MSH2

 

Full name: mutS homolog 2 Alias Symbol: HNPCC|HNPCC1
Type: protein-coding gene Cytoband: 2p21-p16.3
Entrez ID: 4436 HGNC ID: HGNC:7325 Ensembl Gene: ENSG00000095002 OMIM ID: 609309
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 9/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of MSH2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MSH2 4436 209421_at 0.7441 0.0391
GSE20347 MSH2 4436 209421_at 0.9802 0.0020
GSE23400 MSH2 4436 209421_at 0.6472 0.0000
GSE26886 MSH2 4436 209421_at 0.0690 0.8415
GSE29001 MSH2 4436 209421_at 0.6976 0.0715
GSE38129 MSH2 4436 209421_at 1.0351 0.0000
GSE45670 MSH2 4436 209421_at 0.3865 0.1222
GSE53622 MSH2 4436 34438 0.6491 0.0000
GSE53624 MSH2 4436 34438 0.6879 0.0000
GSE63941 MSH2 4436 209421_at 1.7818 0.0047
GSE77861 MSH2 4436 209421_at 0.4645 0.1516
GSE97050 MSH2 4436 A_33_P3287502 0.3243 0.2808
SRP007169 MSH2 4436 RNAseq 1.4358 0.0001
SRP008496 MSH2 4436 RNAseq 1.5266 0.0000
SRP064894 MSH2 4436 RNAseq 0.5330 0.0405
SRP133303 MSH2 4436 RNAseq 0.5475 0.0001
SRP159526 MSH2 4436 RNAseq 1.0736 0.0034
SRP193095 MSH2 4436 RNAseq 0.6253 0.0000
SRP219564 MSH2 4436 RNAseq 0.3234 0.3021
TCGA MSH2 4436 RNAseq 0.3724 0.0000

Upregulated datasets: 5; Downregulated datasets: 0.  

 

Survival by MSH2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MSH2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MSH2 4436 10 1 19
GSE20123 MSH2 4436 8 1 21
GSE43470 MSH2 4436 5 0 38
GSE46452 MSH2 4436 1 4 54
GSE47630 MSH2 4436 8 0 32
GSE54993 MSH2 4436 0 5 65
GSE54994 MSH2 4436 12 0 41
GSE60625 MSH2 4436 0 3 8
GSE74703 MSH2 4436 5 0 31
GSE74704 MSH2 4436 9 1 10
TCGA MSH2 4436 36 2 58

Total number of gains: 94; Total number of losses: 17; Total Number of normals: 377.  

 

Somatic mutations of MSH2:

 

Generating mutation plots.

 

Highly correlated genes for MSH2:

 

Showing top 20/1671 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MSH2MMS22L0.782091303
MSH2RAD180.781392303
MSH2BAP10.779338303
MSH2MSH60.77789813012
MSH2ACACA0.773864303
MSH2ACTR20.771286303
MSH2ANAPC10.766176303
MSH2MCM60.75738912011
MSH2NT5DC20.749899303
MSH2XPO10.74856813012
MSH2PPP1R80.746979505
MSH2MIF0.744926303
MSH2AURKAIP10.744907303
MSH2GMNN0.74072912011
MSH2RNF260.739235303
MSH2ORAI10.732996504
MSH2CCT40.73171312012
MSH2ARHGEF190.730009404
MSH2CENPA0.7293611011
MSH2MRPL380.728518303

For details and further investigation, click here