| Full name: ATP citrate lyase | Alias Symbol: ATPCL|CLATP|ACL | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 47 | HGNC ID: HGNC:115 | Ensembl Gene: ENSG00000131473 | OMIM ID: 108728 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ACLY:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACLY | 47 | 201128_s_at | 0.8805 | 0.0439 | |
| GSE20347 | ACLY | 47 | 201128_s_at | 0.9599 | 0.0000 | |
| GSE23400 | ACLY | 47 | 201128_s_at | 0.9791 | 0.0000 | |
| GSE26886 | ACLY | 47 | 201128_s_at | 0.8046 | 0.0000 | |
| GSE29001 | ACLY | 47 | 201128_s_at | 0.7850 | 0.0001 | |
| GSE38129 | ACLY | 47 | 201128_s_at | 0.9799 | 0.0000 | |
| GSE45670 | ACLY | 47 | 201128_s_at | 0.7586 | 0.0004 | |
| GSE53622 | ACLY | 47 | 124112 | 0.9814 | 0.0000 | |
| GSE53624 | ACLY | 47 | 124112 | 1.0810 | 0.0000 | |
| GSE63941 | ACLY | 47 | 201128_s_at | -0.6403 | 0.1558 | |
| GSE77861 | ACLY | 47 | 201128_s_at | 1.0594 | 0.0009 | |
| GSE97050 | ACLY | 47 | A_33_P3415042 | 0.8909 | 0.0620 | |
| SRP007169 | ACLY | 47 | RNAseq | 2.1834 | 0.0000 | |
| SRP008496 | ACLY | 47 | RNAseq | 1.6069 | 0.0000 | |
| SRP064894 | ACLY | 47 | RNAseq | 0.9480 | 0.0000 | |
| SRP133303 | ACLY | 47 | RNAseq | 0.9081 | 0.0000 | |
| SRP159526 | ACLY | 47 | RNAseq | 0.9313 | 0.0034 | |
| SRP193095 | ACLY | 47 | RNAseq | 0.8287 | 0.0000 | |
| SRP219564 | ACLY | 47 | RNAseq | 0.6705 | 0.0258 | |
| TCGA | ACLY | 47 | RNAseq | 0.1294 | 0.0077 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by ACLY expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACLY:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACLY | 47 | 6 | 2 | 22 | |
| GSE20123 | ACLY | 47 | 6 | 2 | 22 | |
| GSE43470 | ACLY | 47 | 1 | 2 | 40 | |
| GSE46452 | ACLY | 47 | 34 | 0 | 25 | |
| GSE47630 | ACLY | 47 | 8 | 1 | 31 | |
| GSE54993 | ACLY | 47 | 3 | 4 | 63 | |
| GSE54994 | ACLY | 47 | 8 | 5 | 40 | |
| GSE60625 | ACLY | 47 | 4 | 0 | 7 | |
| GSE74703 | ACLY | 47 | 1 | 1 | 34 | |
| GSE74704 | ACLY | 47 | 4 | 1 | 15 | |
| TCGA | ACLY | 47 | 23 | 6 | 67 |
Total number of gains: 98; Total number of losses: 24; Total Number of normals: 366.
Somatic mutations of ACLY:
Generating mutation plots.
Highly correlated genes for ACLY:
Showing top 20/2133 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACLY | DNMT1 | 0.807611 | 11 | 0 | 11 |
| ACLY | GMPS | 0.794482 | 11 | 0 | 11 |
| ACLY | GNG10 | 0.790242 | 3 | 0 | 3 |
| ACLY | CMSS1 | 0.786125 | 6 | 0 | 6 |
| ACLY | PYCR2 | 0.782866 | 3 | 0 | 3 |
| ACLY | KIF14 | 0.775775 | 11 | 0 | 11 |
| ACLY | PLAU | 0.771701 | 11 | 0 | 11 |
| ACLY | DDX39A | 0.767394 | 10 | 0 | 10 |
| ACLY | MRPL47 | 0.764028 | 7 | 0 | 7 |
| ACLY | KNSTRN | 0.762372 | 5 | 0 | 5 |
| ACLY | MTHFD2 | 0.76227 | 11 | 0 | 11 |
| ACLY | ITPR3 | 0.762197 | 11 | 0 | 11 |
| ACLY | FADS1 | 0.761823 | 3 | 0 | 3 |
| ACLY | SLC35B2 | 0.761062 | 3 | 0 | 3 |
| ACLY | HMGB3 | 0.76088 | 11 | 0 | 11 |
| ACLY | MMP1 | 0.760832 | 11 | 0 | 11 |
| ACLY | PTRH2 | 0.759288 | 11 | 0 | 11 |
| ACLY | EME1 | 0.758351 | 5 | 0 | 5 |
| ACLY | KIF18B | 0.758309 | 9 | 0 | 9 |
| ACLY | AURKA | 0.75809 | 11 | 0 | 11 |
For details and further investigation, click here
