| Full name: RE1 silencing transcription factor | Alias Symbol: NRSF|XBR | ||
| Type: protein-coding gene | Cytoband: 4q12 | ||
| Entrez ID: 5978 | HGNC ID: HGNC:9966 | Ensembl Gene: ENSG00000084093 | OMIM ID: 600571 |
| Drug and gene relationship at DGIdb | |||
REST involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05016 | Huntington's disease |
Expression of REST:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | REST | 5978 | 212920_at | 0.2671 | 0.3859 | |
| GSE20347 | REST | 5978 | 212920_at | -0.3553 | 0.0020 | |
| GSE23400 | REST | 5978 | 204535_s_at | 0.0135 | 0.7671 | |
| GSE26886 | REST | 5978 | 212920_at | -0.1539 | 0.4538 | |
| GSE29001 | REST | 5978 | 212920_at | -0.1949 | 0.5216 | |
| GSE38129 | REST | 5978 | 212920_at | -0.1237 | 0.3437 | |
| GSE45670 | REST | 5978 | 212920_at | 0.0115 | 0.9618 | |
| GSE53622 | REST | 5978 | 97387 | -0.0804 | 0.2814 | |
| GSE53624 | REST | 5978 | 97387 | 0.0584 | 0.4389 | |
| GSE63941 | REST | 5978 | 212920_at | -0.6227 | 0.1489 | |
| GSE77861 | REST | 5978 | 204535_s_at | -0.1168 | 0.3970 | |
| GSE97050 | REST | 5978 | A_23_P167081 | 0.1038 | 0.7082 | |
| SRP007169 | REST | 5978 | RNAseq | -0.5974 | 0.0704 | |
| SRP008496 | REST | 5978 | RNAseq | -0.2417 | 0.2543 | |
| SRP064894 | REST | 5978 | RNAseq | -0.1351 | 0.4974 | |
| SRP133303 | REST | 5978 | RNAseq | 0.2089 | 0.0640 | |
| SRP159526 | REST | 5978 | RNAseq | 0.0491 | 0.8060 | |
| SRP193095 | REST | 5978 | RNAseq | -0.1790 | 0.0316 | |
| SRP219564 | REST | 5978 | RNAseq | -0.2724 | 0.2589 | |
| TCGA | REST | 5978 | RNAseq | -0.0658 | 0.2273 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by REST expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of REST:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | REST | 5978 | 3 | 12 | 15 | |
| GSE20123 | REST | 5978 | 2 | 12 | 16 | |
| GSE43470 | REST | 5978 | 0 | 14 | 29 | |
| GSE46452 | REST | 5978 | 1 | 36 | 22 | |
| GSE47630 | REST | 5978 | 0 | 19 | 21 | |
| GSE54993 | REST | 5978 | 7 | 0 | 63 | |
| GSE54994 | REST | 5978 | 2 | 10 | 41 | |
| GSE60625 | REST | 5978 | 0 | 0 | 11 | |
| GSE74703 | REST | 5978 | 0 | 12 | 24 | |
| GSE74704 | REST | 5978 | 1 | 7 | 12 | |
| TCGA | REST | 5978 | 20 | 26 | 50 |
Total number of gains: 36; Total number of losses: 148; Total Number of normals: 304.
Somatic mutations of REST:
Generating mutation plots.
Highly correlated genes for REST:
Showing top 20/274 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| REST | NOA1 | 0.798174 | 3 | 0 | 3 |
| REST | PSMB7 | 0.780504 | 3 | 0 | 3 |
| REST | BZW1 | 0.775536 | 3 | 0 | 3 |
| REST | LACTB | 0.775097 | 3 | 0 | 3 |
| REST | AIMP1 | 0.772915 | 3 | 0 | 3 |
| REST | CASP3 | 0.772438 | 3 | 0 | 3 |
| REST | GLO1 | 0.771794 | 3 | 0 | 3 |
| REST | CDC123 | 0.766883 | 3 | 0 | 3 |
| REST | B3GALT6 | 0.766636 | 3 | 0 | 3 |
| REST | SRP9 | 0.759201 | 3 | 0 | 3 |
| REST | SUMO3 | 0.747512 | 3 | 0 | 3 |
| REST | TSN | 0.741881 | 3 | 0 | 3 |
| REST | C1QBP | 0.741803 | 3 | 0 | 3 |
| REST | MFN1 | 0.741113 | 3 | 0 | 3 |
| REST | ZNF394 | 0.738639 | 3 | 0 | 3 |
| REST | BLOC1S2 | 0.736121 | 3 | 0 | 3 |
| REST | CHMP2A | 0.735847 | 3 | 0 | 3 |
| REST | HMGN1 | 0.735451 | 3 | 0 | 3 |
| REST | PSMA5 | 0.7308 | 3 | 0 | 3 |
| REST | AQR | 0.728983 | 3 | 0 | 3 |
For details and further investigation, click here
