 | 1554595_at | 0.5714 | 0.0354 | |
| GSE77861 | SYMPK | 8189 | 1554595_at | 0.1040 | 0.6215 | |
| GSE97050 | SYMPK | 8189 | A_33_P3327702 | 0.2051 | 0.3061 | |
| SRP007169 | SYMPK | 8189 | RNAseq | 0.5919 | 0.1315 | |
| SRP008496 | SYMPK | 8189 | RNAseq | 0.1795 | 0.5291 | |
| SRP064894 | SYMPK | 8189 | RNAseq | 0.9019 | 0.0000 | |
| SRP133303 | SYMPK | 8189 | RNAseq | 0.2804 | 0.0854 | |
| SRP159526 | SYMPK | 8189 | RNAseq | 0.7823 | 0.0082 | |
| SRP193095 | SYMPK | 8189 | RNAseq | 0.5523 | 0.0000 | |
| SRP219564 | SYMPK | 8189 | RNAseq | 0.5766 | 0.0202 | |
| TCGA | SYMPK | 8189 | RNAseq | 0.0346 | 0.4232 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SYMPK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SYMPK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SYMPK | 8189 | 4 | 5 | 21 | |
| GSE20123 | SYMPK | 8189 | 4 | 4 | 22 | |
| GSE43470 | SYMPK | 8189 | 3 | 11 | 29 | |
| GSE46452 | SYMPK | 8189 | 45 | 1 | 13 | |
| GSE47630 | SYMPK | 8189 | 8 | 7 | 25 | |
| GSE54993 | SYMPK | 8189 | 17 | 4 | 49 | |
| GSE54994 | SYMPK | 8189 | 5 | 13 | 35 | |
| GSE60625 | SYMPK | 8189 | 9 | 0 | 2 | |
| GSE74703 | SYMPK | 8189 | 3 | 7 | 26 | |
| GSE74704 | SYMPK | 8189 | 4 | 2 | 14 | |
| TCGA | SYMPK | 8189 | 16 | 15 | 65 |
Total number of gains: 118; Total number of losses: 69; Total Number of normals: 301.
Somatic mutations of SYMPK:
Generating mutation plots.
Highly correlated genes for SYMPK:
Showing top 20/197 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SYMPK | DDX59 | 0.786873 | 4 | 0 | 4 |
| SYMPK | ZFYVE9 | 0.770327 | 3 | 0 | 3 |
| SYMPK | NOMO3 | 0.757462 | 3 | 0 | 3 |
| SYMPK | AARS2 | 0.750606 | 3 | 0 | 3 |
| SYMPK | DNMT3A | 0.746402 | 4 | 0 | 4 |
| SYMPK | NIT2 | 0.74541 | 3 | 0 | 3 |
| SYMPK | ZNF669 | 0.73767 | 3 | 0 | 3 |
| SYMPK | GNAI2 | 0.736998 | 3 | 0 | 3 |
| SYMPK | ATF7IP | 0.734589 | 5 | 0 | 5 |
| SYMPK | TRMT61A | 0.728764 | 3 | 0 | 3 |
| SYMPK | AKAP17A | 0.72582 | 5 | 0 | 5 |
| SYMPK | TAF3 | 0.725551 | 3 | 0 | 3 |
| SYMPK | FKBP10 | 0.723878 | 3 | 0 | 3 |
| SYMPK | TMEM222 | 0.723239 | 3 | 0 | 3 |
| SYMPK | VASP | 0.720648 | 3 | 0 | 3 |
| SYMPK | KHNYN | 0.715611 | 3 | 0 | 3 |
| SYMPK | RBM6 | 0.7115 | 4 | 0 | 4 |
| SYMPK | PLSCR1 | 0.708981 | 3 | 0 | 3 |
| SYMPK | ZFYVE27 | 0.707112 | 3 | 0 | 3 |
| SYMPK | GTPBP1 | 0.706252 | 4 | 0 | 4 |
For details and further investigation, click here
