SEMA4C

 

Full name: semaphorin 4C Alias Symbol: Semacl1|Semaf
Type: protein-coding gene Cytoband: 2q11.2
Entrez ID: 54910 HGNC ID: HGNC:10731 Ensembl Gene: ENSG00000168758 OMIM ID: 604462
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

SEMA4C involved pathways:

KEGG pathway Description View
hsa04360Axon guidance

 

Expression of SEMA4C:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SEMA4C 54910 46665_at 0.4988 0.0466
GSE20347 SEMA4C 54910 46665_at 0.5126 0.0075
GSE23400 SEMA4C 54910 46665_at 0.3717 0.0000
GSE26886 SEMA4C 54910 46665_at 1.3230 0.0000
GSE29001 SEMA4C 54910 46665_at 0.6385 0.1393
GSE38129 SEMA4C 54910 46665_at 0.3439 0.0764
GSE45670 SEMA4C 54910 46665_at 0.1178 0.6019
GSE53622 SEMA4C 54910 51799 0.1352 0.2101
GSE53624 SEMA4C 54910 51799 0.3543 0.0000
GSE63941 SEMA4C 54910 46665_at 0.7014 0.2505
GSE77861 SEMA4C 54910 46665_at 0.5125 0.0090
GSE97050 SEMA4C 54910 A_23_P114057 -0.2832 0.3271
SRP007169 SEMA4C 54910 RNAseq 0.2699 0.5524
SRP008496 SEMA4C 54910 RNAseq 0.5704 0.0435
SRP064894 SEMA4C 54910 RNAseq 0.3048 0.0336
SRP133303 SEMA4C 54910 RNAseq 0.2215 0.1680
SRP193095 SEMA4C 54910 RNAseq 0.5747 0.0003
SRP219564 SEMA4C 54910 RNAseq 0.1985 0.6683
TCGA SEMA4C 54910 RNAseq 0.0984 0.1850

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by SEMA4C expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SEMA4C:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SEMA4C 54910 6 2 22
GSE20123 SEMA4C 54910 6 2 22
GSE43470 SEMA4C 54910 2 3 38
GSE46452 SEMA4C 54910 2 3 54
GSE47630 SEMA4C 54910 7 0 33
GSE54993 SEMA4C 54910 0 6 64
GSE54994 SEMA4C 54910 11 0 42
GSE60625 SEMA4C 54910 0 3 8
GSE74703 SEMA4C 54910 2 2 32
GSE74704 SEMA4C 54910 4 1 15
TCGA SEMA4C 54910 35 3 58

Total number of gains: 75; Total number of losses: 25; Total Number of normals: 388.  

 

Somatic mutations of SEMA4C:

 

Generating mutation plots.

 

Highly correlated genes for SEMA4C:

 

Showing top 20/1411 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SEMA4CSTIP10.806531303
SEMA4CMRPL360.805358303
SEMA4CMED100.799909303
SEMA4CWDR660.784032303
SEMA4CHEATR60.780647505
SEMA4CMMRN20.778257303
SEMA4CACACA0.769426303
SEMA4CXXYLT10.7645303
SEMA4CEXOSC40.759004303
SEMA4CALKBH60.756974403
SEMA4CLINC003280.755692303
SEMA4CTP53I130.755629606
SEMA4CCRYBB20.749623303
SEMA4CCPNE80.744665303
SEMA4CTMED80.732516505
SEMA4CSSBP40.728441504
SEMA4CLTBR0.722801303
SEMA4CPLXNB30.717309303
SEMA4CRRP150.716204404
SEMA4CTNFRSF1A0.71298303

For details and further investigation, click here