| Full name: docking protein 4 | Alias Symbol: FLJ10488 | ||
| Type: protein-coding gene | Cytoband: 16q21 | ||
| Entrez ID: 55715 | HGNC ID: HGNC:19868 | Ensembl Gene: ENSG00000125170 | OMIM ID: 608333 |
| Drug and gene relationship at DGIdb | |||
Expression of DOK4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DOK4 | 55715 | 209691_s_at | -0.1659 | 0.8306 | |
| GSE20347 | DOK4 | 55715 | 209691_s_at | -1.2090 | 0.0000 | |
| GSE23400 | DOK4 | 55715 | 209691_s_at | -0.6707 | 0.0000 | |
| GSE26886 | DOK4 | 55715 | 209691_s_at | -1.6660 | 0.0000 | |
| GSE29001 | DOK4 | 55715 | 209691_s_at | -1.3129 | 0.0014 | |
| GSE38129 | DOK4 | 55715 | 209691_s_at | -0.8823 | 0.0000 | |
| GSE45670 | DOK4 | 55715 | 209691_s_at | -0.3580 | 0.0482 | |
| GSE53622 | DOK4 | 55715 | 136678 | -0.9703 | 0.0000 | |
| GSE53624 | DOK4 | 55715 | 136678 | -1.1012 | 0.0000 | |
| GSE63941 | DOK4 | 55715 | 209691_s_at | -1.7140 | 0.0033 | |
| GSE77861 | DOK4 | 55715 | 209691_s_at | -0.5870 | 0.0451 | |
| GSE97050 | DOK4 | 55715 | A_24_P48069 | -0.3965 | 0.3193 | |
| SRP007169 | DOK4 | 55715 | RNAseq | -2.1672 | 0.0000 | |
| SRP008496 | DOK4 | 55715 | RNAseq | -1.8739 | 0.0000 | |
| SRP064894 | DOK4 | 55715 | RNAseq | -0.7731 | 0.0003 | |
| SRP133303 | DOK4 | 55715 | RNAseq | -0.8897 | 0.0001 | |
| SRP159526 | DOK4 | 55715 | RNAseq | -1.0410 | 0.0007 | |
| SRP193095 | DOK4 | 55715 | RNAseq | -1.4095 | 0.0000 | |
| SRP219564 | DOK4 | 55715 | RNAseq | -1.1468 | 0.0054 | |
| TCGA | DOK4 | 55715 | RNAseq | -0.3696 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by DOK4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DOK4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DOK4 | 55715 | 6 | 0 | 24 | |
| GSE20123 | DOK4 | 55715 | 6 | 1 | 23 | |
| GSE43470 | DOK4 | 55715 | 3 | 5 | 35 | |
| GSE46452 | DOK4 | 55715 | 38 | 1 | 20 | |
| GSE47630 | DOK4 | 55715 | 10 | 8 | 22 | |
| GSE54993 | DOK4 | 55715 | 2 | 4 | 64 | |
| GSE54994 | DOK4 | 55715 | 7 | 10 | 36 | |
| GSE60625 | DOK4 | 55715 | 4 | 0 | 7 | |
| GSE74703 | DOK4 | 55715 | 3 | 3 | 30 | |
| GSE74704 | DOK4 | 55715 | 5 | 0 | 15 | |
| TCGA | DOK4 | 55715 | 26 | 12 | 58 |
Total number of gains: 110; Total number of losses: 44; Total Number of normals: 334.
Somatic mutations of DOK4:
Generating mutation plots.
Highly correlated genes for DOK4:
Showing top 20/1453 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DOK4 | CCDC25 | 0.782474 | 3 | 0 | 3 |
| DOK4 | CA13 | 0.780654 | 3 | 0 | 3 |
| DOK4 | SNORA68 | 0.777175 | 3 | 0 | 3 |
| DOK4 | PDLIM2 | 0.774183 | 10 | 0 | 10 |
| DOK4 | S100A16 | 0.771948 | 6 | 0 | 6 |
| DOK4 | RAB5B | 0.770194 | 10 | 0 | 10 |
| DOK4 | CWH43 | 0.766902 | 10 | 0 | 10 |
| DOK4 | CES2 | 0.766182 | 8 | 0 | 8 |
| DOK4 | ACAA1 | 0.763589 | 10 | 0 | 9 |
| DOK4 | RAB11A | 0.762453 | 11 | 0 | 11 |
| DOK4 | GDPD3 | 0.761124 | 10 | 0 | 10 |
| DOK4 | RAB10 | 0.759638 | 6 | 0 | 6 |
| DOK4 | PDCD6IP | 0.758493 | 11 | 0 | 11 |
| DOK4 | MFSD5 | 0.756076 | 12 | 0 | 12 |
| DOK4 | ELMO2 | 0.752184 | 12 | 0 | 12 |
| DOK4 | ZNF70 | 0.750244 | 3 | 0 | 3 |
| DOK4 | DHRS1 | 0.749195 | 10 | 0 | 10 |
| DOK4 | TRMT1L | 0.748569 | 3 | 0 | 3 |
| DOK4 | ARHGEF10L | 0.746114 | 10 | 0 | 10 |
| DOK4 | TOM1 | 0.744135 | 11 | 0 | 9 |
For details and further investigation, click here
