| Full name: ATP binding cassette subfamily C member 4 | Alias Symbol: MRP4|EST170205|MOAT-B|MOATB | ||
| Type: protein-coding gene | Cytoband: 13q32.1 | ||
| Entrez ID: 10257 | HGNC ID: HGNC:55 | Ensembl Gene: ENSG00000125257 | OMIM ID: 605250 |
| Drug and gene relationship at DGIdb | |||
Expression of ABCC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ABCC4 | 10257 | 203196_at | 0.8362 | 0.2167 | |
| GSE20347 | ABCC4 | 10257 | 203196_at | 0.7203 | 0.0004 | |
| GSE23400 | ABCC4 | 10257 | 203196_at | 0.2824 | 0.0001 | |
| GSE26886 | ABCC4 | 10257 | 203196_at | 1.0857 | 0.0245 | |
| GSE29001 | ABCC4 | 10257 | 203196_at | 0.0080 | 0.9877 | |
| GSE38129 | ABCC4 | 10257 | 203196_at | 0.8602 | 0.0000 | |
| GSE45670 | ABCC4 | 10257 | 203196_at | 0.6698 | 0.0251 | |
| GSE53622 | ABCC4 | 10257 | 14119 | 0.8158 | 0.0000 | |
| GSE53624 | ABCC4 | 10257 | 14119 | 1.0247 | 0.0000 | |
| GSE63941 | ABCC4 | 10257 | 203196_at | -2.3787 | 0.0106 | |
| GSE77861 | ABCC4 | 10257 | 203196_at | 0.3990 | 0.0189 | |
| GSE97050 | ABCC4 | 10257 | A_24_P16913 | 0.7233 | 0.0700 | |
| SRP007169 | ABCC4 | 10257 | RNAseq | 1.3071 | 0.0088 | |
| SRP008496 | ABCC4 | 10257 | RNAseq | 1.9434 | 0.0000 | |
| SRP064894 | ABCC4 | 10257 | RNAseq | 0.7515 | 0.0015 | |
| SRP133303 | ABCC4 | 10257 | RNAseq | 0.6440 | 0.0137 | |
| SRP159526 | ABCC4 | 10257 | RNAseq | 0.6927 | 0.0788 | |
| SRP193095 | ABCC4 | 10257 | RNAseq | 0.4744 | 0.0013 | |
| SRP219564 | ABCC4 | 10257 | RNAseq | 0.7482 | 0.0421 | |
| TCGA | ABCC4 | 10257 | RNAseq | 0.0420 | 0.6465 |
Upregulated datasets: 4; Downregulated datasets: 1.
Survival by ABCC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ABCC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ABCC4 | 10257 | 4 | 9 | 17 | |
| GSE20123 | ABCC4 | 10257 | 4 | 9 | 17 | |
| GSE43470 | ABCC4 | 10257 | 2 | 12 | 29 | |
| GSE46452 | ABCC4 | 10257 | 0 | 32 | 27 | |
| GSE47630 | ABCC4 | 10257 | 3 | 27 | 10 | |
| GSE54993 | ABCC4 | 10257 | 11 | 3 | 56 | |
| GSE54994 | ABCC4 | 10257 | 3 | 13 | 37 | |
| GSE60625 | ABCC4 | 10257 | 0 | 3 | 8 | |
| GSE74703 | ABCC4 | 10257 | 2 | 10 | 24 | |
| GSE74704 | ABCC4 | 10257 | 2 | 8 | 10 | |
| TCGA | ABCC4 | 10257 | 12 | 34 | 50 |
Total number of gains: 43; Total number of losses: 160; Total Number of normals: 285.
Somatic mutations of ABCC4:
Generating mutation plots.
Highly correlated genes for ABCC4:
Showing top 20/1360 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ABCC4 | ACTR3 | 0.77292 | 3 | 0 | 3 |
| ABCC4 | ETV6 | 0.768917 | 3 | 0 | 3 |
| ABCC4 | TMTC1 | 0.766589 | 4 | 0 | 4 |
| ABCC4 | ZNF260 | 0.756945 | 3 | 0 | 3 |
| ABCC4 | RPF2 | 0.75636 | 3 | 0 | 3 |
| ABCC4 | PI15 | 0.748943 | 4 | 0 | 4 |
| ABCC4 | DHRSX | 0.736045 | 4 | 0 | 4 |
| ABCC4 | RGS18 | 0.730922 | 3 | 0 | 3 |
| ABCC4 | KDSR | 0.729796 | 3 | 0 | 3 |
| ABCC4 | ALPK2 | 0.728826 | 3 | 0 | 3 |
| ABCC4 | REST | 0.726048 | 3 | 0 | 3 |
| ABCC4 | SMCR8 | 0.713037 | 4 | 0 | 4 |
| ABCC4 | TTC39C | 0.712693 | 4 | 0 | 4 |
| ABCC4 | UCK2 | 0.711456 | 3 | 0 | 3 |
| ABCC4 | TNFAIP1 | 0.70636 | 4 | 0 | 3 |
| ABCC4 | PGAP1 | 0.70302 | 4 | 0 | 3 |
| ABCC4 | ALG10 | 0.699628 | 5 | 0 | 4 |
| ABCC4 | TMEM150C | 0.695012 | 3 | 0 | 3 |
| ABCC4 | OSTC | 0.69413 | 5 | 0 | 5 |
| ABCC4 | HAS3 | 0.690809 | 4 | 0 | 3 |
For details and further investigation, click here
