| Full name: proteasome 26S subunit, non-ATPase 3 | Alias Symbol: S3|P58|Rpn3 | ||
| Type: protein-coding gene | Cytoband: 17q21.1 | ||
| Entrez ID: 5709 | HGNC ID: HGNC:9560 | Ensembl Gene: ENSG00000108344 | OMIM ID: 617676 |
| Drug and gene relationship at DGIdb | |||
Expression of PSMD3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PSMD3 | 5709 | 201388_at | 0.6551 | 0.0494 | |
| GSE20347 | PSMD3 | 5709 | 201388_at | 0.7112 | 0.0037 | |
| GSE23400 | PSMD3 | 5709 | 201388_at | 0.5570 | 0.0000 | |
| GSE26886 | PSMD3 | 5709 | 201388_at | 1.4016 | 0.0000 | |
| GSE29001 | PSMD3 | 5709 | 201388_at | 0.2326 | 0.5691 | |
| GSE38129 | PSMD3 | 5709 | 201388_at | 0.8194 | 0.0000 | |
| GSE45670 | PSMD3 | 5709 | 201388_at | 0.8017 | 0.0018 | |
| GSE53622 | PSMD3 | 5709 | 56173 | 0.6504 | 0.0000 | |
| GSE53624 | PSMD3 | 5709 | 56173 | 0.7294 | 0.0000 | |
| GSE63941 | PSMD3 | 5709 | 201388_at | 0.7574 | 0.0154 | |
| GSE77861 | PSMD3 | 5709 | 201388_at | 1.1288 | 0.0005 | |
| GSE97050 | PSMD3 | 5709 | A_24_P289726 | 0.3989 | 0.1879 | |
| SRP007169 | PSMD3 | 5709 | RNAseq | 0.6568 | 0.1584 | |
| SRP008496 | PSMD3 | 5709 | RNAseq | 0.1607 | 0.5953 | |
| SRP064894 | PSMD3 | 5709 | RNAseq | 0.6322 | 0.0003 | |
| SRP133303 | PSMD3 | 5709 | RNAseq | 0.7048 | 0.0000 | |
| SRP159526 | PSMD3 | 5709 | RNAseq | 0.6241 | 0.0001 | |
| SRP193095 | PSMD3 | 5709 | RNAseq | 0.7321 | 0.0000 | |
| SRP219564 | PSMD3 | 5709 | RNAseq | 0.4558 | 0.1956 | |
| TCGA | PSMD3 | 5709 | RNAseq | 0.2760 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by PSMD3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PSMD3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PSMD3 | 5709 | 9 | 1 | 20 | |
| GSE20123 | PSMD3 | 5709 | 9 | 1 | 20 | |
| GSE43470 | PSMD3 | 5709 | 1 | 2 | 40 | |
| GSE46452 | PSMD3 | 5709 | 34 | 0 | 25 | |
| GSE47630 | PSMD3 | 5709 | 8 | 1 | 31 | |
| GSE54993 | PSMD3 | 5709 | 3 | 4 | 63 | |
| GSE54994 | PSMD3 | 5709 | 9 | 5 | 39 | |
| GSE60625 | PSMD3 | 5709 | 4 | 0 | 7 | |
| GSE74703 | PSMD3 | 5709 | 1 | 1 | 34 | |
| GSE74704 | PSMD3 | 5709 | 5 | 1 | 14 | |
| TCGA | PSMD3 | 5709 | 23 | 8 | 65 |
Total number of gains: 106; Total number of losses: 24; Total Number of normals: 358.
Somatic mutations of PSMD3:
Generating mutation plots.
Highly correlated genes for PSMD3:
Showing top 20/1812 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PSMD3 | PRELID1 | 0.848406 | 3 | 0 | 3 |
| PSMD3 | ITM2C | 0.815441 | 3 | 0 | 3 |
| PSMD3 | C15orf61 | 0.785317 | 3 | 0 | 3 |
| PSMD3 | TTC7B | 0.7819 | 3 | 0 | 3 |
| PSMD3 | C12orf57 | 0.776854 | 3 | 0 | 3 |
| PSMD3 | TCF12 | 0.770136 | 3 | 0 | 3 |
| PSMD3 | TMTC1 | 0.765938 | 3 | 0 | 3 |
| PSMD3 | DHRS13 | 0.758589 | 4 | 0 | 4 |
| PSMD3 | LIN52 | 0.755632 | 3 | 0 | 3 |
| PSMD3 | STAG1 | 0.749122 | 3 | 0 | 3 |
| PSMD3 | PSMD11 | 0.747678 | 10 | 0 | 9 |
| PSMD3 | AATF | 0.74574 | 12 | 0 | 11 |
| PSMD3 | EFTUD2 | 0.74533 | 8 | 0 | 8 |
| PSMD3 | WDR81 | 0.741166 | 4 | 0 | 4 |
| PSMD3 | FYN | 0.740981 | 3 | 0 | 3 |
| PSMD3 | ZNF707 | 0.739473 | 3 | 0 | 3 |
| PSMD3 | SNRPG | 0.732599 | 11 | 0 | 11 |
| PSMD3 | ACLY | 0.727795 | 10 | 0 | 10 |
| PSMD3 | DNMT1 | 0.727147 | 11 | 0 | 11 |
| PSMD3 | TERF2IP | 0.726895 | 3 | 0 | 3 |
For details and further investigation, click here
