ACVR1

 

Full name: activin A receptor type 1 Alias Symbol: SKR1|ALK2|ACVR1A
Type: protein-coding gene Cytoband: 2q24.1
Entrez ID: 90 HGNC ID: HGNC:171 Ensembl Gene: ENSG00000115170 OMIM ID: 102576
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

ACVR1 involved pathways:

KEGG pathway Description View
hsa04350TGF-beta signaling pathway
hsa04550Signaling pathways regulating pluripotency of stem cells

 

Expression of ACVR1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ACVR1 90 203935_at 0.5230 0.3504
GSE20347 ACVR1 90 203935_at 1.0459 0.0002
GSE23400 ACVR1 90 203935_at 0.9193 0.0000
GSE26886 ACVR1 90 203935_at 1.9171 0.0000
GSE29001 ACVR1 90 203935_at 1.1172 0.0039
GSE38129 ACVR1 90 203935_at 1.0234 0.0000
GSE45670 ACVR1 90 203935_at 0.4727 0.0792
GSE53622 ACVR1 90 38837 0.9410 0.0000
GSE53624 ACVR1 90 38837 1.1088 0.0000
GSE63941 ACVR1 90 203935_at -2.6786 0.0003
GSE77861 ACVR1 90 203935_at 1.4843 0.0016
GSE97050 ACVR1 90 A_33_P3360665 0.6812 0.1186
SRP007169 ACVR1 90 RNAseq 1.8850 0.0000
SRP008496 ACVR1 90 RNAseq 2.0729 0.0000
SRP064894 ACVR1 90 RNAseq 1.1149 0.0000
SRP133303 ACVR1 90 RNAseq 1.3068 0.0000
SRP159526 ACVR1 90 RNAseq 0.8215 0.0083
SRP193095 ACVR1 90 RNAseq 1.0070 0.0000
SRP219564 ACVR1 90 RNAseq 0.7800 0.1152
TCGA ACVR1 90 RNAseq 0.2076 0.0004

Upregulated datasets: 11; Downregulated datasets: 1.  

 

Survival by ACVR1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ACVR1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ACVR1 90 4 1 25
GSE20123 ACVR1 90 4 1 25
GSE43470 ACVR1 90 4 1 38
GSE46452 ACVR1 90 1 4 54
GSE47630 ACVR1 90 5 3 32
GSE54993 ACVR1 90 0 4 66
GSE54994 ACVR1 90 11 2 40
GSE60625 ACVR1 90 0 3 8
GSE74703 ACVR1 90 3 1 32
GSE74704 ACVR1 90 3 0 17
TCGA ACVR1 90 22 10 64

Total number of gains: 57; Total number of losses: 30; Total Number of normals: 401.  

 

Somatic mutations of ACVR1:

 

Generating mutation plots.

 

Highly correlated genes for ACVR1:

 

Showing top 20/1740 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ACVR1RAB340.791394303
ACVR1LRRC8C0.786351303
ACVR1ITGAV0.77551813012
ACVR1SH3BP40.77464412012
ACVR1NF10.774352303
ACVR1WDR810.763847403
ACVR1CPT1A0.76384404
ACVR1PYCR20.763535303
ACVR1IRAK30.76182303
ACVR1GALNT180.757583606
ACVR1FADS10.755697303
ACVR1PTK20.7543861009
ACVR1FKBP70.753748606
ACVR1DPY19L10.75069212011
ACVR1GPX80.74703808
ACVR1RAI140.74396111010
ACVR1LHFPL20.74326912012
ACVR1VCAN0.74249812012
ACVR1GNG100.74021303
ACVR1NPHP30.739866303

For details and further investigation, click here