PXN

 

Full name: paxillin Alias Symbol: 
Type: protein-coding gene Cytoband: 12q24.23
Entrez ID: 5829 HGNC ID: HGNC:9718 Ensembl Gene: ENSG00000089159 OMIM ID: 602505
Drug and gene relationship at DGIdb
Screen Evidence:

 

PXN involved pathways:

KEGG pathway Description View
hsa04062Chemokine signaling pathway
hsa04370VEGF signaling pathway
hsa04510Focal adhesion
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa05100Bacterial invasion of epithelial cells
hsa05205Proteoglycans in cancer

 

Expression of PXN:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PXN 5829 201087_at 0.8204 0.0446
GSE20347 PXN 5829 201087_at 0.9864 0.0000
GSE23400 PXN 5829 201087_at 0.3740 0.0000
GSE26886 PXN 5829 201087_at 0.6043 0.0061
GSE29001 PXN 5829 201087_at 0.6014 0.0848
GSE38129 PXN 5829 201087_at 0.5796 0.0058
GSE45670 PXN 5829 201087_at 0.3592 0.1746
GSE53622 PXN 5829 32764 0.6765 0.0000
GSE53624 PXN 5829 32764 0.9033 0.0000
GSE63941 PXN 5829 201087_at 0.1352 0.7992
GSE77861 PXN 5829 201087_at 0.7746 0.0082
GSE97050 PXN 5829 A_33_P3380098 0.5019 0.1512
SRP007169 PXN 5829 RNAseq 0.8693 0.1054
SRP008496 PXN 5829 RNAseq 0.5637 0.0677
SRP064894 PXN 5829 RNAseq 0.5816 0.0009
SRP133303 PXN 5829 RNAseq 0.8948 0.0066
SRP159526 PXN 5829 RNAseq 0.3435 0.1600
SRP193095 PXN 5829 RNAseq 0.8889 0.0005
SRP219564 PXN 5829 RNAseq 0.2249 0.4306
TCGA PXN 5829 RNAseq 0.0216 0.7432

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PXN expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PXN:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PXN 5829 6 2 22
GSE20123 PXN 5829 6 2 22
GSE43470 PXN 5829 2 2 39
GSE46452 PXN 5829 9 1 49
GSE47630 PXN 5829 9 3 28
GSE54993 PXN 5829 0 5 65
GSE54994 PXN 5829 7 6 40
GSE60625 PXN 5829 0 0 11
GSE74703 PXN 5829 2 1 33
GSE74704 PXN 5829 3 2 15
TCGA PXN 5829 20 11 65

Total number of gains: 64; Total number of losses: 35; Total Number of normals: 389.  

 

Somatic mutations of PXN:

 

Generating mutation plots.

 

Highly correlated genes for PXN:

 

Showing top 20/1778 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PXNSCYL10.785228404
PXNMRPS50.765876303
PXNITGA30.76276312012
PXNNOM10.755764303
PXNCD2760.754119404
PXNCMTM40.752535303
PXNFMNL20.748705707
PXNZC3H180.747834303
PXNABI20.745383303
PXNATP11C0.744705303
PXNPTCD30.744594404
PXNLRRC8C0.742658303
PXNCCM20.735415807
PXNUSP210.734898303
PXNPSPC10.72996303
PXNU2SURP0.728829505
PXNSERPINH10.72752910010
PXNFLVCR10.72575403
PXNPKIG0.725397404
PXNCPT1A0.725397404

For details and further investigation, click here