| Full name: solute carrier family 7 member 5 | Alias Symbol: LAT1|E16|D16S469E|MPE16|CD98 | ||
| Type: protein-coding gene | Cytoband: 16q24.2 | ||
| Entrez ID: 8140 | HGNC ID: HGNC:11063 | Ensembl Gene: ENSG00000103257 | OMIM ID: 600182 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SLC7A5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC7A5 | 8140 | 201195_s_at | 1.5121 | 0.0361 | |
| GSE20347 | SLC7A5 | 8140 | 201195_s_at | 0.5490 | 0.1054 | |
| GSE23400 | SLC7A5 | 8140 | 201195_s_at | 0.9032 | 0.0000 | |
| GSE26886 | SLC7A5 | 8140 | 201195_s_at | 0.1619 | 0.5712 | |
| GSE29001 | SLC7A5 | 8140 | 201195_s_at | 0.3700 | 0.5198 | |
| GSE38129 | SLC7A5 | 8140 | 201195_s_at | 1.1346 | 0.0010 | |
| GSE45670 | SLC7A5 | 8140 | 201195_s_at | 1.0630 | 0.0001 | |
| GSE53622 | SLC7A5 | 8140 | 28721 | 1.2775 | 0.0000 | |
| GSE53624 | SLC7A5 | 8140 | 28721 | 1.0971 | 0.0000 | |
| GSE63941 | SLC7A5 | 8140 | 201195_s_at | 3.5900 | 0.0002 | |
| GSE77861 | SLC7A5 | 8140 | 201195_s_at | 1.0174 | 0.0086 | |
| GSE97050 | SLC7A5 | 8140 | A_24_P335620 | 1.2210 | 0.1819 | |
| SRP007169 | SLC7A5 | 8140 | RNAseq | 0.7833 | 0.1150 | |
| SRP008496 | SLC7A5 | 8140 | RNAseq | 0.4978 | 0.1879 | |
| SRP064894 | SLC7A5 | 8140 | RNAseq | 0.5142 | 0.1680 | |
| SRP133303 | SLC7A5 | 8140 | RNAseq | 1.7520 | 0.0000 | |
| SRP159526 | SLC7A5 | 8140 | RNAseq | 0.8781 | 0.0862 | |
| SRP193095 | SLC7A5 | 8140 | RNAseq | 1.3003 | 0.0000 | |
| SRP219564 | SLC7A5 | 8140 | RNAseq | 1.5412 | 0.0879 | |
| TCGA | SLC7A5 | 8140 | RNAseq | 0.4004 | 0.0000 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by SLC7A5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC7A5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC7A5 | 8140 | 4 | 3 | 23 | |
| GSE20123 | SLC7A5 | 8140 | 4 | 3 | 23 | |
| GSE43470 | SLC7A5 | 8140 | 1 | 13 | 29 | |
| GSE46452 | SLC7A5 | 8140 | 38 | 1 | 20 | |
| GSE47630 | SLC7A5 | 8140 | 11 | 9 | 20 | |
| GSE54993 | SLC7A5 | 8140 | 3 | 4 | 63 | |
| GSE54994 | SLC7A5 | 8140 | 9 | 11 | 33 | |
| GSE60625 | SLC7A5 | 8140 | 4 | 0 | 7 | |
| GSE74703 | SLC7A5 | 8140 | 1 | 9 | 26 | |
| GSE74704 | SLC7A5 | 8140 | 3 | 2 | 15 | |
| TCGA | SLC7A5 | 8140 | 28 | 15 | 53 |
Total number of gains: 106; Total number of losses: 70; Total Number of normals: 312.
Somatic mutations of SLC7A5:
Generating mutation plots.
Highly correlated genes for SLC7A5:
Showing top 20/1302 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC7A5 | S100A11 | 0.76319 | 3 | 0 | 3 |
| SLC7A5 | EME1 | 0.76055 | 5 | 0 | 5 |
| SLC7A5 | UHRF1 | 0.752598 | 6 | 0 | 6 |
| SLC7A5 | CD276 | 0.74025 | 4 | 0 | 4 |
| SLC7A5 | RCC2 | 0.73936 | 6 | 0 | 6 |
| SLC7A5 | YWHAG | 0.736858 | 4 | 0 | 4 |
| SLC7A5 | SLC2A1 | 0.723332 | 9 | 0 | 9 |
| SLC7A5 | TTYH3 | 0.720757 | 6 | 0 | 6 |
| SLC7A5 | FBXO45 | 0.713645 | 3 | 0 | 3 |
| SLC7A5 | SH2D3A | 0.711772 | 3 | 0 | 3 |
| SLC7A5 | AURKB | 0.707148 | 10 | 0 | 9 |
| SLC7A5 | TUBA1B | 0.70667 | 4 | 0 | 3 |
| SLC7A5 | UBE2T | 0.705619 | 7 | 0 | 7 |
| SLC7A5 | CDCA5 | 0.705037 | 6 | 0 | 6 |
| SLC7A5 | SLC3A2 | 0.7041 | 13 | 0 | 10 |
| SLC7A5 | PTK7 | 0.703513 | 9 | 0 | 9 |
| SLC7A5 | CDC45 | 0.701657 | 10 | 0 | 10 |
| SLC7A5 | TRIP13 | 0.701443 | 10 | 0 | 9 |
| SLC7A5 | FOXN2 | 0.701238 | 5 | 0 | 5 |
| SLC7A5 | FANCD2 | 0.70042 | 5 | 0 | 5 |
For details and further investigation, click here
