| Full name: proteasome subunit beta 3 | Alias Symbol: HC10-II|MGC4147 | ||
| Type: protein-coding gene | Cytoband: 17q12 | ||
| Entrez ID: 5691 | HGNC ID: HGNC:9540 | Ensembl Gene: ENSG00000277791 | OMIM ID: 602176 |
| Drug and gene relationship at DGIdb | |||
Expression of PSMB3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PSMB3 | 5691 | 201400_at | 0.5898 | 0.0496 | |
| GSE20347 | PSMB3 | 5691 | 201400_at | 0.4396 | 0.0286 | |
| GSE23400 | PSMB3 | 5691 | 201400_at | 0.6532 | 0.0000 | |
| GSE26886 | PSMB3 | 5691 | 201400_at | 0.4320 | 0.1258 | |
| GSE29001 | PSMB3 | 5691 | 201400_at | 0.1548 | 0.7379 | |
| GSE38129 | PSMB3 | 5691 | 201400_at | 0.6629 | 0.0000 | |
| GSE45670 | PSMB3 | 5691 | 201400_at | 0.6494 | 0.0022 | |
| GSE53622 | PSMB3 | 5691 | 34381 | 0.9301 | 0.0000 | |
| GSE53624 | PSMB3 | 5691 | 34381 | 1.1903 | 0.0000 | |
| GSE63941 | PSMB3 | 5691 | 201400_at | 0.8023 | 0.0058 | |
| GSE77861 | PSMB3 | 5691 | 201400_at | 0.7465 | 0.0003 | |
| GSE97050 | PSMB3 | 5691 | A_33_P3234899 | 0.6799 | 0.1204 | |
| SRP007169 | PSMB3 | 5691 | RNAseq | 0.2786 | 0.3660 | |
| SRP008496 | PSMB3 | 5691 | RNAseq | 0.1758 | 0.3743 | |
| SRP064894 | PSMB3 | 5691 | RNAseq | 1.1857 | 0.0002 | |
| SRP133303 | PSMB3 | 5691 | RNAseq | 0.6908 | 0.0002 | |
| SRP159526 | PSMB3 | 5691 | RNAseq | 0.6292 | 0.0000 | |
| SRP193095 | PSMB3 | 5691 | RNAseq | 0.3269 | 0.0167 | |
| SRP219564 | PSMB3 | 5691 | RNAseq | 0.3986 | 0.3835 | |
| TCGA | PSMB3 | 5691 | RNAseq | 0.2882 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by PSMB3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PSMB3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PSMB3 | 5691 | 7 | 1 | 22 | |
| GSE20123 | PSMB3 | 5691 | 7 | 1 | 22 | |
| GSE43470 | PSMB3 | 5691 | 0 | 1 | 42 | |
| GSE46452 | PSMB3 | 5691 | 34 | 0 | 25 | |
| GSE47630 | PSMB3 | 5691 | 8 | 1 | 31 | |
| GSE54993 | PSMB3 | 5691 | 3 | 4 | 63 | |
| GSE54994 | PSMB3 | 5691 | 8 | 5 | 40 | |
| GSE60625 | PSMB3 | 5691 | 4 | 0 | 7 | |
| GSE74703 | PSMB3 | 5691 | 0 | 0 | 36 | |
| GSE74704 | PSMB3 | 5691 | 4 | 1 | 15 | |
| TCGA | PSMB3 | 5691 | 19 | 9 | 68 |
Total number of gains: 94; Total number of losses: 23; Total Number of normals: 371.
Somatic mutations of PSMB3:
Generating mutation plots.
Highly correlated genes for PSMB3:
Showing top 20/1748 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PSMB3 | SNAP47 | 0.765409 | 3 | 0 | 3 |
| PSMB3 | ZIC5 | 0.764803 | 3 | 0 | 3 |
| PSMB3 | PYCR2 | 0.760244 | 3 | 0 | 3 |
| PSMB3 | HAUS8 | 0.756041 | 6 | 0 | 6 |
| PSMB3 | AATF | 0.753762 | 13 | 0 | 12 |
| PSMB3 | NTMT1 | 0.753581 | 5 | 0 | 5 |
| PSMB3 | PSMB2 | 0.741252 | 12 | 0 | 11 |
| PSMB3 | KIF4A | 0.740347 | 9 | 0 | 9 |
| PSMB3 | CDCA2 | 0.737585 | 5 | 0 | 5 |
| PSMB3 | DKC1 | 0.732693 | 3 | 0 | 3 |
| PSMB3 | SLC19A1 | 0.731358 | 3 | 0 | 3 |
| PSMB3 | MMP1 | 0.7283 | 9 | 0 | 9 |
| PSMB3 | KIF14 | 0.72417 | 10 | 0 | 10 |
| PSMB3 | TTYH3 | 0.721186 | 7 | 0 | 6 |
| PSMB3 | PSMD3 | 0.720753 | 13 | 0 | 11 |
| PSMB3 | NDUFB9 | 0.719379 | 7 | 0 | 6 |
| PSMB3 | EME1 | 0.713288 | 5 | 0 | 5 |
| PSMB3 | CKS1B | 0.712902 | 12 | 0 | 10 |
| PSMB3 | TPX2 | 0.711891 | 11 | 0 | 10 |
| PSMB3 | TUBG1 | 0.710962 | 12 | 0 | 12 |
For details and further investigation, click here
