| Full name: SH3 domain binding protein 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q37.2 | ||
| Entrez ID: 23677 | HGNC ID: HGNC:10826 | Ensembl Gene: ENSG00000130147 | OMIM ID: 605611 |
| Drug and gene relationship at DGIdb | |||
Expression of SH3BP4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SH3BP4 | 23677 | 222258_s_at | 0.4340 | 0.2809 | |
| GSE20347 | SH3BP4 | 23677 | 222258_s_at | 1.0521 | 0.0000 | |
| GSE23400 | SH3BP4 | 23677 | 222258_s_at | 1.2401 | 0.0000 | |
| GSE26886 | SH3BP4 | 23677 | 222258_s_at | 2.7447 | 0.0000 | |
| GSE29001 | SH3BP4 | 23677 | 222258_s_at | 1.1228 | 0.0025 | |
| GSE38129 | SH3BP4 | 23677 | 222258_s_at | 1.0044 | 0.0000 | |
| GSE45670 | SH3BP4 | 23677 | 222258_s_at | 0.6137 | 0.0287 | |
| GSE53622 | SH3BP4 | 23677 | 19393 | 1.1845 | 0.0000 | |
| GSE53624 | SH3BP4 | 23677 | 19393 | 1.2772 | 0.0000 | |
| GSE63941 | SH3BP4 | 23677 | 222258_s_at | -1.0913 | 0.0521 | |
| GSE77861 | SH3BP4 | 23677 | 222258_s_at | 1.8766 | 0.0006 | |
| GSE97050 | SH3BP4 | 23677 | A_33_P3273369 | 0.5399 | 0.2310 | |
| SRP007169 | SH3BP4 | 23677 | RNAseq | 2.5966 | 0.0000 | |
| SRP008496 | SH3BP4 | 23677 | RNAseq | 2.5235 | 0.0000 | |
| SRP064894 | SH3BP4 | 23677 | RNAseq | 0.9006 | 0.0002 | |
| SRP133303 | SH3BP4 | 23677 | RNAseq | 1.1867 | 0.0000 | |
| SRP159526 | SH3BP4 | 23677 | RNAseq | 1.2737 | 0.0000 | |
| SRP193095 | SH3BP4 | 23677 | RNAseq | 1.1195 | 0.0000 | |
| SRP219564 | SH3BP4 | 23677 | RNAseq | 0.7855 | 0.0686 | |
| TCGA | SH3BP4 | 23677 | RNAseq | -0.0859 | 0.1838 |
Upregulated datasets: 13; Downregulated datasets: 0.
Survival by SH3BP4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SH3BP4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SH3BP4 | 23677 | 1 | 11 | 18 | |
| GSE20123 | SH3BP4 | 23677 | 1 | 11 | 18 | |
| GSE43470 | SH3BP4 | 23677 | 1 | 9 | 33 | |
| GSE46452 | SH3BP4 | 23677 | 0 | 5 | 54 | |
| GSE47630 | SH3BP4 | 23677 | 4 | 5 | 31 | |
| GSE54993 | SH3BP4 | 23677 | 3 | 2 | 65 | |
| GSE54994 | SH3BP4 | 23677 | 7 | 10 | 36 | |
| GSE60625 | SH3BP4 | 23677 | 0 | 3 | 8 | |
| GSE74703 | SH3BP4 | 23677 | 1 | 7 | 28 | |
| GSE74704 | SH3BP4 | 23677 | 1 | 5 | 14 | |
| TCGA | SH3BP4 | 23677 | 11 | 28 | 57 |
Total number of gains: 30; Total number of losses: 96; Total Number of normals: 362.
Somatic mutations of SH3BP4:
Generating mutation plots.
Highly correlated genes for SH3BP4:
Showing top 20/1280 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SH3BP4 | CD276 | 0.784264 | 5 | 0 | 5 |
| SH3BP4 | ACVR1 | 0.774644 | 12 | 0 | 12 |
| SH3BP4 | FNDC3B | 0.761384 | 10 | 0 | 10 |
| SH3BP4 | FMNL2 | 0.757092 | 7 | 0 | 7 |
| SH3BP4 | CBX3 | 0.749125 | 11 | 0 | 11 |
| SH3BP4 | FBRSL1 | 0.747088 | 3 | 0 | 3 |
| SH3BP4 | VOPP1 | 0.737319 | 10 | 0 | 10 |
| SH3BP4 | WDR54 | 0.736047 | 7 | 0 | 6 |
| SH3BP4 | TMEM184B | 0.731851 | 9 | 0 | 9 |
| SH3BP4 | PTK2 | 0.726936 | 9 | 0 | 9 |
| SH3BP4 | PPT1 | 0.724612 | 11 | 0 | 10 |
| SH3BP4 | DPY19L1 | 0.723927 | 11 | 0 | 11 |
| SH3BP4 | BID | 0.721927 | 12 | 0 | 11 |
| SH3BP4 | LRRC8D | 0.72136 | 11 | 0 | 10 |
| SH3BP4 | LRP12 | 0.716831 | 10 | 0 | 10 |
| SH3BP4 | LPCAT1 | 0.715546 | 10 | 0 | 9 |
| SH3BP4 | GALNT18 | 0.713902 | 6 | 0 | 6 |
| SH3BP4 | E2F6 | 0.712125 | 10 | 0 | 10 |
| SH3BP4 | MFAP2 | 0.70919 | 11 | 0 | 11 |
| SH3BP4 | COL4A1 | 0.708926 | 11 | 0 | 9 |
For details and further investigation, click here
